Scientists Synthesize a New Molecule with the Ability to Kill a...
Scientists have developed ERX-41, a potent therapeutic drug with a well-defined molecular target (Lysosomal Acid Lipase, LAL) and mechanism of action (disruption of protein...
Transcriptome-Wide Association Studies Integrated with 3D Genomic and Epigenomic Data used...
Scientists from Pennsylvania State University integrated 3D genomic and epigenomic data with transcriptome-wide association studies data to improve gene expression predictions.
The researchers propose an integrative method...
Scientists Use CRISPR Technology and Perturb-seq to Map Every Human Gene...
Scientists from Whitehead Institute and collaborators used Perturb-seq, a single-cell sequencing technology, to link every expressed gene in the human genome to its function...
Scientists Develop a Novel Probabilistic Generative Model ‘RaptGen’ for Aptamer Generation
Scientists from the Graduate School of Advanced Science and Engineering at Waseda University, Japan, developed RaptGen, a variational autoencoder for in silico aptamer generation....
Scientists Develop a New Computer Vision Model with Improved Proficiency to...
Hospital for Special Surgery (HSS) researchers in New York City have developed a computer vision tool that effectively identifies rheumatoid arthritis (RA) from osteoarthritis...
Scientists Discover Superbug Develops Drug-Resistance to ‘last Resort’ Antibiotic Fast
New research from University of Oxford revealed that superbug Pseudomonas develops resistance to a common 'last-resort' antibiotic much faster than expected.
Recent research published in Cell Reports...
ColabFold: A Freely Accessible Protein Folding Tool for Accelerated Prediction of...
Scientists have developed ColabFold, an open-source software to accelerate the prediction of protein structures as well as complexes by integrating fast homology search of...
Scientists Discover New Mass Spectrometry-Based Proteomics Method For Early Detection of...
Through mass spectrometry-based proteomics, a German-Danish research team led by Matthias Mann has developed a new screening tool to identify alcohol-related liver disorders at...
Scientists Develop a Novel Approach for Early Disease Diagnosis Using DNA...
Scientists at Tokyo Tech have produced computational DNA droplets that can recognize specific patterns in tumor biomarker microRNA sequences by merging the technologies of...
A New Computer Simulation Coupled with Machine Learning Cracked the Mechanism...
A team led by the University of Maryland utilizes machine learning to explain why a "wonder drug" may not work in all patients.
Understanding how...
An Automated AI-Based Software ‘TrackMate v7’ for Tracking Things in Bioimages
Scientists from Akademi University, Turku, Finland, and Pasteur Institute, Paris, France have developed a new software TrackMate v7 that may allow tracking things in...
Scientists Discover How Protein Production is Regulated to Keep the Cells...
Scientists from Cold Spring Harbor Laboratory (CSHL) have discovered a key process which shows how protein production is regulated to keep the cells healthy....
PGDx Elio Tissue Complete – An Automated and FDA-Approved Clinical Genomics...
PGDx Elio tissue complete, which the FDA has approved for the analysis of 505 cancer-related genes, will enable the development of more effective precision...
Scientists Identify New Mechanism in Small Peptide that Shows Huge Potential...
Scientists used neutrons to learn more about how aurein 1.2, an antimicrobial peptide (AMP) that attacks bacteria's membranes, kills antibiotic-resistant bacteria. The research will...
Scientists Employ RNA Velocity and Deep Learning to Study Gene Regulation...
Scientists have developed DeepCycle, a deep learning approach combined with RNA velocity to reveal cell cycle gene regulation. This methodology is particularly appropriate to...
Scientists Develop Hybrid Molecules by Drug Repurposing in an Effort to...
Controlling the spread of the highly contagious disease and protecting human health requires developing new medications that stay effective against growing COVID-19 variations.
After spending...
Researchers Identify Blood Biomarker that can Predict Onset of Crohn’s Disease...
A team led by the University of Toronto researcher discovered that a blood antibody can predict severe Crohn's disease up to seven years before...
Scientists Develop a Mathematical Model to Predict the Efficiency of Phage...
Scientists from Inserm, Université Sorbonne Paris Nord, and Université Paris-Cité at the IAME Laboratory, with their collaborators at Institut Pasteur and the Paris Public...
