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A New Sequencing Technique Developed for Low-Biomass, Degraded, or Contaminated Microbiome Samples

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Microbiome
A low-cost metagenome sequencing technology has been developed by scientists from the Chinese Academy of Sciences' Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT). It allows high-resolution disclosure of a microbiome's whole 'landscape' of species, even from low-biomass, damaged, or polluted samples. The 'microbiome' is referred to a community of microorganisms (bacteria, fungi, protists, and viruses) that live in and...

Safely Inserting Therapeutic Genes into the Human DNA

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landing-therapeutic-genes
Researchers from Harvard's Wyss Institute, Harvard Medical School, and the ETH Zurich have predicted and validated genetic safe harbors for therapeutic genes, making gene and cell treatments safer, more efficient, more predictable. According to the researchers, “genomic safe harbors (GSHs)” could enhance the efficacy, persistence, and predictability of future gene and cell therapies that are used to treat diseases such...

Expanding the View of how Mutations Impact Cells with a High-throughput Approach ‘Perturb-seq’

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Cancer_cells_spectrum_v2_0
Scientists from Broad Institute of MIT and Harvard, discovered an approach to study functional implications of the millions of mutations linked to cancer by pooled Perturb-seq and measuring the impact of TP53 and KRAS variants on RNA profiles in single cancer cells. Precision medicine entails predicting how specific genetic variants affect a patient's health. However, even within recognized cancer genes,...

EMBL’s Scientists Modeled Molecular Complexes Inside Cells at Atomic Resolution Using Modern Software and Cryo-electron Tomography

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NPC-journey-thumbnail1000x600
To better comprehend the function of cells, scientists examine how different components of a cell – from single molecules to several organelles – work in synchronization. They studied individual molecules using classic structural biology tools, honing individual atoms. However, this method yields only static photographs of molecules in most circumstances. Instead, the scientists used cryo-electron tomography to determine how...

‘Valves in DNA’ Created to Shape the Flow of Biological Information

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DNA valve controlling molecular processes along DNA
New biological components developed by scientists at the University of Bristol can alter the flow of cellular activities along DNA. The scientists provide new insights into how information is encoded in DNA and new tools for developing sustainable biotechnologies, in the research published in the journal Nature Communications. Transcriptional terminators tell RNA polymerases (RNAPs) when to stop transcribing and dissociate...

‘Lab on a Chip’ for Measuring Protein-DNA Interactions

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Lab on a Chip
Cornell researchers have invented new nanophotonic tweezers that can fit on a smaller than one inch square chip, making it easier and more efficient to control single molecules using light to study biological systems. In a paper published in Nature Communications, Michelle Wang, the James Gilbert White Distinguished Professor in Physical Sciences in the College of Arts and Sciences, and...

Genome-Scale Protein Structure and Function Prediction with High-Performance Computing Toolkit

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Genome-Scale Protein Structure and Function Prediction
A group of scientists from the Department of Energy's Oak Ridge National Laboratory (ORNL) and the Georgia Institute of Technology applied supercomputing and new deep learning technologies (Google's DeepMind) to anticipate the structures and functions of an organism's whole proteome. The deep learning-based algorithms developed by the team predict protein structure and function from DNA sequences. The discovery may help...

Modeling Protein Fitness Using Evolutionary and Assay-Labeled Data

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Modeing Protein Fitness
Scientists from the University of California, Berkeley have developed a machine learning-based model that predicts protein fitness from the sequence. Protein fitness is a broad term that includes a wide range of protein properties, such as stability, enzyme activity, and ligand binding. Models of protein fitness based on machine learning typically learn from either unlabeled, evolutionarily related sequences or variant...

iDIRECT – A Framework for Analyzing Network Interactions in Various Complex Biological Systems

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Scientists from the University of Oklahoma and University of California at Berkeley have developed a framework iDIRECT (Inference of Direct and Indirect Relationships with Effective Copula-based Transitivity) for disentangling direct and indirect relationships in association networks. Despite the importance of networks in understanding the behavior and features of complex systems, recreating networks from large-scale experimental data is intricate. In systems biology...

Structure Modeling with a New Method Mapped 500 Previously Unsolved Proteins

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Structure Prediction with a New Model Mapped 500 Previously Unsolved Proteins
Pathogens employ virulence factors called effectors, which are critical for their survival. Homology modeling is one of the most extensively used approaches; however, it necessitates the usage of templates of solved effector structures, and solving all of them is far too difficult. There are just too many effector proteins encoded in pathogen genomes for each structure to be solved...

Must Read

Microbiome

A New Sequencing Technique Developed for Low-Biomass, Degraded, or Contaminated Microbiome Samples

0
A low-cost metagenome sequencing technology has been developed by scientists from the Chinese Academy of Sciences' Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT)....
landing-therapeutic-genes

Safely Inserting Therapeutic Genes into the Human DNA

0
Researchers from Harvard's Wyss Institute, Harvard Medical School, and the ETH Zurich have predicted and validated genetic safe harbors for therapeutic genes, making gene...
Cancer_cells_spectrum_v2_0

Expanding the View of how Mutations Impact Cells with a High-throughput Approach ‘Perturb-seq’

0
Scientists from Broad Institute of MIT and Harvard, discovered an approach to study functional implications of the millions of mutations linked to cancer by...
NPC-journey-thumbnail1000x600

EMBL’s Scientists Modeled Molecular Complexes Inside Cells at Atomic Resolution Using Modern Software and...

0
To better comprehend the function of cells, scientists examine how different components of a cell – from single molecules to several organelles – work...
DNA valve controlling molecular processes along DNA

‘Valves in DNA’ Created to Shape the Flow of Biological Information

0
New biological components developed by scientists at the University of Bristol can alter the flow of cellular activities along DNA. The scientists provide new insights...
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