NGS

Bioinformatics | News | NGS | OMICS | Paper Summary | RNA-Seq | Transcriptomics | Trending
Bioinformatics Approaches used in Single-cell Technologies: Recent Progress and Future Directions in Applied Research
ByRiya Vishwakarma December 20, 2022December 20, 2022
Researchers from China examined the experimental and bioinformatics approaches used in single-cell research as well as their applications in a variety of industries, thereby predicting future developments in single-cell technology. A growing number of single-cell technologies have been introduced in past years. Large-scale initiatives like the Human Cell Atlas, Mouse Cell Atlas, Mouse RNA Atlas,…
Read More Bioinformatics Approaches used in Single-cell Technologies: Recent Progress and Future Directions in Applied Research
Bioinformatics | Infectious Diseases | News | NGS | Paper Summary | Tools | Trending
TransFlow: a Fast and Efficient Snakemake Workflow for Whole Genome Sequencing Based Transmission Analysis of Mycobacterium tuberculosis
ByRiya Vishwakarma December 9, 2022December 10, 2022
TransFlow (Transmission Workflow), a convenient, quick, effective, and thorough WGS-based transmission analysis pipeline, is presented by Chinese researchers. TransFlow integrates a number of cutting-edge technologies to perform transmission analysis on raw sequencing data. This analysis includes quality control, sequence alignment, variant calling, downstream transmission grouping, transmission network reconstruction, and transmission risk factor inference. TransFlow is…
Read More TransFlow: a Fast and Efficient Snakemake Workflow for Whole Genome Sequencing Based Transmission Analysis of Mycobacterium tuberculosis
Bioinformatics | Metabolomics | News | NGS | OMICS | Sequencing | Trending
A Multi-Omics Approach to Earth’s Microbiomes Project Demonstrates Microbial and Metabolite Diversity
ByRiya Vishwakarma December 5, 2022December 5, 2022
Contrasting sharply with the little knowledge of the microbial world’s underlying structure is the rising awareness of its significance and variety. Despite recent developments in DNA sequencing, the establishment of general conclusions regarding microbial life on Earth is hampered by the absence of standardized techniques and shared analytical frameworks. Researchers at the University of California San…
Read More A Multi-Omics Approach to Earth’s Microbiomes Project Demonstrates Microbial and Metabolite Diversity
Bioinformatics | Cancer Research | News | NGS | OMICS | Paper Summary | RNA-Seq | Trending
Scientists Decipher the Molecular Subsets Involved in Brain Metastases of Melanoma
ByShwetha S November 30, 2022November 30, 2022
Researchers used a multi-OMICS technique and targeted sequencing (TargetSeq) to identify the processes that may govern the progression of brain metastases. Regardless of intracranial location, it was found that the expression of E-cadherin (Ecad) or Nerve Growth Factor Receptor (NGFR) progresses tumors into proliferative and therapy-resistant states. The investigation of MAPK inhibitor-naive and refractory melanoma…
Read More Scientists Decipher the Molecular Subsets Involved in Brain Metastases of Melanoma
Bioinformatics | News | NGS | Paper Summary | RNA-Seq | Sequencing | Tools | Trending
RNAlysis: a Gateway into RNA Sequencing Data Analysis for Less Computer-savvy Researchers
ByRiya Vishwakarma November 29, 2022November 29, 2022
Qualitative data analysis, understanding patterns, finding possible targets/candidates, and intuitively displaying the results are among the crucially difficult aspects of next-generation sequencing experiments. These challenges are even more difficult for researchers who are not accustomed to writing computer code because the bulk of the analysis tools accessible demand programming knowledge. A customizable Python-based analysis program…
Read More RNAlysis: a Gateway into RNA Sequencing Data Analysis for Less Computer-savvy Researchers
Bioinformatics | Infectious Diseases | Metagenomics | News | NGS | Paper Summary | Trending
Enhancing the Comprehensive Diagnosis of Neonatal Infectious Diseases Through Metagenomic Next-Generation Sequencing
ByShwetha S November 26, 2022November 26, 2022
Scientists from Xi’an Children’s Hospital have shown that metagenomic next-generation sequencing (mNGS) of cell-free DNA (cfDNA) and RNA may help detect trace infections from various bodily fluids and blood samples extracted from newborns. Researchers also performed a local polynomial regression fitting analysis, which revealed that the best time for detecting mNGS was 1 to 3…
