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DGNN-DDI: A Cutting-edge Tool for Drug-Drug Interaction Prediction using Dual Graph Neural Network

DGNN-DDI: A Cutting-edge Tool for Drug-Drug Interaction Prediction using Dual Graph...

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Scientists from Shaanxi Normal University, China, developed a novel Drug-Drug-Interactions (DDI) prediction tool that implements a dual graph neural network architecture to incorporate chemical...
Connection Between Immune Response & Persistent Smell Loss Post-COVID-19

New Study Finds Connection Between Immune Response & Persistent Smell Loss...

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Most SARS-CoV-2 patients experience anosmia, or a loss of smell, which can linger for months after recovery. According to olfactory epithelium samples taken from...
ZFDesign: A Universal Deep Learning Model for Zinc Finger Design Enabling Transcription Factor Reprogramming

Meet ZFDesign: A Universal Deep Learning Model for Zinc Finger Design...

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Controlling gene expression by engineering Cys2His2 zinc finger (ZF) domains to bind particular target sequences in the genome has many therapeutic applications. However, due...
A Tabular Machine Learning Approach to Pan-cancer Tumor-only Variant Calling

Machine Learning in Oncology: A Tabular Machine Learning Approach to Pan-cancer...

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Accurately identifying somatic mutations and differentiating them from germline variations is critical for precision oncology and precise tumor-mutational burden (TMB) computation. For this purpose,...
De novo protein generation with conditional language model ProGen

AI Proteins: Unlocking the Potential of Protein Generation from Scratch with...

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Scientists from the University of California, San Francisco, have created an inventive AI system that can create entirely new enzymes from scratch. Even though...
Navigating the choice of informatics software and tools for lipidomics research. Providing a Lipidomics Tools Guide on LIPID MAPS.

Luminary for Lipidomics Research Applications: Guiding the Choice of Informatics Software...

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There has been an increase in research in numerous areas of biology and medicine due to the development of mass spectrometry lipidomics. As a...
De Novo Drug Design Using Generative Deep Learning: The Role of Chemical Language Models with Molecular Structures and Bioactivity

De Novo Drug Design Using Generative Deep Learning: Implementing Chemical Language...

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Chemical language models (CLMs) can be used to construct molecules with desired features. Textual representations of novel chemical structures, such as simplified molecular input...
protein structure and function characterization

ML meets Structural Bioinformatics: Novel Machine Learning Approaches Transforming Protein Research...

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Scientists from University College London, UK, study the Machine Learning (ML) approaches that have successfully closed the ever-widening gap between large amounts of protein...
Drug-Targeted Genome Interactions with a New DNA Sequencing Method Chem-map

Discovering the Secrets of Drug-Targeted Genome Interactions with a New DNA...

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Scientists from the University of Cambridge have introduced a cutting-edge DNA sequencing method that can precisely pinpoint the location and mechanism of small molecule...
Understanding of Viruses with Complete Reconstruction

Aston University Paves the Way for New Understanding of Viruses with...

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Aston University scientists have made a groundbreaking discovery in the field of virology. They were able to create a 3D model of the virus...
Espresso

Meet “Espresso”: The Solution for Accurate Quantification of Transcript Isoforms in...

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The Children's Hospital of Philadelphia (CHOP) scientists have created ESPRESSO, a new computational tool for analyzing RNA-seq data. ESPRESSO aims to improve the detection...
Federated Learning Deployed Across Hospitals to Train Deep Learning Models Securely

Revolutionizing Healthcare: Federated Learning Deployed Across Hospitals to Train Deep Learning...

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Owkin, an AI biotech company, has successfully used federated learning (FL) for the first time to train deep learning models on histopathology data from...
Deep Learning and Radiomics: A Game-Changer for Identifying Glioblastoma and Brain Metastasis

Deep Learning and Radiomics: A Game-changer for Identifying Glioblastoma and Brain...

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According to a recent study from Karl Landsteiner University of Health Sciences (KL Krems), using radiomics and deep learning algorithms can quickly and accurately...
ImageMol – A Powerful Self-supervised Image Representation Learning Framework for Accurate Prediction of Molecular Properties and Drug Targets

ImageMol – A Powerful Self-supervised Image Representation Learning Framework for Accurate...

