Bioinformatics Research & News

Japanese scientists from the National Institute of Natural Sciences (NINS) and Osaka University have discovered novel protein folds. They created a well-defined set of rules to predict the structure of unprecedented αβ-folds and then designed those structures through de novo design. All eight predicted structures match the de novo design models. They were also able…

Scientists from Georgia State University, The University of Texas, and Lawrence Berkeley National Laboratory, USA, built models of transcription factor IIH (TFIIH) using cryo-electron microscopy (cryo-EM) to comprehend how it smoothly transitions between performing two vital yet vastly different functions, transcription initiation and nucleotide excision repair (NER). They employed simulations and graph-theoretical analysis and found…