Read More Enhancing the Comprehensive Diagnosis of Neonatal Infectious Diseases Through Metagenomic Next-Generation Sequencing
Big Data | Bioinformatics | News | NGS | Paper Summary | RNA-Seq | Tools | Transcriptomics | Trending
Multi-platform Universal Single-cell RNAseq Data Processing Pipeline – UniverSC
ByRiya Vishwakarma November 23, 2022November 23, 2022
Scientists at the Center for Integrative Medical Sciences Yokohama, Japan, designed a platform-independent application to run UniverSC, a wrapper for the 10X Genomics CellRanger program that works with different single-cell technologies, via a graphical user interface, operable on macOS, Windows, and Linux Ubuntu, eliminating data processing for single-cell RNAseq (scRNAseq) analysis for researchers who are naive to…
Read More Multi-platform Universal Single-cell RNAseq Data Processing Pipeline – UniverSC
Bioinformatics | Cancer Research | Drug Discovery | News | NGS | OMICS | Paper Summary | Precision Medicine | Trending
A Bioinformatics Roadmap for Drug Prioritization from Cancer Genomics Data
ByRiya Vishwakarma November 18, 2022October 22, 2026
Cancer is a complicated disease brought on by the interaction of various informational layers. Tumor origin, the appearance of genomic and transcriptomic variations, or interactions with the microenvironment are all factors that contribute to the difficulty of treating tumors. With reference to the types of tumor heterogeneity and the accessible data from next-generation sequencing, the…
Read More A Bioinformatics Roadmap for Drug Prioritization from Cancer Genomics Data
Bioinformatics | Covid-19 News | News | NGS | Paper Summary | RNA-Seq | SARS-CoV-2 | Structural Biology
Researchers Elucidated the Dynamic RNA Structurome and its Potential in Targeted Therapeutics
ByMahi Sharma November 14, 2022November 29, 2022
With a thorough potential of the Ribonucleic Acids (RNA) in cellular processes, the molecule is deemed more than just being transitionary and has emerged as a master regulator of cellular processes. The regulatory functions to code proteins and untranslated regions in mRNA significantly contribute towards post-translational modifications. A review published in Nature Reviews Genetics gives biological insights…
Read More Researchers Elucidated the Dynamic RNA Structurome and its Potential in Targeted Therapeutics
Bioinformatics | Genomics | News | NGS | Paper Summary | Sequencing | Trending
Scientists Unveil High-Resolution Reference Genome of Nile Rat – A Promising Animal Model for Diabetes Research
ByShwetha S November 13, 2022November 13, 2022
A research team led by Yury V. Bukhman from the Morgridge Institute for Research has put forth a reference genome with haplotype-resolved assemblies and gene annotations deciphering the Nile Rat (Arvicanthis niloticus) as a carbohydrate-sensitive model for diabetes research. An animal model is a living, genetically engineered organism used for research and investigating human diseases….
Read More Scientists Unveil High-Resolution Reference Genome of Nile Rat – A Promising Animal Model for Diabetes Research
Bioinformatics | Cancer Research | Genomics | News | NGS | Paper Summary | RNA-Seq | Sequencing | Trending
A Novel CRISPR-based Technique ‘MACHETE’ Investigates Copy Number Alterations in Cancer Genome
ByMahi Sharma November 12, 2022January 10, 2024
The post-doctoral researchers from Memorial Sloan Kettering Cancer Centre (MSK) developed an upfront and coherent way to study copy number alterations (CNA) deletions in the laboratory using the pancreatic and melanoma cancer mouse models. The CRISPR-based method revealed clinically relevant observations into the multifaceted nature of 9p21.3 ommissions that contribute to up to 15% of…
Read More A Novel CRISPR-based Technique ‘MACHETE’ Investigates Copy Number Alterations in Cancer Genome
Bioinformatics | Computational Models | Genomics | Metagenomics | News | NGS | Paper Summary | Sequencing | Tools | Trending
Researchers Develop a Computational Tool ‘CAMMiQ’ for Strain Level Microbial Detection and Quantification Using High Throughput Sequencing Data
ByMahi Sharma November 5, 2022November 5, 2022
A recent study led under the supervision of Cenk Sahinalp et al. and conducted jointly at the National Institute of Health, UCSD, and Indiana University introduced an optimized framework for strain-level microbial identification. The team has provided a comparative approach with reference to other taxonomic classifiers and embedded results with higher sensitivity and specificity. Introduction…
