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Scientists Integrate Genome Mining with PAN Genome Analysis to Discover the Potential of Bacterial Compounds and Genes Linked to Colon Cancer-Causing Toxin

Scientists from the Technical University of Denmark (DTU) and the University of California San Diego present a systems biology workflow that integrates genome mining...

Scientists Unravel How DNA Double Helix Structure is Opened to Allow DNA Replication

Scientists at the Francis Crick Institute have uncovered how the DNA double helix structure is opened to allow DNA replication. The research could pave...

Scientists Discover a New Mechanism for Endoplasmic Reticulum Sorting of LRR Receptor Kinases in Arabidopsis

Scientists from the Chinese Academy of Sciences' Institute of Genetics and Developmental Biology (IGDB) have discovered a new mechanism that protects the endoplasmic reticulum...

Scientists Develop Structural 3D Maps of Key Proteins that Go Wrong in Brain Disorders Revealing New Treatment Routes

Cold Spring Harbor Laboratory (CSHL) scientist Professor Hiro Furukawa adopts an architectural approach to brain research. He makes structural 3D maps of key proteins...

Scientists Used a Netflix-Style Algorithm to Create Blueprint of Cancer Genomes

The algorithms that track users' Netflix viewing habits could soon be used to track cancer development in order to direct doctors in managing cancer. An...

Supercomputing Helps Discover Weaknesses in HIV-1 Virus Capsid

There's still a lot to discover about how the HIV-1 virus affects human cells. Scientists believe it gets past our immune system's defenses and...

Repurposing Progesterone Altering Drug to Diminish the Risk of Severe Triple Negative Breast Cancer

According to new research headed by University College London experts existing drugs that affect the impact of the hormone progesterone, such as mifepristone, have...

Disease Prognosis Using Deep Learning and H&E Images – Emerging Tool for Clinical Trial Optimization

Scientists used hematoxylin and eosin (H&E) images with a deep learning approach to predict disease outcomes, an emerging technique for the improvement of clinical trials...

Scientists Develop a New Computational Tool ‘Grit’ to Identify Upstream Transcription Factor Binding Sites More Accurately

Scientists from Yangtze University, Jingzhou, China developed a computational tool, "Grit," to identify the upstream transcription factor binding sites in orthologous genes by the...

Scientists Elucidate How Bacteria Communicate Their Way To Causing Infection

Scientists at Oregon State University revealed how bacteria communicate their way to causing infection. The researchers discovered proteins that prevent a bacterial cell from...

Scientists Synthesize a New Molecule with the Ability to Kill a Broad Spectrum of Hard-to-Treat Cancers

Scientists have developed ERX-41, a potent therapeutic drug with a well-defined molecular target (Lysosomal Acid Lipase, LAL) and mechanism of action (disruption of protein...

Transcriptome-Wide Association Studies Integrated with 3D Genomic and Epigenomic Data used to Improve Target Gene Discovery and Drug Repurposing

Scientists from Pennsylvania State University integrated 3D genomic and epigenomic data with transcriptome-wide association studies data to improve gene expression predictions. The researchers propose an integrative method...

Scientists Use CRISPR Technology and Perturb-seq to Map Every Human Gene to its Function

Scientists from Whitehead Institute and collaborators used Perturb-seq, a single-cell sequencing technology, to link every expressed gene in the human genome to its function...

Scientists Develop a Novel Probabilistic Generative Model ‘RaptGen’ for Aptamer Generation

Scientists from the Graduate School of Advanced Science and Engineering at Waseda University, Japan, developed RaptGen, a variational autoencoder for in silico aptamer generation....

Scientists Develop a New Computer Vision Model with Improved Proficiency to Differentiate Rheumatoid Arthritis from Osteoarthritis in Damaged Joint Tissue

Hospital for Special Surgery (HSS) researchers in New York City have developed a computer vision tool that effectively identifies rheumatoid arthritis (RA) from osteoarthritis...

Scientists Discover Superbug Develops Drug-Resistance to ‘last Resort’ Antibiotic Fast

New research from University of Oxford revealed that superbug Pseudomonas develops resistance to a common 'last-resort' antibiotic much faster than expected.  Recent research published in Cell Reports...

ColabFold: A Freely Accessible Protein Folding Tool for Accelerated Prediction of Protein Structures and Complexes

Scientists have developed ColabFold, an open-source software to accelerate the prediction of protein structures as well as complexes by integrating fast homology search of...

Scientists Discover New Mass Spectrometry-Based Proteomics Method For Early Detection of Liver Diseases

Through mass spectrometry-based proteomics, a German-Danish research team led by Matthias Mann has developed a new screening tool to identify alcohol-related liver disorders at...

Scientists Develop a Novel Approach for Early Disease Diagnosis Using DNA Droplets

Scientists at Tokyo Tech have produced computational DNA droplets that can recognize specific patterns in tumor biomarker microRNA sequences by merging the technologies of...

A New Computer Simulation Coupled with Machine Learning Cracked the Mechanism of Cancer Drug Resistance

A team led by the University of Maryland utilizes machine learning to explain why a "wonder drug" may not work in all patients. Understanding how...

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Heart Failure

Single-Cell Map of Heart Failure Provides Insights into Novel Potential Therapeutic Targets and Biomarkers

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Researchers have discovered molecular fingerprints that lead to biological causes of disease by analyzing individual cardiac cells from heart failure patients. Heart failure is an...
single-cell RNA sequencing, TAS-Seq, RNA Sequencing

TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition

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The emergence of single-cell RNA sequencing (scRNA-seq) has now made it possible to analyze the internal workings of hundreds of cells at once, revolutionizing...
picasso technique

PICASSO Technique Helps Scientists Visualize Biological Molecules into Technicolor​

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Scientists from the Korea Advanced Institute of Science and Technology propose the PICASSO technique, which enables more than 15-color imaging of spatially overlapping proteins...
Antibiotic Resistance

High-Resolution Cryo-EM Structure of Type IV Secretion System Offers New Hope for Fighting Antibiotic...

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A group of researchers from UCL and Birkbeck has discovered a novel strategy to help limit the spread of antibiotic resistance, which has the...
genome structure

Applying 3D Computational Simulation to Reveal the Secrets of the Genome Structure in the...

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A research team from Nagoya University in Japan has created a 3-Dimensional computational simulation of the formation of the genome structure in the human...