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Single-Cell Map of Heart Failure Provides Insights into Novel Potential Therapeutic Targets and Biomarkers

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Heart Failure
Researchers have discovered molecular fingerprints that lead to biological causes of disease by analyzing individual cardiac cells from heart failure patients. Heart failure is an increasingly important public health issue because it comprises a diverse range of clinical characteristics that are all related to reduced heart contractile function. By performing single-nucleus RNA sequencing on nearly 600,000 nuclei in left ventricle samples...

TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition

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single-cell RNA sequencing, TAS-Seq, RNA Sequencing
The emergence of single-cell RNA sequencing (scRNA-seq) has now made it possible to analyze the internal workings of hundreds of cells at once, revolutionizing biology and medicine. However, the limitations of scRNA-seq methods include the potential for inaccurate cell composition analysis and the ineffectiveness of complementary DNA (cDNA) amplification, which is the process by which a double-stranded DNA that...

PICASSO Technique Helps Scientists Visualize Biological Molecules into Technicolor​

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picasso technique
Scientists from the Korea Advanced Institute of Science and Technology propose the PICASSO technique, which enables more than 15-color imaging of spatially overlapping proteins in a single imaging round without using any reference emission spectra. For a wide spectrum of researchers, the PICASSO technique offers a multiplexed imaging tool with great accessibility and accuracy. According to the research published in...

High-Resolution Cryo-EM Structure of Type IV Secretion System Offers New Hope for Fighting Antibiotic Resistance

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Antibiotic Resistance
A group of researchers from UCL and Birkbeck has discovered a novel strategy to help limit the spread of antibiotic resistance, which has the potential to have a huge worldwide impact on millions of people's lives. The groundbreaking study, which was published in Nature, revealed for the first time the structure of the transport mechanism that allows bacteria to exchange...

Applying 3D Computational Simulation to Reveal the Secrets of the Genome Structure in the Human Cell Nucleus

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genome structure
A research team from Nagoya University in Japan has created a 3-Dimensional computational simulation of the formation of the genome structure in the human cell nucleus. The model is expected to help in understanding cellular regulatory mechanisms and diseases like cancer that modify DNA. Because it influences DNA reading and replication, the three-dimensional shape of the genome is crucial in...

Scientists Integrate Genome Mining with PAN Genome Analysis to Discover the Potential of Bacterial Compounds and Genes Linked to Colon Cancer-Causing Toxin

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Colon Cancer
Scientists from the Technical University of Denmark (DTU) and the University of California San Diego present a systems biology workflow that integrates genome mining with a detailed pangenome analysis for detecting genes associated with a particular biosynthetic gene clusters (BGCs). The study will help find novel secondary metabolites, comprehend their physiological functions better, and find and examine gene sets...

Scientists Unravel How DNA Double Helix Structure is Opened to Allow DNA Replication

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double helix structure of DNA
Scientists at the Francis Crick Institute have uncovered how the DNA double helix structure is opened to allow DNA replication. The research could pave the way for additional investigations to understand this mechanism better, particularly how it can go wrong in conditions like cancer. Scientists have struggled to comprehend how the two strands of DNA are opened to access the...

Scientists Discover a New Mechanism for Endoplasmic Reticulum Sorting of LRR Receptor Kinases in Arabidopsis

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Endoplasmic Reticulum, Receptor Kinase
Scientists from the Chinese Academy of Sciences' Institute of Genetics and Developmental Biology (IGDB) have discovered a new mechanism that protects the endoplasmic reticulum (ER) sorting of Leucine-Rich Repeat Receptor Kinases (LRR-RKs) in Arabidopsis cells. In eukaryotic cells, protein sorting in the secretory pathway is critical for cellular compartmentalization and homeostasis. The endoplasmic reticulum is the secretory cargo protein's biosynthetic...

Scientists Develop Structural 3D Maps of Key Proteins that Go Wrong in Brain Disorders Revealing New Treatment Routes

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brain disorders
Cold Spring Harbor Laboratory (CSHL) scientist Professor Hiro Furukawa adopts an architectural approach to brain research. He makes structural 3D maps of key proteins that go wrong in brain disorders.  Furukawa has focused his research on the NMDA (N-methyl-D-aspartate) receptor, a protein involved in learning and memory. The N-methyl-D-aspartate receptors (NMDARs) are primarily found in the central nervous system, but...

Scientists Used a Netflix-Style Algorithm to Create Blueprint of Cancer Genomes

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Cancer Genomes
The algorithms that track users' Netflix viewing habits could soon be used to track cancer development in order to direct doctors in managing cancer. An international team of researchers led by Dr. Nischalan Pillay (UCL Cancer Institute) and Dr. Ludmil Alexandrov (University of California, San Diego) used AI to identify 21 frequent faults in the structure, order, and quantity of...

Must Read

Heart Failure

Single-Cell Map of Heart Failure Provides Insights into Novel Potential Therapeutic Targets and Biomarkers

0
Researchers have discovered molecular fingerprints that lead to biological causes of disease by analyzing individual cardiac cells from heart failure patients. Heart failure is an...
single-cell RNA sequencing, TAS-Seq, RNA Sequencing

TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition

0
The emergence of single-cell RNA sequencing (scRNA-seq) has now made it possible to analyze the internal workings of hundreds of cells at once, revolutionizing...
picasso technique

PICASSO Technique Helps Scientists Visualize Biological Molecules into Technicolor​

0
Scientists from the Korea Advanced Institute of Science and Technology propose the PICASSO technique, which enables more than 15-color imaging of spatially overlapping proteins...
Antibiotic Resistance

High-Resolution Cryo-EM Structure of Type IV Secretion System Offers New Hope for Fighting Antibiotic...

0
A group of researchers from UCL and Birkbeck has discovered a novel strategy to help limit the spread of antibiotic resistance, which has the...
genome structure

Applying 3D Computational Simulation to Reveal the Secrets of the Genome Structure in the...

0
A research team from Nagoya University in Japan has created a 3-Dimensional computational simulation of the formation of the genome structure in the human...