Read More Researchers Develop a Computational Tool ‘CAMMiQ’ for Strain Level Microbial Detection and Quantification Using High Throughput Sequencing Data
Bioinformatics | Chronic Diseases | Machine Learning | Metagenomics | News | NGS | Paper Summary
Accurate Sepsis Diagnosis using Integrated Host-Microbe Plasma Metagenomics Profiling
ByMahi Sharma October 28, 2022October 28, 2022
Sepsis is a life-threatening condition damaging multiple organs at a time due to the host’s aberrant immune responses against infections. The current study supported by the National Heart, Lung, and Blood Institute was conducted at the University of California, San Francisco, USA, to apply an integrated host-microbe metagenomics approach to accurately diagnose potential sepsis in…
Read More Accurate Sepsis Diagnosis using Integrated Host-Microbe Plasma Metagenomics Profiling
Bioinformatics | Cancer Research | COVID-19 | GWAS | Health | News | NGS | Paper Summary | RNA-Seq | Transcriptomics | Trending
Single-cell RNA Sequencing and GWAS Data Integration Discover New Disease Cell Types and Pathways
ByShwetha S October 18, 2022October 18, 2022
A brand-new framework called sc-linker has been proposed by researchers from the Broad Institute of MIT and Harvard that connects human illness and phenotypes to different cell types and physiological processes. This is done by integrating Genome-Wide Association Studies summary statistics, epigenomic data, and single-cell RNA (scRNAseq) sequence data from multiple tissues, cells, diseases, and…
Read More Single-cell RNA Sequencing and GWAS Data Integration Discover New Disease Cell Types and Pathways
Bioinformatics | Data Science | News | NGS | OMICS | Paper Summary | RNA-Seq | Sequencing | Trending
In a Benchmark Study, Scientists Investigated the Integration of Temporal Sequencing Modalities for Trajectory Inference and Disease Prediction
ByMahi Sharma October 2, 2022October 1, 2022
Recent advancements in trajectory inferences have unfolded a new side of bioinformatics, i.e., single-cell analysis. The research group from the University of Northern Carolina School of Medicine benchmark study addressed gaps in capturing temporal changes in a single-cell state. Interpretation of dynamic phenotypes using ten datasets spanning different biological environments at three distinct temporal stages….
Read More In a Benchmark Study, Scientists Investigated the Integration of Temporal Sequencing Modalities for Trajectory Inference and Disease Prediction
AMR Alert | Bioinformatics | Infectious Diseases | Machine Learning | Metagenomics | News | NGS | Paper Summary | Trending
Scientists Investigated Microbial Communities and Resistomes in Relation to Interconnected Humans, Soil, and Livestock
BySrishti Sharma September 27, 2022September 27, 2022
Antimicrobial resistance (AMR) may be reservoired in intensive livestock farms, posing a threat to surrounding communities. The gut microbiome of livestock, workers, and their households, as well as microbial communities in carcasses and soil, were investigated using shotgun metagenome sequencing, machine learning (ML), and culture-based methods at a poultry farm in China. In this study,…
Read More Scientists Investigated Microbial Communities and Resistomes in Relation to Interconnected Humans, Soil, and Livestock
Bioinformatics | Cancer Research | News | NGS | Paper Summary | Sequencing | Trending
Mathematical Modeling Bridges Chromatin Architecture with Potential in Genome Medicine
ByMahi Sharma September 26, 2022September 26, 2022
Scientists from the University of Michigan employed hypergraph theory, utilizing long sequence reads to map genome-wide multi-ways to identify chromatin architecture within the human genome. Understanding how a cell is organized could help biologists develop treatments that halt cancer and other diseases. The kinetics of high-order chromatin composition is known to play a role in…
Read More Mathematical Modeling Bridges Chromatin Architecture with Potential in Genome Medicine
Bioinformatics | Metagenomics | News | NGS | Paper Summary | Sequencing | Trending
Microbiome Data Analysis using Differential Abundance Methods – A Benchmark Study
BySrishti Sharma September 22, 2022September 22, 2022
In order to perform an extensive benchmarking of the known tools for differential abundance analysis, the researchers from the University of Padova used a simulator of microbiome data to create a simulation framework based on microbiome data. This is the first step towards the development of a robust, reliable, and fair simulation framework that will…