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Scientists from Case Western Reserve University, Cleveland, USA, developed a self-supervised image representation learning framework, "ImageMol," for predicting molecular properties and drug targets with...
BioNTech's Acquisition of InstaDeep Set to Revolutionize AI-Powered Drug Discovery, Design, and Development

BioNTech’s Acquisition of InstaDeep Set to Revolutionize AI-Powered Drug Discovery, Design,...

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BioNTech, a leading biopharmaceutical company, has announced plans to fully acquire InstaDeep, an artificial intelligence company specializing in drug discovery, design, and development. This...
Phosphorylation-site motif tree of the human Ser/Thr kinome

Discovering the Secrets of the Human Kinome: An Atlas of Substrate...

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Researchers from MIT have created a comprehensive map of over 300 protein kinases and their targets, with the goal of potentially discovering new cancer...
Lung Cancer's Immune Evasion Tactics

Uncovering Lung Cancer’s Immune Evasion Tactics: Groundbreaking Study Sheds Light on...

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Lung cancer is one of the most common and deadly types of cancer worldwide, and the ability of cancer cells to evade the body's immune system poses a significant challenge in treating it. A team of Weill Cornell Medicine scientists recently made a significant breakthrough in understanding this process. They discovered a genetic signature that can predict patient survival and identified a key mechanism lung cancer cells use to avoid immune attacks. This groundbreaking discovery could hasten the development of treatments that can circumvent tumor defense mechanisms, increasing the chances of survival for lung cancer patients. The signaling pathway involving IRE1 and XBP1 is becoming increasingly recognized as a key player in cancer progression and immune system suppression in various...
SPICEMIX: A Machine Learning Approach for Improved Cell Identity Understanding

Meet SPICEMIX: A Machine Learning Approach for Improved Cell Identity Understanding

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Scientists from Carnegie Mellon University developed SPICEMIX, a machine learning method that allows researchers to better understand the contribution of various spatial patterns to...
Digital Twins Unlock the Key to New Biomarker Discovery for Atherosclerosis

Digital Twins Unlock the Key to New Biomarker Discovery for Atherosclerosis

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A recent study utilized digital twin technology to identify new markers for atherosclerotic coronary artery disease (ASCAD). The study was conducted by G3 Therapeutics,...
Predicting Drug Success: The Role of Computer Models in Determining Drug's Binding Affinity to Proteins

Predicting Drug Success: The Role of Computer Models in Determining Drug’s...

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When it comes to developing new drugs, one of the most important considerations is how well a candidate drug will bind to its target...
The Human Protein Atlas: Database Maps Proteins that could Predict Cancer Types

Revolutionizing Cancer Detection: A New Database Maps Proteins that could Predict...

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The ability to predict cancer has advanced with the recent release of a new database that includes information on cancer proteins and was developed...
Speeding Up Drug Design & Development: Harnessing the Power of Machine Learning

Speeding Up Drug Formulation Development: Harnessing the Power of Machine Learning

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Scientists at the University of Toronto advanced drug formulation development by utilizing machine learning techniques to predict and guide the design of long-acting injectable...
CHESSBOARD: A Bayesian Approach to Identifying Cancer Subtypes through Unsupervised Detection of RNA Splicing

CHESSBOARD: A Bayesian Approach to Identifying Cancer Subtypes through Unsupervised Detection...

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Finding cancer subtypes is a crucial first step in creating individualized care. In particular, RNA splicing change-based sub-typing has been encouraged by a number...
Unraveling the Mechanics of DNA: Scientists Decrypt the 'Mechanical Code'

Unraveling the Mechanics of DNA: Scientists Decrypt the ‘Mechanical Code’

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The mechanical properties of DNA are affected by various processes, including local sequence and epigenetic modifications. It has been challenging to understand the relationship...
Genomics and Phenomics of Body Mass Index Reveals a Complex Disease Network

Exploring the Intersection of Genomics and Phenomics in the Study of...

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The relationship between Body Mass Index (BMI) and several health issues that have an influence on morbidity and mortality has been the focus of...
Regulatory Genomics Toolbox (RGT): A Toolbox for Analyzing High Throughput Regulatory Genomics Data

Discover the Power of RGT: A Toolbox for Analyzing High Throughput...

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The Bioinformatics and Genomics Group at the University of Barcelona has developed "RGT" (Regulatory Genomics Toolbox), a powerful tool for the integrative analysis of...
The structure of DNA polymerase theta

Scientists Discover How DNA Repair Enzyme ‘DNA polymerase θ’ Could Revolutionize...