The Future of Medicine is Here: Top Tech Transforming Drug Discovery
The advent of technological advances such as artificial intelligence (AI), machine learning (ML), automation, robotics, etc., has accelerated the pace of drug discovery as...
First Draft of Monkeypox Virus Genome Sequenced from Current Outbreak Patient
In a quest to understand why the monkeypox virus, which is a less lethal relative of smallpox, has infected so many people around the...
Scientists Develop a Machine Learning Algorithm that uses Electronic Health Records...
Scientists from Koa Health and Birmingham and Solihull Mental Health NHS Foundation Trust developed a machine learning model that uses electronic health records to...
Resistance Genes Identified can Predict Response to Arthritis Treatment and Lays...
Researchers from the Queen Mary University of London have shown that molecular profiling of diseased joint tissue can significantly impact whether specific medication treatments...
‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up...
The algorithm is the first full-fledged machine learning-based short read alignment algorithm to speed up DNA sequencing, that efficiently uses learned indices to solve...
Researchers Introduce a Smartphone-Powered Microchip for Medical Diagnostic Testing at Home
Researchers at the University of Minnesota developed a new microfluidic chip that can identify viruses, pathogens, bacteria, and other biomarkers in liquid samples.
A...
Scientists Develop a Machine Learning-Based Framework to Identify Shared and Disease-Specific...
Scientists from the University of Minnesota, Minneapolis, USA, with their collaborators, developed a machine learning framework for a multi-omic integration to identify the shared...
What is Bioinformatics?
Today's sequencing technologies are growing more advanced and producing larger and larger volumes of data in the range of exa- and zettabytes. Advanced algorithms...
‘CancerVar’ – A New Machine Learning Empowered Tool to Interpret Somatic...
CancerVar leverages machine learning frameworks to evaluate the potential relevance of somatic cancer mutations in terms of cancer diagnosis, prognosis, and targetability, in addition...
Enzyme Engineered by Structure-Based Machine Learning Degrades Plastic Waste in Hours...
A team of scientists and engineers at the University of Texas at Austin created an enzyme that could break down environmentally damaging polymers in...
Researchers Puzzled by the Structure of Key Protein Implicated in Cell...
Researchers from the Max Planck Institute reveal the first 3D image of the CCAN protein complex and highlight basic questions about the development of...
‘DeepRank’ – A Deep Learning Framework for Data Mining Protein-Protein Interfaces...
Scientists formulate a deep learning framework, DeepRank, for the data mining of 3D protein-protein interfaces. They demonstrated the efficiency and readiness of DeepRank on...
A Novel Parallel Graph Neural Networks Based Method for Decoding Protein-Ligand...
A deep learning-based method for predicting the biophysical and biochemical features of protein-ligand complexes developed by researchers could help discover new drug candidates.
Scientists formulate...
SARS-CoV-2 Delta Variant’s Unique Binding Leads to High Transmissibility
The National Institutes of Health's discovery could lead to new approaches to tackle future SARS-CoV-2 variants.
According to a study by experts at the National...
Impact of Antibiotics on the Evolution of Gut Microbiome and Antimicrobial...
Following a single antibiotic course, the researchers discover how gut commensals acquire antimicrobial resistance genes (ARGs). According to the researchers, a single round of...
Scientists Revealed the Human Genetic Epidemiology of the COVID-19 Disease
Scientists from the University of Helsinki, Broad Institute, and Harvard Medical School have revealed the human genetic epidemiology of the COVID-19 disease caused by...
Top 10 Applications of Artificial Intelligence in Healthcare
Top 10 Applications of Artificial Intelligence in Healthcare in 2022 and Beyond
The healthcare industry has always been one of the leaders in using technology...
A Smartphone App for Screening Neurological Disease at Home
The RGB selfie camera and the front-facing near-infrared camera equipped for facial recognition can be used to capture an image of the eye. The...
Deep Neural Network Based 3D Reconstruction of Cellular Images to Track...
Microscopic imagers may be used in oncology to track and observe cell motions and dynamics, indicating tissues' real-time response to therapy.
Scientists from the Department...