Read More Microbiome Data Analysis using Differential Abundance Methods – A Benchmark Study
Bioinformatics | Cancer Research | News | NGS | OMICS | Paper Summary | RNA-Seq | Tools | Trending
Cancer Omics Data Analysis Simplified with a Graphical Interface-driven Bioinformatics Pipeline ‘iCOMIC’
BySrishti Sharma September 10, 2022January 3, 2024
Researchers from the Indian Institute of Technology, Madras, present iCOMIC, a tool for quickly analyzing genomic data. With iCOMIC, users can analyze whole genome and exome sequencing data as well as RNA-Seq data using several pre-configured workflows. Developed as an open-source, standalone tool characterized by a Python-based GUI and automated bioinformatics pipelines for DNA-Seq and…
Read More Cancer Omics Data Analysis Simplified with a Graphical Interface-driven Bioinformatics Pipeline ‘iCOMIC’
Bioinformatics | Cancer Research | News | NGS | Paper Summary | RNA-Seq | Trending
UCI Scientists Track Transposable Elements ‘Parasitic Genes’ in the Search for Disease Treatments
BySrishti Sharma August 27, 2022August 27, 2022
Scientists at the University of California, Irvine, provide new insights into “parasitic genes” or transposable elements. Despite accounting for more than half of human DNA, there is still much to learn about these elements. The new perspective could one day aid in the fight against cancer and aging-related diseases. The transposable element (TE) is an…
Read More UCI Scientists Track Transposable Elements ‘Parasitic Genes’ in the Search for Disease Treatments
Bioinformatics | Cancer Research | Data Science | News | NGS | RNA-Seq | Trending
Scientists Developed a Versatile Pipeline ‘scAmpi’ for Single-cell RNA-seq Data Analysis from Basics to Clinics
ByTanveen Kaur August 17, 2022August 17, 2022
Scientists from the Swiss Institute of Bioinformatics devise a workflow known as Single Cell Analysis mRNA Pipeline, ‘scAmpi,’ for providing complete functionality to scRNA-seq data analysis. In order to understand tissue composition at the single-cell level, to shed light on disease processes, tumor heterogeneity, and the condition of the immune milieu, single-cell RNA sequencing (scRNA-seq) has…
Read More Scientists Developed a Versatile Pipeline ‘scAmpi’ for Single-cell RNA-seq Data Analysis from Basics to Clinics
Bioinformatics | Genomics | News | NGS | OMICS | Sequencing | Trending
Scientists from Seven Bridges Genomics Show how Utilizing Population-Specific Genome Graphs Improves High-throughput Sequencing Data Analysis
ByTanveen Kaur August 10, 2022August 11, 2022
Seven Bridges Genomics, USA, scientists demonstrate an approach for iteratively augmenting tailored genome graphs for targeted populations on whole-genome samples of African ancestry. Due to the current human genome reference’s inadequacy in representing the varied genetic information from various human populations and its incapability to maintain the same level of accuracy for non-European ancestries, graph-based…
Read More Scientists from Seven Bridges Genomics Show how Utilizing Population-Specific Genome Graphs Improves High-throughput Sequencing Data Analysis
Bioinformatics | Database | Genomics | News | NGS | Sequencing | Trending
The UK Biobank Released the Largest Set of Whole Genome Sequences Together with Population Genetics and Trait Association Studies for 150,119 Individuals
ByTanveen Kaur July 26, 2022November 11, 2022
Scientists discuss the study of 150,119 people’s whole genomes from the UK Biobank, which is a group of high-quality variants that includes 58,707,036 indels and 585,040,410 single-nucleotide polymorphisms, or 7.0 percent of all potential single-nucleotide polymorphisms in humans. A thorough and trustworthy characterization of both sequences and phenotypic variation is necessary to gain a thorough…
Read More The UK Biobank Released the Largest Set of Whole Genome Sequences Together with Population Genetics and Trait Association Studies for 150,119 Individuals
Bioinformatics | Corona Virus | COVID-19 | Covid-19 News | Genomics | News | NGS | Paper Summary | Sequencing | Trending
Scientists Devised a Bioinformatics Method ‘COJAC’ for Early Detection and Surveillance of SARS-CoV-2 Genomic Variants in Wastewater
ByTanveen Kaur July 21, 2022November 11, 2022
