Reassembling the Chromosomes of Earth’s First Creatures
According to the latest research published this week in the journal Science Advances, many modern marine invertebrates, such as sponges and jellyfish, contain chromosomes...
Interpreting Clinical Proteomics Data With A Knowledge Graph
Researchers at the University of Copenhagen, Denmark, introduce the Clinical Knowledge Graph (CKG), an open-source platform with about 20 million nodes and 220 million...
Network Based Computer Modeling Revealed Omicron’s Mechanism of Escaping Antibodies
According to a computational study carried out by researchers at MIT, several mutations in the virus' spike protein enable it to dodge antibodies that...
Artificial Intelligence Model Predicts in Seconds How Two Proteins Will Bind...
Researchers from MIT have developed a machine-learning model that can predict how two proteins bind, not in hours or minutes but just in a...
CellRank: A Tool for Directed Single-Cell Fate Mapping
Researchers from the Helmholtz Centre Munich, Germany, provide CellRank, a method for single-cell fate mapping in a variety of circumstances where the direction is...
HyperAttentionDTI: Combining Sequence-Based Deep Learning with an Attention Mechanism for Drug-Protein...
Researchers of Central South University, Changsha proposed an end-to-end bio-inspired model based on the convolutional neural network (CNN) and attention mechanism, named HyperAttentionDTI, for...
Simulation of a Living Cell Enabled with NVIDIA GPUs
GPU-accelerated software developed by the researchers at the University of Illinois at Urbana-Champaign simulates a 2-billion-atom cell that metabolizes and grows like a biological...
Cloud Computing Helps Researchers Identify Over 100,000 RNA Viruses Including Nine...
A team of scientists led by a former University of British Columbia (UBC) postdoctoral researcher in medical genetics discovered over ten times the number...
A New Sequencing Technique Developed for Low-Biomass, Degraded, or Contaminated Microbiome...
A low-cost metagenome sequencing technology has been developed by scientists from the Chinese Academy of Sciences' Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT)....
Safely Inserting Therapeutic Genes into the Human DNA
Researchers from Harvard's Wyss Institute, Harvard Medical School, and the ETH Zurich have predicted and validated genetic safe harbors for therapeutic genes, making gene...
Expanding the View of how Mutations Impact Cells with a High-throughput...
Scientists from the Broad Institute of MIT and Harvard discovered an approach to studying the functional implications of the millions of mutations linked to...
EMBL’s Scientists Modeled Molecular Complexes Inside Cells at Atomic Resolution Using...
To better comprehend the function of cells, scientists examine how different components of a cell – from single molecules to several organelles – work...
‘Valves in DNA’ Created to Shape the Flow of Biological Information
New biological components developed by scientists at the University of Bristol can alter the flow of cellular activities along DNA.
The scientists provide new insights...
‘Lab on a Chip’ for Measuring Protein-DNA Interactions
Cornell researchers have invented new nanophotonic tweezers that can fit on a smaller than one-inch square chip, making it easier and more efficient to...
Genome-Scale Protein Structure and Function Prediction with High-Performance Computing Toolkit
A group of scientists from the Department of Energy's Oak Ridge National Laboratory (ORNL) and the Georgia Institute of Technology applied supercomputing and new...
Modeling Protein Fitness Using Evolutionary and Assay-Labeled Data
Scientists from the University of California, Berkeley have developed a machine learning-based model that predicts protein fitness from the sequence.
Protein fitness is a broad...
iDIRECT – A Framework for Analyzing Network Interactions in Various...
Scientists from the University of Oklahoma and University of California at Berkeley have developed a framework iDIRECT (Inference of Direct and Indirect Relationships with...
Structure Modeling with a New Method Mapped 500 Previously Unsolved Proteins
Pathogens employ virulence factors called effectors, which are critical for their survival. Homology modeling is one of the most extensively used approaches; however, it...
The Earth BioGenome Project Steadily Started Sequencing Genomes
A worldwide endeavor to map the genomes of all life on Earth (plants, animals, fungi, and other microbes) is entering a new phase as...
Nanoantenna – The World’s Smallest Antenna Created Using DNA to Monitor...
A new DNA-based fluorescent nanoantenna is created by getting inspired by the ‘Lego-like’ properties of DNA. The building blocks of the new nanoantenna are...
