DANCE Unveils Hidden Depths of Protein Movement, Paving the Way for...
One must understand proteins' structural flexibility in-depth to comprehend their role in biological processes and functional systems. It is still challenging to predict various...
Beyond One-Size-Fits-All: Moffitt Unveils First Individualized Predictive Model for the Treatment...
Patients with recently diagnosed non-differentiated multiple myeloma (NDMM) have a wide range of outcomes, with overall survival (OS) spanning from several months to more...
Unlocking the Potential of RNA Design with Generative AI using GenerRNA
A team of researchers from the University of Tokyo developed GenerRNA, the first large-scale pre-trained AI model for automated RNA design that does not...
GPCR-BERT: Revolutionizing GPCR Research with Protein Language Models
Recent advances in large language models (LLMs) and transformers have opened new possibilities for modeling protein sequences as language. Carnegie Mellon University researchers have...
tFold Unveiled: A Swift and Accurate Approach to Antibody-Antigen Complex Modeling...
The soldiers of our immune system, antibodies, bind to specific targets like viruses and toxins and neutralize them. Predicting antibody-antigen complex structures accurately has...
Choosing the Best Tool for Identifying Transcriptional Regulators: Navigating the NGS...
This article delves into a recent study undertaken by a team of researchers that examined multiple computer algorithms for transcriptional regulator prediction using Next-Generation...
Unveiling the Power of Deep Learning: A Comprehensive Benchmark of Tertiary...
Before understanding RNA biology, one must grasp the three-dimensional structure of RNA. Because experimental procedures require a lot of labor and money, computer approaches...
Making AI-Driven Structural Biology Accessible with Foldy
Recent breakthroughs in AI-based protein structure prediction have enormous potential to accelerate discoveries across the life sciences. However, major barriers persist in making these...
MarkerGeneBERT: Revolutionizing Cell Marker Extraction Utilizing Natural Language Processing
MarkerGeneBERT, a natural language processing (NLP) system to automatically extract cell type markers from single-cell sequencing literature by parsing full text, was recently introduced...
CombFold: Advancing Structure Prediction of Large Protein Assemblies with Combinatorial Algorithms...
Deep learning models like RosettaFold and AlphaFold2 can predict protein structure with high accuracy; however, they still have difficulties when it comes to intricate...
Unleashing nanoBERT: Revolutionizing Nanobody Therapeutics with Deep Learning
Scientists from the University of Southern Denmark, NaturalAntibody and Alector Therapeutics unveil nanoBERT, a nanobody-specific transformer designed to predict amino acids in specific positions...
UChicago Scientists Crack the Code of HIV Entry into the Nucleus...
In a major scientific breakthrough, researchers at the University of Chicago have succeeded in creating a comprehensive model of the nuclear pore complex with...
reguloGPT Unleashed: GPT-Powered Knowledge Graphs Illuminate Molecular Regulatory Pathways
Understanding biological processes and offering organized representations of intricate relationships are made possible by Knowledge Graphs, or KGs. However, the resources available today to...
Has ESM-2 Truly Learned the Language of Protein Folding?
Protein structure prediction and design may be accomplished using protein language models (pLMs). They may not completely comprehend the biophysics of protein structures, though....
Revolutionize RNA Structure Prediction with RNA3DB: The Pinnacle Dataset for Training...
Harvard University researchers introduce RNA3DB, a dataset crafted from the Protein Data Bank (PDB), addressing challenges in RNA structure prediction. In response to limitations...
Revolutionizing Protein-protein Interaction Prediction with LazyAF: A Breakthrough Pipeline for Medium-scale...
Predicting protein structures has been transformed by artificial intelligence. However, rather than competence, accessibility, and ease of use are increasingly becoming limiting issues for...
Unlocking the Enhancer Code: Deep Learning’s Role in Designing Cell-specific Genetic...
Transcriptional enhancers control the spatiotemporal activation of the target genes they regulate by serving as docking stations for various transcription factor combinations. It has...
Probing Ancestral Genomes Uncovers Unannotated Degenerate Transposable Elements Contributing to Gene...
Transposable elements (TEs) supply genomes with both coding and non-coding sequences and have significant roles in evolution. However, the extent of TE annotations in...
Meet IntegrAO: A Novel Unsupervised Framework for Integrating Incomplete Multi-omics Data...