Using read pairs with several SARS-CoV-2 variant-specific signature mutations as a reliable signal of low-frequency variants, scientists develop the bioinformatics technique known as COJAC (Co-Occurrence adjusted Analysis and Calling). The genomic sequencing, in conjunction with COJAC, can offer population-level estimates of the prevalence and fitness of emerging variants from wastewater samples earlier and on the basis…
Read More Scientists Devised a Bioinformatics Method ‘COJAC’ for Early Detection and Surveillance of SARS-CoV-2 Genomic Variants in Wastewater
Bioinformatics | Cancer Research | News | NGS | Sequencing | Trending
NT-seq – A New Sequencing Technique for Genome-Wide Mapping of Different Types of DNA Methylation
ByDr. Tamanna Anwar July 3, 2022July 3, 2022
Baylor College of Medicine researchers introduce a new sequencing technique ‘NT-seq’ for simultaneously mapping all three forms of DNA methylation. All known methylation motifs in Escherichia coli and Helicobacter pylori genomes were reliably detected by NT-seq, which may also be utilized to find de novo methylation motifs. NT-seq offers a quick and effective way for genome-wide mapping of different…
Read More NT-seq – A New Sequencing Technique for Genome-Wide Mapping of Different Types of DNA Methylation
Bioinformatics | Infectious Diseases | News | NGS | Sequencing | Tools | Trending
Computer Scientists from Rice University Develop a Software ‘Emu’ for Accurate Microbial Community Profiling
ByDr. Tamanna Anwar July 1, 2022July 1, 2022
Emu, an approach that uses an expectation-maximization algorithm to generate taxonomic abundance profiles from full-length 16S rRNA reads profiles microbial populations using common genes. According to results generated from simulated datasets and mock communities, Emu is capable of accurate microbial community profiling while obtaining fewer false positives and false negatives than alternative approaches, When determining…
Read More Computer Scientists from Rice University Develop a Software ‘Emu’ for Accurate Microbial Community Profiling
Bioinformatics | Chronic Diseases | News | NGS | RNA-Seq | Trending
Single-Cell Map of Heart Failure Provides Insights into Novel Potential Therapeutic Targets and Biomarkers
ByDr. Tamanna Anwar June 29, 2022June 29, 2022
Researchers have discovered molecular fingerprints that lead to biological causes of disease by analyzing individual cardiac cells from heart failure patients. Heart failure is an increasingly important public health issue because it comprises a diverse range of clinical characteristics that are all related to reduced heart contractile function. By performing single-nucleus RNA sequencing on nearly…
Read More Single-Cell Map of Heart Failure Provides Insights into Novel Potential Therapeutic Targets and Biomarkers
Bioinformatics | News | NGS | RNA-Seq | Sequencing | Trending
TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition
ByDr. Tamanna Anwar June 28, 2022June 28, 2022
The emergence of single-cell RNA sequencing (scRNA-seq) has now made it possible to analyze the internal workings of hundreds of cells at once, revolutionizing biology and medicine. However, the limitations of scRNA-seq methods include the potential for inaccurate cell composition analysis and the ineffectiveness of complementary DNA (cDNA) amplification, which is the process by which…
Read More TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition
Bioinformatics | Cancer Research | News | NGS | RNA-Seq | Trending
Repurposing Progesterone Altering Drug to Diminish the Risk of Severe Triple Negative Breast Cancer
ByDr. Tamanna Anwar June 18, 2022December 28, 2022
According to new research headed by University College London experts existing drugs that affect the impact of the hormone progesterone, such as mifepristone, have been found to reduce the risk of severe triple negative breast cancer in women with a BRCA1 gene mutation. In premenopausal women, breast cancer is the main cause of death. Progesterone…
Read More Repurposing Progesterone Altering Drug to Diminish the Risk of Severe Triple Negative Breast Cancer
Bioinformatics | Cancer Research | Drug Discovery | News | NGS | RNA-Seq | Structural Biology | Trending
Scientists Synthesize a New Molecule with the Ability to Kill a Broad Spectrum of Hard-to-Treat Cancers
ByDr. Tamanna Anwar June 14, 2022October 22, 2026
Scientists have developed ERX-41, a potent therapeutic drug with a well-defined molecular target (Lysosomal Acid Lipase, LAL) and mechanism of action (disruption of protein folding and production of ER stress) that could be useful in the treatment of patients with multiple solid cancers (Hard to Treat Cancers). Scientists from the University of Texas, Dallas synthesized…
