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Hierarchical Structure-based Virtual Screening Targeting SARS-CoV-2 Endoribonuclease

Since the first appearance of SARS-CoV-2, a number of in silico methods have been employed to discover possible drugs that can target the viral...

Unveiling Specific Functions of Novel lncRNA Gm20743 using Whole-transcriptome Landscape of Diabetes-related Sarcopenia

Scientists perform the whole-transcriptome RNA sequencing and informatics of diabetes-induced sarcopenia model of db/db mice to illustrate the specific function of novel lncRNA Gm20743.  Type...

Decoding Scene Prediction by the Human Brain and its Confidence During Virtual Reality Maze Exploration

Kyoto University scientists have discovered that they can decode from brain activity the subjects' capacities to forecast their placements and scenes within the labyrinth,...

A Deep Unsupervised Language Model ‘ProtGPT2’ for Protein Design

Scientists from the University of Bayreuth, Germany, introduced ProtGPT2, a language model for protein design trained on the protein space that generates de novo...

Graph Based Visualization and Analysis of High Dimensional Data Using the Platform ‘Graphia’

Scientists from the University of Edinburgh developed an open-source platform, 'Graphia', for the graph-based visualization and analysis of the high dimensional data being produced...

DeepBacs: A Deep Learning Approach to Analyze Bacterial Microscopy Images

Scientists from University College London demonstrate the use of various cutting-edge artificial neural networks to analyze images of bacterial microscopy. The approach will help...

SAMchain – A Blockchain Technology for Storing and Analyzing Genomes

Scientists from Yale University developed a novel private blockchain network by employing layered database indexing for the storage of reference-aligned next-generation sequencing reads and individual...

Deepmind’s AlphaFold Revealed the Structures of all the Proteins Known to Science, Expanding the AlphaFold DB by Over 200x

The AlphaFold Protein Structure Database, created by DeepMind and EMBL's European Bioinformatics Institute (EMBL-EBI), makes AI-enabled predictions of the 3D structures of nearly all...

Scientists Develop Digital Pathology Models without Human Intervention by Integrating Clinical Healthcare Data with AI

Scientists unleash the potential of digital pathology data by training computer-aided diagnosis models and making use of convolutional neural networks without human annotations. The...

“Zip Codes” Direct RNA Molecules to Reach their Intended Destinations

Scientists from the Weizmann Institute resolved the mystery of how RNA molecules get to their intended destinations. Each cell in our body receives instructions from...

An ‘Elegant’ Mechanism of Antibiotic Resistance in Golden Staph Revealed by a New Tool

Scientists from the University of New South Wales have discovered a complex system for adaptability in Staphylococcus aureus that has led to the identification and characterization...

The UK Biobank Released the Largest Set of Whole Genome Sequences Together with Population Genetics and Trait Association Studies for 150,119 Individuals

Scientists discuss the study of 150,119 people's whole genomes from the UK Biobank, which is a group of high-quality variants that includes 58,707,036 indels...

Advanced AI in Brain Imaging Captures Dynamic Mental Illness Markers

In order to better prevent and cure debilitating ailments including Alzheimer's disease, schizophrenia, and autism, new research at Georgia State University's TReNDS Center may...

Scientists Device a Biosensor Integrated ‘Smart Necklace’ to Track Health Status Through Sweat

A biosensor integrated smart necklace has been successfully tested by scientists from the Ohio State University and the University of Wisconsin, Madison, that could...

AACR Project GENIE – An International Pancancer Project Strengthening Precision Medicine

The American Association for Cancer Research (AACR) Project GENIE serves as a worldwide precision medicine knowledge base with ever-increasing implications for clinical decision-making as...

AI-Based Early Warning System for Sepsis Prevents Thousands of Deaths

The new AI-based technology developed by the scientists at Johns Hopkins University recognizes patients susceptible to sepsis, which is otherwise notoriously hard to detect...

Scientists Devised a Bioinformatics Method ‘COJAC’ for Early Detection and Surveillance of SARS-CoV-2 Genomic Variants in Wastewater

Using read pairs with several SARS-CoV-2 variant-specific signature mutations as a reliable signal of low-frequency variants, scientists develop the bioinformatics technique known as COJAC...

Replication Stalling and Recovery within Repetitive DNA Plays a Role in the Onset of Cancer

Scientists have discovered that repetitive DNA sequences or non-coding DNA, thought to be harmless and inactive, may play a role in the onset of...

SpaceFlow – A Deep Learning Framework to Integrate Spatiotemporal Information in Analyzing Spatial Transcriptomic Data

Scientists from the University of California Irvine introduced SpaceFlow, which, by the utilization of spatially regularised deep graph networks, combines expression similarity with geographical...

Novel ‘Fuzzy’ AI Algorithms to Help Patients with Memory Loss

Like our brains, a new computer program created by Parham Aarabi of the University of Toronto can store and retrieve information strategically. An experimental tool...

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Population Specific Genome Graphs

Scientists from Seven Bridges Genomics Show how Utilizing Population-Specific Genome Graphs Enhances High-throughput Sequencing...

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Seven Bridges Genomics, USA, scientists demonstrate an approach for iteratively augmenting tailored genome graphs for targeted populations on whole-genome samples of African ancestry.  Due to...
Teixobactin–membrane-interaction

Teixobactin Kills Bacteria by Attacking the Cell Envelope in Two Ways

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The development of new mechanisms for antibiotics is essential to combating antimicrobial resistance. With its unique chemical scaffold, Teixobactin is a new class of...
Scientists Propose a Computational Approach for Predicting HIV Combination Therapy to Prevent Viral Escape and Rebound

Scientists Propose a Computational Approach for Predicting HIV Combination Therapies to Prevent Viral Escape...

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Scientists from the University of Washington, the Max Planck Institute for Dynamics and Self-Organization, and the University of Cologne carefully formulated combination therapies from...
Molecular Dynamics Simulations and Diversity Selection by Extended Continuous Similarity Indices

Scientists Recognize Extended Continuous Similarity Indices as a Novel Tool to Study the Conformational...

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Scientists from the University of Florida, US, and the Research Centre for Natural Science, Hungary, developed a new frame selection algorithm, "ECS-MeDiv," as an...
Long fibrils of teixobactin (yellow arrows) and lipid II (red-blue dots) lead to weak spots in the cell membrane of the bacterium.

Scientists Discover a Novel Two-step Mechanism the Antibiotic ‘Teixobactin’ uses to Kill Antibiotic-Resistant Bacteria

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The University of Utrecht scientists have uncovered a novel mechanism for how drugs eradicate antibiotic-resistant bacteria. Teixobactin, an antibiotic, kills bacteria by destroying their...