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Evaluating 3D Molecular Generative Models: The Impact of GenBench3D on Ligand Conformation Quality

Evaluating specific properties of molecules from simple SMILE strings isn't enough. Instead of simple chalkboard formulae, our aim should be to conjure up three-dimensional...

RNA-FrameFlow: Pioneering 3D RNA Backbone Design with Flow Matching

A part of systems biology is ‘designing RNA structures,’ which entails planning and organizing molecules of RNA into custom 3D formations with particular uses....

Uncovering Tumour Heterogeneity: How Single-cell Technologies are Transforming Cancer Treatment and Drug Development

Single-cell technologies are effective drug development and discovery tools, serving important functions at several phases. They aid in identifying potential therapeutic targets, streamline single-cell...

Unlocking Bacterial Secrets: Highly Multiplexed Spatial Transcriptomics Revolutionizing Microbial Research

In one of the significant research studies, the researchers of Boston Children's Hospital, Harvard Medical School, and Broad Institute of Harvard and MIT, Cambridge,...

Decoding Diversity: How Ethnicity Shapes Our Immune System

A recent study led by researchers from A*STAR explores the interplay between race and the function of the cell. Researchers used healthy blood samples...

Understanding GenSQL: The Enhancement of SQL to Transform Healthcare and Virtual Wet Labs

In today's world, efficiently managing and analyzing vast amounts of data is crucial for various industries. GenSQL, a pioneering system developed by researchers at...

The Protein Interaction Explorer (PIE) Platform: Revolutionizing the Study of Protein-Protein Interactions and Ligand Binding Pockets

A web-based tool called Protein Interaction Explorer (PIE) by researchers from Université de Paris, France, was created to support structure-based drug discovery efforts that center...

The Future of Drug Design: How Machine Learning is Revolutionizing PROTAC Development

As the fight against disease has changed, so have therapeutic strategies. One such new approach is Targeted Protein Degradation (TPD), which attempts to exploit...

Decoding RNA-Protein Interactions: Harnessing Computational Tools for Advanced Predictions without High-Throughput Data

The Central Dogma of Biology describes the process of DNA (Deoxyribonucleic acid) undergoing transcription to form RNA (Ribonucleic acid) and transformation to form proteins...

ZeroDDI: Revolutionizing Drug-Drug Interaction Event Prediction with Zero-Shot Learning

In the context of the field of medical practice, identifying potential DDIs (Drug-drug interactions) is critical in assessing the safety of a patient’s prescribed...

GeneRAG: Taking LLMs a Step Forward with Retrieval-Augmented Generation in Genetic Queries

Large Language Models (LLMs) have greatly revolutionized text generation and comprehension in the world of Natural Language Processing. Nowadays, they can be used for...

MicroWorldOmics –  A One-Stop Pipeline for Microbiome and Virome Analysis

Dr. Runze Li and his colleagues from different institutes in China have recently developed high-tech tools that help researchers navigate through the complexities of...

Supercomputing Simplified with AI: The APACE Approach to Accelerated Discovery in Biophysics

Researchers from the University of Illinois Urbana-Champaign introduce APACE, AlphaFold2, and advanced computing as a service, a computational framework that manages this TB-sized AI...

Dante’s GenomeChat: Your Gateway to Personalized Genomic Insights

Dante Genomics launched Dante GenomeChat, which enables users to receive highly personalized genomic information thanks to advanced technology. A graphical iOS app can access...

BulkRNABert: A New Weapon in the Fight Against Cancer – How AI Reads Genes for Better Prognosis

Recent pioneering research by Université Paris-Saclay and Instadeep scientists has introduced a new technique, BulkRNABert. This method exploits a language model, an artificial intelligence...

Modeling the Perfect Diagnosis with Machine Learning in Ovarian Cancer

Genes are the basic units of heredity, but they only come to life when translated into proteins. The study of the proteins found in...

Accelerating the Path to New Medicines: Monash’s Innovative AI Tool for Fast and Cost-Effective Drug Discovery

Improved identification of interactions between proteins and ligands has been invaluable in the progress of computational biology, potentially enhancing drug discovery and revealing more...

From Complex to Clicks: BiomiX, an Automated Ally for Life Scientists in Multi-Omics Research

A team of researchers from France and Spain designed BiomiX, a user-friendly bioinformatics tool for multiomics data analysis. BiomiX addresses the challenge of multiomics...

AI and Biomedicine: Enhancing Diagnosis with Vision-Language Models

Vision language modeling has been transformed by transformational AI technology called multimodal learning. Technological developments such as multimodal GPT-4V and LLaVA-Med allow for powerful...

AI Tools for Cancer Researchers: Enhancing Productivity and Uncovering New Discoveries

Artificial intelligence (AI) has become widely accessible, transforming from a specialized resource into a common tool for cancer researchers. It is beneficial for every...

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Can Real-Time Genomics Change the Game of Detecting Antibiotic Resistance?

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Antibiotic resistance is increasing as a global problem, meaning previously effective treatments for bacterial infections have ceased to work. It is vital to accurately...
Cracking the Metastasis Code: MetaGXplore's Breakthrough in Pan-Cancer Diagnosis

Cracking the Metastasis Code: MetaGXplore’s Breakthrough in Pan-Cancer Diagnosis

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A significant obstacle to the clinical prognosis is tumor metastasis, or the spread of cancer cells from the original tumor to other locations. The...
Molecular Mechanism of DDM1: How This Plant Protein Silences "Jumping Genes"

Molecular Mechanism of DDM1: How This Plant Protein Silences “Jumping Genes”

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A recent study by Akihisa Osakabe and his colleagues, researchers at the University of Tokyo, elucidated the intriguing dance between plants and their "jumping...
Navigating the Landscape of Enzyme Design: From Molecular Simulations to Machine Learning

Harnessing Computational Tools: How Machine Learning and Molecular Simulations are Transforming Enzyme Design

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Global environmental concerns and the need for sustainable development require new technologies for producing fine chemicals and managing waste efficiently. Nowadays, using enzymes in...
Decoding the Impact of Mutations: Interface-Guided Phenotyping of RUNX1 Transcription Factor Reveals New Insights

Decoding the Impact of Mutations: Interface-Guided Phenotyping of RUNX1 Transcription Factor Reveals New Insights

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Researchers from the University of California deploy SEUSS (scalable functional screening by sequencing), a perturb-seq method, to analyze single-gene missense mutations, which have been...