Read More Scientists Synthesize a New Molecule with the Ability to Kill a Broad Spectrum of Hard-to-Treat Cancers
Bioinformatics | Data Science | Featured | Genomics | News | NGS | Sequencing | Tools | Trending
Scientists Use CRISPR Technology and Perturb-seq to Map Every Human Gene to its Function
ByDr. Tamanna Anwar June 11, 2022June 18, 2022
Scientists from Whitehead Institute and collaborators used Perturb-seq, a single-cell sequencing technology, to link every expressed gene in the human genome to its function in the cell, offering a free resource for other researchers that can be accessed via the internet. The Human Genome Project was a huge undertaking that aimed to sequence every single…
Read More Scientists Use CRISPR Technology and Perturb-seq to Map Every Human Gene to its Function
AMR Alert | Antibiotic Resistance | Bioinformatics | Infectious Diseases | News | NGS
Scientists Discover Superbug Develops Drug-Resistance to ‘last Resort’ Antibiotic Fast
ByDr. Tamanna Anwar June 9, 2022June 18, 2022
New research from University of Oxford revealed that superbug Pseudomonas develops resistance to a common ‘last-resort’ antibiotic much faster than expected. Recent research published in Cell Reports this week shows how populations of the bacterium Pseudomonas react to treatment with Colistin, a ‘last resort’ antibiotic for patients with multidrug-resistant infections. Antibiotics are essential for human health because they help…
Read More Scientists Discover Superbug Develops Drug-Resistance to ‘last Resort’ Antibiotic Fast
Bioinformatics | Cancer Research | News | NGS | Paper Summary | Precision Medicine | Trending
PGDx Elio Tissue Complete – An Automated and FDA-Approved Clinical Genomics Assay for Comprehensive Genomic Profiling of Human Cancer
ByTanveen Kaur May 30, 2022November 9, 2022
PGDx Elio tissue complete, which the FDA has approved for the analysis of 505 cancer-related genes, will enable the development of more effective precision oncology treatment options. The researchers from Personal Genome Diagnostics Inc. (PGDx) explain the developmental and analytical validation processes of the PGDx elio tissue complete test. It is an automated NGS-based approach…
Read More PGDx Elio Tissue Complete – An Automated and FDA-Approved Clinical Genomics Assay for Comprehensive Genomic Profiling of Human Cancer
Bioinformatics | News | NGS | RNA-Seq | Sequencing | Trending
Resistance Genes Identified can Predict Response to Arthritis Treatment and Lays Foundation for Future Drug Development
ByDr. Tamanna Anwar May 22, 2022June 18, 2022
Researchers from the Queen Mary University of London have shown that molecular profiling of diseased joint tissue can significantly impact whether specific medication treatments will work to treat rheumatoid arthritis (RA) patients. The researchers also discovered certain genes linked to resistance to most available medications, a condition known as refractory illness, which could lead to…
Read More Resistance Genes Identified can Predict Response to Arthritis Treatment and Lays Foundation for Future Drug Development
Algorithm | Bioinformatics | Genomics | Machine Learning | News | NGS | Sequencing | Tools | Trending
‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up DNA Sequencing
ByDr. Tamanna Anwar May 21, 2022June 18, 2022
The algorithm is the first full-fledged machine learning-based short read alignment algorithm to speed up DNA sequencing, that efficiently uses learned indices to solve the exact match search issue for efficient seeding. The human genome is made up of a whole set of DNA that is around 6.4 billion letters long. Reading the entire genome…
Read More ‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up DNA Sequencing
AMR Alert | Antibiotic Resistance | Bioinformatics | Metagenomics | News | NGS | Sequencing | Trending
Impact of Antibiotics on the Evolution of Gut Microbiome and Antimicrobial Resistance
ByDr. Tamanna Anwar May 13, 2022June 18, 2022
Following a single antibiotic course, the researchers discover how gut commensals acquire antimicrobial resistance genes (ARGs). According to the researchers, a single round of antibiotics may be enough to drive ARG acquisition and occurrence in gut commensals throughout the duration of a mammalian lifetime. Antibiotics are frequently used to treat infections and ensure surgical treatments…
Read More Impact of Antibiotics on the Evolution of Gut Microbiome and Antimicrobial Resistance