Artificial Intelligence Based ‘Waste-to-Valuable’ Algorithm for Repurposing Chemical Wastes into Useful...
The widespread use of computational waste-to-value algorithms can speed up the productive reuse of chemicals that would otherwise incur storage or disposal expenses or...
‘SINATRA Pro’ a Computational Pipeline for the Discovery of Biophysical Signatures...
A group of scientists jointly proposed SINATRA Pro, a computational system for the extraction of key structural features between two sets of proteins. SINATRA...
Scientists Engineered a New Tool to Precisely Switch Gene Expression ‘On’...
Scientists have developed a new approach for harnessing electrical signals to turn genes on and off.
A team led by Imperial College London experts has...
A Systems Genomics Approach to Identify Hidden Genetic Connections for Precision...
A new precision medicine tool 'iSNP' uncovers hidden genetic links that could enhance IBD and other difficult illnesses treatment.
A group of scientists and clinicians...
Repurposing FDA Approved Asthma Drug to Block Crucial SARS-CoV-2 Protein
In a new study by scientists from the Indian Institute of Science (IISc), repurposing a drug used to treat asthma and allergies has been...
Benefits and Challenges of ‘One-Size-Fits-All’ Anti-Tuberculosis Treatment Strategies
An expert scientist affiliated with the Center for Discovery and Innovation and a colleague from Harvard T.H. Chan School of Public Health discussed the...
Scientists from Scripps Research Developed a New Technique ‘CATCH’ to Pinpoint...
The new approach, developed by Scripps Research experts, has the potential to speed up the development of numerous novel drugs.
Scripps Research scientists have developed...
Scientists Discover a Sensitive Blood Test to Determine if a Pre-Cancerous...
A test developed by OHSU researchers could help doctors treat cancer earlier when it's more likely to be cured.
Scientists discover plasma cell-free RNA profiling,...
Scientists Develop a Machine Learning Model to Predict the Evolution of...
Machine learning algorithms can provide precise forecasting of virus propagation during pandemics. This method eliminates human bias and assumptions, allowing for a more accurate...
FDA-Approved Drugs Repurposing for Treating Alzheimer’s Disease using Hierarchical Cluster Analysis...
Scientists from Brown University identified the novel usage of FDA-approved drugs by cluster analysis of behavioral profiles for the treatment of neurodegenerative disorders by...
Artificial Intelligence Enables Physicians to Better Evaluate the Effectiveness of Bladder Cancer...
Consultation with a machine learning tool helped providers determine more accurately whether patients had a complete response to chemotherapy.
Scientists from the University of Michigan...
‘BioCRNpyler’ – A Python Package to Build, Manage and Explore Intricate...
Scientists from the California Institute of Technology, United States, have developed a python package, 'BioCRNpyler', to build, manage, and explore intricate biochemical models. BioCRNpyler...
Scientists Identify New Factors that Can Predict Breast Cancer Recurrence
Scientists at Georgetown Lombardi Comprehensive Cancer Center have uncovered genetics and other characteristics that can predict if a woman is at risk of breast...
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45 Days Hands-on Skill Development Summer Training/Internship on “From Base Pairs to Big Data:...
Are you ready to transform your understanding of bioinformatics and gain hands-on experience with cutting-edge tools and technologies? The Centre of Bioinformatics Research & Technology...
Vision Transformers: A New Era in Protein-Ligand Affinity Prediction
Predicting how tightly a drug molecule (ligand) binds to its protein target is a cornerstone of modern drug discovery. Yet, this task remains a...
Building Better Models: How AI and Experimentation Shape GPCR Research in AlphaFold Era
The GPCR Dock competitions are a set of community-wide evaluations of ligand docking and computational structural modeling for G protein-coupled receptors, a key class...
Fast, Accurate, and Flexible: How FLOWR is Transforming Molecular Design
In a recent breakthrough in AI-driven drug discovery, researchers from Pfizer, AstraZeneca, and Chalmers University unveiled a new generative framework called FLOWR, designed to...
Designer Miniproteins: New Frontier in GPCR-Targeted Drug Development
G protein-coupled receptors (GPCRs) are essential membrane proteins with dynamic conformations that are also major targets for drug development and discovery. However, designing protein...