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DNA polymerase θ is an enzyme that plays a crucial role in the process of repairing broken strands of DNA. In a recent study,...
What are biomolecules?

What are Biomolecules?

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Biomolecules are molecules produced by living organisms and are essential for the proper functioning of an organism's cells and tissues. They include molecules such...
Exploring Type 2 Diabetes Drug-Omics Associations Using Deep Learning Models

Exploring Type 2 Diabetes Drug-Omics Associations Using Deep Learning Models

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Multiple omics technologies may be used in biological cohorts to identify patient-level disease features and unique treatment responses. The size and heterogeneity of the...
DeepMosaic: A Computer Program that 'Learns' to Identify Mosaic Mutations Causing Disease

Meet DeepMosaic: A Computer Program that ‘Learns’ to Identify Mosaic Mutations...

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Scientists from the University of California San Diego School of Medicine and Rady Children's Institute for Genomic Medicine have developed a method "DeepMosaic" for...
A Hidden Markov Modeling Approach for Estimating Orientations and Structures of Biomolecules from High-Speed Atomic Force Microscopy Time-Series Images

A Hidden Markov Modeling Approach for Estimating Orientations and Structures of...

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Saitama University, Japan, researchers developed a powerful method for observing the time-resolved behavior of biomolecules through high-speed atomic force microscopy (HS-AFM), thus improving the...
OpenGenomeBrowser: A Versatile, Scalable, and Dataset-Independent Web Platform for Comparative Genomics

Exploring the Genome with OpenGenomeBrowser: A Versatile, Scalable, and Dataset-Independent Web...

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The OpenGenomeBrowser, developed by researchers from the University of Bern, is a web platform that allows researchers to manage and analyze microbial genome data,...
GCNCPR-ACPs: Predicting Anticancer Peptides based on Graph Convolution Network

Meet GCNCPR-ACPs: An Innovative Model for Predicting Anticancer Peptides Based on...

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Researchers at the School of Informatics, Xiamen University, China, and Computational Health Informatics Program, Boston Children’s Hospital, USA developed the GCNCPR-ACPs method to effectively...
What is RNA? Difference DNA and RNA

What is RNA?

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RNA (ribonucleic acid) is a molecule that plays a variety of important roles in the body. It is a single-stranded nucleic acid that is...
BioNumPy: A Powerful Tool for Quick and Easy Biological Data Analysis with Python

Meet “BioNumPy”: A Powerful Tool for Quick and Easy Biological Data...

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Scientists from the University of Oslo, Norway, presented a brand-new Python module called BioNumPy that builds a layer on top of NumPy to make it...
OpenAI's GPT-3: A Promising AI Tool for Early Detection of Alzheimer's Disease

OpenAI’s ChatGPT: A Promising AI Tool for Early Detection of Alzheimer’s...

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Researchers at Drexel University's School of Biomedical Engineering, Science, and Health Systems have found that ChatGPT, an AI-powered chatbot program, may be able to...
The procedures of ATGO for protein function prediction.

Unleashing the Power of Unsupervised Language Model and Triplet Neural Network...

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To understand how living systems operate and develop new medications, it is essential to identify protein functions accurately. Researchers from the USA propose a...
MACHINE LEARNING MODEL TO DECIPHER THE MICROENVIRONMENTAL COMMUNICATION NETWORKS OF INDIVIDUAL TUMORS

Scientists Design Machine Learning Model to Decipher the Microenvironment Communication Networks...

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Intercellular networks between key players in the tumor microenvironments make tumor cells invincible against the body’s natural defense mechanisms. Identifying and targeting these interactions...
Top 10 Bioinformatics Breakthroughs of 2022!

Top 10 Bioinformatics Breakthroughs of 2022!

The field of bioinformatics has seen numerous exciting breakthroughs in the year 2022 that have transformed the landscape of biological research. Many important discoveries...
What is DNA?

What is DNA?

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Welcome to this informative article on DNA. Let's see what is DNA? DNA stands for deoxyribonucleic acid, and it is a long, spiral-shaped molecule...
Identify Plasmodium vivax Malaria Using Molecular Barcoding and Web-Based Data Analysis

Identifying Imported Plasmodium vivax Malaria Using Molecular Barcoding and Web-Based Data...