Scientists Develop a Model Based on Artificial Intelligence to Predicts Risk...
The PET/CT artificial intelligence model performed better than clinical data in predicting heart attack risk in individuals with established coronary artery disease.
Predicting a heart...
Metagenomics of Human Skin Microbiome Identifies New Bacteria and Viruses
Scientists from EMBL-EBI, NIH, NHGRI, and collaborators have discovered new micro-organisms (bacterial, fungal species, and viruses) in the human skin microbiome.
The human skin microbiome...
Deep Learning Based DNA and RNA Binding Sites Prediction for Accelerated...
Targeting nucleic acid macromolecules, particularly RNA, for structure-based drug design (SBDD) is gaining research attention as it resulted in several FDA-approved compounds targeting RNA...
Multi-omics Data Visualization and Chromosomes Annotation with an R Package “ChromoMap”
ChromoMap is a fast and easy-to-use tool for visualizing genomic elements and related data (such as multi-omics data) in relation to their chromosome-by-chromosome occurrence...
Early Stage Bronchial Asthma Diagnosis with Artificial Intelligence
Scientists from Ben-Gurion University, Israel, have developed a method for computer-aided diagnostics of bronchial asthma based on machine learning. The model is trained using...
Pregnancy Health and Preeclampsia Prediction Using RNA Sequencing from a Single...
Using cell-free RNA (cfRNA), researchers discovered gene expression patterns linked to a healthy pregnancy.
Conception to birth is a fast-paced period of growth and development...
AI Driven Analysis of Cell Diversity in Drosophila melanogaster Brain
The research published in Nature combines single-cell technologies and artificial intelligence (AI) to create a new picture of gene regulation in all the fruit...
Transforming DNA-Repair Visualization by Machine Learning Coupled High-Throughput Microscopy
Machine learning may aid in repairing genetic damage and avoiding DNA mutations and chronic diseases.
Scientists from Massachusetts General Hospital and the National Cancer Research...
Evaluating gene expression in single cells with a novel computational approach...
By inventing and deploying a novel single-cell sequencing technique that potentially improves upon those already in use, researchers at the University of Chicago Medicine...
spiralize: R package to visualize data on spirals
For data visualization, the spiral arrangement offers two significant advantages. Firstly, data with long axes can be visualized, enhancing visualization resolution. Secondly, time-series data...
Antibodies that can block Omicron variant of Covid-19 identified
Antibodies have been found that neutralize Omicron and other coronavirus strains by targeting areas that stay largely unchanged as the virus mutates have been...
Cryobioprinting a technique for printing frozen and complex structures uses bioink...
A newly introduced technique takes bioprinting -; where the ink of cells does printing, layer by layer, forming a structure -; to a whole...
Predicting Gene Expression From DNA Sequence Using AI
Interpreting gene expression from the DNA sequence is one of the most challenging problems in genome biology. Decoding DNA sequence with the help of...
SARS-CoV-2 Mechanism of Evading Immune System Revealed
The mechanism used by SARS-CoV-2 to escape the host immune system has been revealed by scientists from Hokkaido University, Japan and Texas A&M University,...
Must Read
FedPyDESeq2: Advancing Differential Expression Analysis with Federated Learning for Bulk RNA-Seq
In genomics, the conventional approach for explaining any gene expression is to cross-analyze bulk RNA sequencing (RNA-seq) data. However, as researchers, more often than...
Decoding Protein Roles with ProCyon: A Unified Framework for Multiscale Phenotypes
About 20% of human proteins lack recognized functionalities, and over 40% lack context-specific functionals, underscoring the difficulties of comprehending these proteins and their varied...
Streamlining Copy Number Variation Discovery: How CNV-Finder is Changing Genomics
A prevailing challenge in genomics still revolves around the comprehension of structural variants, one of which is copy number variation (CNV). To undertake the...
Unlocking Protein Design with PLAID: A Sequence-Centric Generative Model for All-Atom Structures
The potential influence of generative models for protein design is drawing the attention of the scientific world. However, there are numerous modalities that mediate...
The Nucleotide Transformer: How Foundation Models are Shaping Human Genomics
The field of genomics is ever-changing as a result of an increase in automation and aspects of biological engineering. A groundbreaking study led by...