Advances in high-throughput omics profiling have improved cancer patient classification significantly. However, insufficient data in multi-omics integration is a big problem because conventional techniques...
Unlocking Cellular Mysteries with scPerturb: A Deep Dive into Harmonized Single-cell...
Molecular and phenotypic responses to numerous perturbations are revealed by the increasing number of single-cell perturbation studies. However, variations in format, naming conventions, and...
PepHarmony: An Integrated Sequence and Structure-based Peptide Encoding Framework Employing Multi-view...
Gaining insight into the relationship of the Peptide sequence (the amino acid sequence) and their structure (the way they fold and interact) is a...
Empowering Researchers with ProteomicsML: An Online Oasis of Data Sets and...
The laborious aspects of acquiring and curating data sets for machine learning, especially in proteomics-based systems, present unique difficulties because there is a significant...
The Human Immunome Project: Mapping the Global Landscape of Immune Diversity...
In a landmark initiative, the Human Immunome Project (HIP) commenced at a summit in La Jolla, California, bringing immunology specialists together to address the...
Unveiling ProtHyena: A Fast and Efficient Protein Language Model for Analysis...
The field of biological sequence analysis has lately benefited from the revolutionary changes brought about by the development of self-supervised deep language models for...
IntelliGenes Unveiled: A New Paradigm for AI-Driven Biomarker Discovery from Multi-genomic...
IntelliGenes is a new machine learning pipeline developed by researchers at The State University of New Jersey that integrates multi-genomics, clinical, and demographic data...
Meet Lingo3DMol: A Pocket-based 3D Molecule Generation Method Leveraging Language Models...
The drug development process involves a winding trail across the enormous chemical wilderness, looking for compounds that interact ideally with their target proteins. Traditional...
Unveiling the Future of Protein Design: RFdiffusion’s De Novo Revolution
Protein design has seen significant progress, but a comprehensive deep-learning framework for protein design, including de novo binder design and higher-order symmetric architectures, remains...
Cleveland Clinic and IBM’s Blueprint for Discovering Novel Immunotherapy Targets Using...
Predicting the immunogenicity of peptide antigens attached to major histocompatibility complex (MHC) molecules is critical for developing new immunotherapies and better understanding human immune...
Transforming Protein Engineering with UW-Madison’s Self-Driving Labs ‘SAMPLE’: A Cutting-edge, AI-driven...
Although the field of protein engineering offers countless applications in chemistry, energy, and medicine, the process of designing new proteins with enhanced or unique...
Meet ChatDrug: A New ChatGPT-powered Conversational Drug Editing Framework
Drug discovery is one of the many fields where recent developments in conversational large language models (LLMs), like ChatGPT, have shown incredible promise. However,...
MIT Introduces PRISM: Advancing Early Detection of Lethal Pancreatic Cancer with...
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive cancer with a poor prognosis, owing mostly to late diagnosis. Expanding screening beyond the 10% now...
Unlocking Brain Mysteries with BrainLM: A Versatile Foundation Model for Recording...
The Brain Language Model (BrainLM), a foundation model for brain activity dynamics trained on 6,700 hours of functional magnetic resonance imaging (fMRI) scans, was...
MIT’s Noninvasive Technique “Raman2RNA” Reveals Cells’ Gene Expression Dynamics Over Time
Understanding cell dynamics, regulation, and characteristics has been revolutionized by profiling tests at a previously unheard-of resolution. Nevertheless, the destructive nature of these techniques...
The Glue that Heals: St. Jude’s Researchers Unveil Molecular ‘Super-Glue’ Propelling...
Scientists at St. Jude Children's Research Hospital have published their findings on SJ3149, a chemical with broad efficacy against various cancer types, particularly acute...
Fighting Pathogens Smarter: How Machine Learning and Data Integration Improves Bacterial...
CRISPR interference (CRISPRi) is one of the most widely used CRISPR technologies in bacteria. In this, a catalytically dead Cas protein incapable of DNA...
Mapping Cancer’s Weaknesses: A Comprehensive Map of Cancer Cell Dependencies Accelerates...
Cancer, a simple name for a complicated group of diseases, has long perplexed scientists and healthcare professionals alike. Despite years of research and medical...