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Researchers from Indonesia and Australia have developed a molecular barcode and a web-based data analysis tool to identify and track imported cases of Plasmodium...
Combination Therapy: Engineered Bacterial Therapeutics and Traditional Cancer Treatments for Improved Lung Cancer Outcomes

Exploring the Potential of Combination Therapy: Utilizing Engineered Bacterial Therapeutics and...

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According to researchers at Columbia Engineering, they have developed a preclinical evaluation pipeline for assessing the effectiveness of bacterial therapies in lung cancer models....
Artificial Intelligence I Powered Dementia Detection: A Digital Solution for Identifying Undiagnosed Cases

AI-Powered Dementia Detection: A Digital Solution for Identifying Undiagnosed Cases

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Scientists from the Regenstrief Institute, IUPUI, Indiana University, and the University of Miami are using Artificial Intelligence to identify undiagnosed cases of dementia in...
3D Bioprinting Takes Eye Tissue Engineering to New Heights at NIH

3D Bioprinting Takes Eye Tissue Engineering to New Heights at NIH

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Scientists at the National Eye Institute (NEI), part of the National Institutes of Health, have made a significant advancement in the field of 3D...
LC-MS2Struct: Machine Learning Model Decoded the World of Small Molecules.

Scientists Harnessed the Power of Machine Learning to Decode the World...

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Scientists from Aalto University and the University of Luxembourg have developed a machine learning model that can accurately identify small molecules. The model has...
Understanding the signals that plants use to initiate the process of photosynthesis.

Unveiling the Hidden Messages of Photosynthesis: Deciphering the Language of Plant...

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Researchers at UC Riverside have made a breakthrough in understanding the signals that plants use to initiate photosynthesis, the process of converting sunlight into...
tFold-Ab predicts the structure of antibodies and nanobodies

tFold-Ab: A Novel Antibody Structure Prediction Method without Sequence Homologs

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Antibodies are crucial components of the immune system, and their structure is critical for their function. Predicting the three-dimensional structure of antibodies without the...
MACHINE LEARNING FOR BIOMARKER DISCOVERY USING NGS DATA

MACHINE LEARNING FOR BIOMARKER DISCOVERY USING NGS DATA

In this article, we will be exploring how machine learning (ML) techniques can be used to identify and analyze biomarkers from next generation sequencing...
Bioinformatics Approaches used in Single-cell Technologies: Recent Progress and Future Directions in Applied Research

Bioinformatics Approaches used in Single-cell Technologies: Recent Progress and Future Directions...

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Researchers from China examined the experimental and bioinformatics approaches used in single-cell research as well as their applications in a variety of industries, thereby...
Annotate_my_genomes: A Simple Pipeline for Improved Genome Annotation and Neglected Gene Discovery through Hybrid RNA Sequencing

Annotate_My_Genomes: A Simple Pipeline for Improved Genome Annotation and Neglected Gene...

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A simple genome-guided transcriptome annotation pipeline created by researchers from Chile and the University of Manitoba in Winnipeg, Manitoba, Canada, that takes compiled transcripts...

Must Read

AI Function Prediction

Solving a Long-Standing Genomics Bottleneck: KAIST Proposes AI-Powered Strategy for Gene Function Prediction

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KAIST and UCSD researchers proposed AI-driven strategies for microbial gene function discovery, addressing the long-standing bottleneck where many microbial genes remain uncharacterized despite advances...
MetagenBERT

AI-Powered Metagenomics: How MetagenBERT Predicts Disease From Raw DNA Sequences

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Researchers from Sorbonne University and Dauphine University, France, introduced MetagenBERT, a Transformer-based framework for disease prediction directly from raw metagenomic DNA without relying on...
Topos-1

ToposBio Unveils Topos-1: An All-Atom Foundation Model for Intrinsically Disordered Proteins

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Intrinsically disordered proteins (IDPs) are proteins that are central to neurodegenerative diseases and aggressive cancers like prostate cancer, have been considered ‘undruggable’ as structures...
CleaveNet

CleaveNet Enables Scalable and Targeted Protease Substrate Design for Diagnostics and Therapeutics

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Scientists from MIT and Microsoft Research present CleaveNet, an AI-based pipeline that merges predictive and generative modeling for end-to-end peptide (short protein) design. By...
PeptiVerse

Advancing Peptide Therapeutics with PeptiVerse’s Unified Prediction Framework

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Researchers at the University of Pennsylvania developed PeptiVerse, a single platform that predicts drug-related properties of therapeutic peptides using either amino acid sequences or...