Bioinformatics | News | NGS | RNA-Seq | Sequencing | Transcriptomics | Trending
Single Cell RNA Sequencing Determines 16 Distinct Cell Populations in a Key Brain Area for Substance Use Disorders
ByDr. Tamanna Anwar April 21, 2022November 25, 2023
The University of Alabama in Birmingham researchers have found 16 unique cell populations in a complex part of the midbrain known as the ventral tegmental area, or VTA, using single-cell RNA sequencing in a study that advances the field. Expanding our understanding of the VTA’s function will help us better understand the mechanisms behind substance…
Read More Single Cell RNA Sequencing Determines 16 Distinct Cell Populations in a Key Brain Area for Substance Use Disorders
Bioinformatics | COVID-19 | Covid-19 News | GWAS | NGS | RNA-Seq | Sequencing | Trending
First Cell Transcriptomic Atlas of a Non-Human Primate Completed by an International Team Led by BGI
ByDr. Tamanna Anwar April 15, 2022June 18, 2022
Researchers from BGI-Research, in collaboration with scientific research teams from China, Germany, Italy, Singapore, Spain, Sweden, and the United Kingdom, published the world’s first non-human primate whole-body cell transcriptomic atlas in the scientific journal Nature this week, in a breakthrough that could lead to scientific advancement in the treatment of human diseases. The study will…
Read More First Cell Transcriptomic Atlas of a Non-Human Primate Completed by an International Team Led by BGI
Bioinformatics | Biotech | Data Science | Featured | Genomics | News | NGS | Paper Summary | Precision Medicine | Trending
Scientists Revealed the First Complete, Gapless Human Genome Sequence ‘T2T-CHM13’
ByDr. Tamanna Anwar April 6, 2022June 18, 2022
An international group of scientists has finally published the whole human genome sequence. The new reference genome fills in gaps left by previous versions, allowing researchers to understand better genetic variation and how it can contribute to disease in specific cases. The complete human genome sequence has already provided new perspectives to genome biology and…
Read More Scientists Revealed the First Complete, Gapless Human Genome Sequence ‘T2T-CHM13’
Bioinformatics | Cancer Research | Health | News | NGS | Paper Summary | Precision Medicine | Trending
Scientists Design a Whole-Genome Risk Prediction of Common Diseases in the Human Preimplantation Embryos
ByTanveen Kaur March 30, 2022November 25, 2023
Preimplantation genetic testing (PGT) of embryos fertilized in-vitro has been proposed as a strategy to diminish transmission of common diseases; in any case, a more comprehensive embryo genetic assessment, joining the impacts of common variants and rare variants, stays inaccessible. In this study, the scientists used molecular and statistical techniques to infer inherited genome sequence…
Read More Scientists Design a Whole-Genome Risk Prediction of Common Diseases in the Human Preimplantation Embryos
Bioinformatics | Gene Expression | News | NGS | RNA-Seq | Sequencing
Scientists Discovered ‘Junk DNA’ as the Key to Controlling Fear
ByDr. Tamanna Anwar March 29, 2022June 18, 2022
Scientists from the University of Queensland found, a bit of “junk DNA” could be the key to eradicating fear-related memories in persons suffering from post-traumatic stress disorder (PTSD) and phobia. While researching how the genome responds to traumatic experiences, an international research effort led by Associate Professor Dr. Timothy Bredy of the Queensland Brain Institute…
Read More Scientists Discovered ‘Junk DNA’ as the Key to Controlling Fear
Bioinformatics | News | NGS | OMICS | Paper Summary | RNA-Seq | Sequencing | Trending
Scientists from the University of Helsinki Developed a Computational Platform ‘ScType’ for Fully Automated and Super Quick Identification of Cell-Type
ByTanveen Kaur March 17, 2022November 9, 2022
The researchers developed a computational platform ScType, which empowers a completely mechanized and super quick cell-type distinguishing proof-dependent exclusively upon given scRNA-seq information, alongside a thorough cell marker data set as foundation data. Utilizing six scRNA-seq datasets from different human and mouse tissues, it was shown how ScType gives fair-minded and precise cell type explanations…
Read More Scientists from the University of Helsinki Developed a Computational Platform ‘ScType’ for Fully Automated and Super Quick Identification of Cell-Type
Bioinformatics | Corona Virus | COVID-19 | Covid-19 News | Data Science | NGS | Trending