Language Models Paired with Geometric Deep Learning Revolutionize Genome-scale Protein Binding...
Protein structures depend on nucleic acids and tiny ligands to establish binding sites. Accurate identification of these locations is necessary due to the exponential...
Integrating Genomic and Clinical Data from the 100,000 Genomes Cancer Program...
In order to establish standardized high-throughput whole-genome sequencing (WGS) for patients with cancer and rare diseases, the UK Government launched the groundbreaking 100,000 Genomes...
Illuminating AMBERff’s Potential: AMBER Force Fields Meet NAMD in Multimillion-Atom Simulations
AMBERff with NAMD is implemented by researchers from the University of Delaware to enable simulations of large systems built upon existing software infrastructure. Increasingly...
High-throughput ADMET Properties Prediction Made Easy with ADMET-AI: A New Platform...
A vital step in drug discovery is accurately evaluating potential drug candidates' Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET). Traditionally, this process has been...
New Principles Underlying Neural Activity Discovered With Startling Implications For Machine...
One of the biggest challenges in the machine learning space today is the problem of credit assignment: the identification of the components within the...
BaseMEMOIR: Breakthrough in Cell Lineage Tracing with Image-readable Base Editor Recording
For decades, tracing the lineage of individual cells has been a difficult and unreliable task. Existing methods like dye labeling and genetic barcoding have...
Scripps Scientists Develop High-Resolution Method to Uncover Druggable Sites on Proteins
The factors at play in the binding of proteins are intricate and hard to untangle - despite great advancements in recent years in humanity’s...
Cracking the Code of Complex Diseases: Utilizing FORGEdb to Identify Functional...
A majority of variations linked to disease that have been found by genome-wide association studies are not found in areas that code for proteins....
From PCA to PCA-Plus: Advancing Principal Component Analysis for More Robust...
PCA (Principle Component Analysis) is a commonly used technique in biomedical research to identify similarities and differences between groups of samples. Though conventional PCA...
Mount Sinai Researchers Introduce mEnrich-seq: A New Approach to Enriching Taxa...
In this study, researchers at Icahn School of Medicine developed mEnrich-seq, a method that can enrich taxa of interest from metagenomic DNA before sequencing....
Alexa, Analyze Cancer Data: Meet Melvin, Your Virtual Genomics Assistant
Researchers at the University of Singapore introduced "Melvin," an Alexa Skill that lets you query cancer genomics data with your voice. This groundbreaking tool...
Breaking Barriers in Genomic Research: DRAGEN Delivers Accurate Variant Detection in...
Scientists took decades to decode the complex code of DNA, and though we have come a long way, the journey is far from over....
Exploring the Diversity of Scavenger Receptor Class B Proteins Across Eukarya:...
The class B scavenger receptor (SR-B) proteins, which are essential for innate immunity, pathogen identification, apoptotic cell clearance, and metabolic sensing, have an ectodomain...
AlphaFold’s Latest Strides: Improved Accuracy for Antibody-Antigen Complex Modeling
The launch of AlphaFold signaled a revolution in computational modeling: armed with new knowledge of protein structures and unencumbered by limitations on resources and...
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How Does NeuralPLexer3 Combine Physics and Machine Learning for Superior Biomolecular Predictions?
The quest to understand biomolecular interactions is central to advancing drug discovery, molecular biology, and bioengineering. A significant step in this journey is accurately...
FedPyDESeq2: Advancing Differential Expression Analysis with Federated Learning for Bulk RNA-Seq
In genomics, the conventional approach for explaining any gene expression is to cross-analyze bulk RNA sequencing (RNA-seq) data. However, as researchers, more often than...
Decoding Protein Roles with ProCyon: A Unified Framework for Multiscale Phenotypes
About 20% of human proteins lack recognized functionalities, and over 40% lack context-specific functionals, underscoring the difficulties of comprehending these proteins and their varied...
Streamlining Copy Number Variation Discovery: How CNV-Finder is Changing Genomics
A prevailing challenge in genomics still revolves around the comprehension of structural variants, one of which is copy number variation (CNV). To undertake the...
Unlocking Protein Design with PLAID: A Sequence-Centric Generative Model for All-Atom Structures
The potential influence of generative models for protein design is drawing the attention of the scientific world. However, there are numerous modalities that mediate...