Computer Scientists from Rice University Develop a Program ‘Variabel’ to Find ‘Low-Frequency’ Variants in Sequence Data
ByDr. Tamanna Anwar March 15, 2022June 18, 2022
Variabel, a novel approach and first method designed for rescuing low frequency intra-host variants from Oxford Nanopore Technologies (ONT) data alone. Details about variants hidden in the deluge of genetic SARS-CoV-2 sequences might be helpful if researchers can find them. A new program developed at Rice University’s George R. Brown School of Engineering will make…
Read More Computer Scientists from Rice University Develop a Program ‘Variabel’ to Find ‘Low-Frequency’ Variants in Sequence Data
AI | Bioinformatics | Data Science | Deep Learning | Genomics | Machine Learning | Neural Network | News | NGS | Tools | Trending
Scientists from the University of California Developed a Highly Accurate Algorithm ‘La Jolla Assembler (LJA)’ to Scale-up Complete Genome Assembly
ByDr. Tamanna Anwar March 12, 2022June 18, 2022
A team of international researchers led by the University of California San Diego’s Department of Computer Science and Engineering has demonstrated that the La Jolla Assembler (LJA), a new genome assembly algorithm, vastly improves large genome reconstruction, the process of arranging DNA snippets into complete genomes, which is a crucial part of genomic sequencing. Furthermore,…
Read More Scientists from the University of California Developed a Highly Accurate Algorithm ‘La Jolla Assembler (LJA)’ to Scale-up Complete Genome Assembly
Bioinformatics | Drug Discovery | Featured | Genomics | News | NGS | OMICS | Precision Medicine | Tools | Trending
Scientists at Garvan Institute Developed a Single Test for Over 50 Genetic Diseases, Cutting Diagnosis Time from Decades to Days
ByDr. Tamanna Anwar March 11, 2022October 22, 2026
Garvan Institute researchers have demonstrated how new genomic sequencing technologies might help individuals with uncommon neurological and neuromuscular conditions avoid a “diagnostic odyssey.” – A single DNA test capable of screening a patient’s genome for over 50 genetic neurological and neuromuscular diseases (e.g., Huntington’s disease, muscular dystrophies, and fragile X syndrome) has been developed. -…
Read More Scientists at Garvan Institute Developed a Single Test for Over 50 Genetic Diseases, Cutting Diagnosis Time from Decades to Days
AI | Bioinformatics | Genomics | Health | News | NGS | Trending
Fastest DNA Sequencing that Uses AI and Accelerated Computing Sets Guinness World Record For Completing DNA Sequencing in Just Five Hours and Two Minutes
ByDr. Tamanna Anwar February 27, 2022June 18, 2022
Stanford University researchers established the record in collaboration with NVIDIA, Oxford Nanopore Technologies, Google, Baylor College of Medicine, and the University of California, Santa Cruz. This week, Guinness World Records awarded a Stanford University-led research team the first record for quickest DNA sequencing technology — a benchmark established utilizing a workflow enhanced by AI and…
Read More Fastest DNA Sequencing that Uses AI and Accelerated Computing Sets Guinness World Record For Completing DNA Sequencing in Just Five Hours and Two Minutes
Bioinformatics | Genomics | News | NGS | RNA-Seq | Trending
Entire Human Gut Mapped by Scientists at the Single-Cell Resolution
ByDr. Tamanna Anwar February 25, 2022June 18, 2022
Scientists from the University of North Carolina School of Medicine, led by Scott Magness, Ph.D., sequenced the genes expressed in single cells from human digestive tracts to discover new cell-type characteristics and learn more about essential cell functions like nutrient absorption and immune defense. You could feel uneasy in your tummy if you get nervous….
Read More Entire Human Gut Mapped by Scientists at the Single-Cell Resolution
Bioinformatics | Biotech | News | NGS | Sequencing
Mapping the Development of Cell Types and Tissues
ByDr. Tamanna Anwar February 12, 2022June 18, 2022
Researchers at Yale University, in collaboration with Karolinska Institutet in Stockholm, Sweden, have created a technology that allows them to look at epigenetic mechanisms driving tissue formation concurrently at a spatial and genome-wide level, a breakthrough with several scientific and medical applications. While existing technology allows scientists to study epigenetic information in the bulk of…
Read More Mapping the Development of Cell Types and Tissues

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Mapping the Development of Cell Types and Tissues

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