Genomics

Bioinformatics | Gene Expression | Genomics | News | Paper Summary | Sequencing | Trending

Did Aquatic Algae Pave the Way for Lush Forests? New Research Suggests Yes!
ByAnchal Negi May 8, 2024October 22, 2026

Have you ever wondered how those dense jungles and tall trees appear? It began with a leap from the water, a colonization attempt by our plant forebears more than 550 million years ago. But how could these marine organisms have acquired the necessary adaptations for living in such an arid environment? — A recent publication…

Read More Did Aquatic Algae Pave the Way for Lush Forests? New Research Suggests Yes!
Bioinformatics | Machine Learning | News | Paper Summary | RNA-Seq | Sequencing | Tools | Trending

Deciphering the Future with Decipher: A Computational Pipeline for Single-cell Profile-based Context-specific Mechanistic Insights
ByDeotima Chakraborty May 8, 2024October 22, 2026

The development of single-cell profiling methods has transformed our understanding of the cellular and molecular processes underlying disease states and how they respond to therapy. However, existing computer methods cannot objectively recover known and new mechanistic insights at different levels of biological regulation. Here, researchers from the University of Western Australia and The University of…

Read More Deciphering the Future with Decipher: A Computational Pipeline for Single-cell Profile-based Context-specific Mechanistic Insights
AI | Bioinformatics | Genomics | News | OMICS | Paper Summary | Tools | Trending

DeepGene: Revolutionizing Genomics with Pan-genome Graph Transformer-based Foundation Model
ByDeotima Chakraborty May 4, 2024October 22, 2026

A significant issue in genome research is the Nucleotide Transformer, which makes DNA sequence interpretation accurate only with models such as DNABERT-2. Although these models have made great strides in a number of DNA analysis tasks, issues with genetic language variety, model efficiency, and length extrapolation remain. The objective is to improve performance at costs…

Read More DeepGene: Revolutionizing Genomics with Pan-genome Graph Transformer-based Foundation Model
AI | Bioinformatics | Gene Expression | Genomics | News | Paper Summary | Trending

From Genome to Function: AI Predicts Gene Regulation in Newly Sequenced Plants
ByAnshika Gupta May 3, 2024October 22, 2026

A recent study published in Nature Communications explored the relationship between gene expression prediction and the use of deep learning models, which are the most advanced models or architectures in the domain of machine learning. Fritz Forbang Peleke and Jędrzej Szymański head the group to uncover the role of non-coding regulatory elements in gene expression…

Read More From Genome to Function: AI Predicts Gene Regulation in Newly Sequenced Plants
AI | Big Data | Bioinformatics | Computational Models | Gene Expression | Genomics | Machine Learning | News | OMICS | Paper Summary | RNA-Seq | Tools | Trending

Decoding the Regulatory Landscape with LINGER: A New Era in Gene Regulatory Networks Inference
ByDeotima Chakraborty April 27, 2024October 22, 2026

Despite the difficulties presented by the current methods depending solely on gene expression data, RNA sequencing data has been incorporated into Gene regulatory networks (GRN) inference methods, improving the capacity to learn complicated pathways from a few independent data points. Here, scientists offer LINGER (Lifelong neural network for gene regulation), a machine-learning technique that uses…

Read More Decoding the Regulatory Landscape with LINGER: A New Era in Gene Regulatory Networks Inference
Bioinformatics | Genomics | GWAS | News | OMICS | Paper Summary | Trending

Unlocking the Genetic Basis of PTSD: Discovery of 95 Loci Reveal Neurobiological Underpinnings of Trauma and Stress
ByDeotima Chakraborty April 26, 2024October 22, 2026

When compared to other mental conditions, posttraumatic stress disorder (PTSD) has a lower discoverability rate. A meta-analysis encompassing many ancestries, including European, African, and Native American, revealed 95 relevant sites across the genome and 43 putative causative genes. These genes are categorized as developmental factors, immunological or endocrine regulators, neurotransmitter and ion channel synaptic modulators,…

Read More Unlocking the Genetic Basis of PTSD: Discovery of 95 Loci Reveal Neurobiological Underpinnings of Trauma and Stress
Bioinformatics | Genomics | News | Trending

The Molecule That Changed Everything: The Story of DNA
ByAnshika Gupta April 25, 2024October 22, 2026

One of the greatest scientific discoveries in history is the double helix structure of DNA, which was discovered by James Watson and Francis Crick in 1953. This groundbreaking discovery fundamentally changed our knowledge of genetics and set the stage for several scientific breakthroughs. As we celebrate DNA Day, let us reflect on this important milestone…

Read More The Molecule That Changed Everything: The Story of DNA
Bioinformatics | Genomics | News | Paper Summary | Trending | Virus

Deciphering the Genetic Blueprint: Groundbreaking Research Reveals Genomic Factors Driving Monkeypox Virus Transmissibility
ByAnshika Gupta April 24, 2024October 22, 2026

An epidemic of monkeypox occurred in May 2023 that led to a disease named mpox displaying symptoms such as fever, enlarged lymph nodes, and rash. This ailment is usually mild and self-limited, but severe cases can be harrowing and may cause lifetime scarring. In response to the outbreak, researchers from Mount Sinai and the Carlos…

Read More Deciphering the Genetic Blueprint: Groundbreaking Research Reveals Genomic Factors Driving Monkeypox Virus Transmissibility
AI | Bioinformatics | Genomics | LLM | News | Paper Summary | Tools | Trending

Unlocking Protein Co-regulation: How Genomic Language Models Illuminate Function Predictions
ByAnshika Gupta April 21, 2024October 22, 2026

Are you aware of the perception of a genomic language model? If not, then it’s worth mentioning that researchers at Harvard, Cornell University, and the Massachusetts Institute of Technology developed gLM, a Genomic Language Model, which is trained on enormous amounts of metagenomic data to interpret gene contextual representations. Using pLM embeddings and transformer architecture,…

Read More Unlocking Protein Co-regulation: How Genomic Language Models Illuminate Function Predictions
Big Data | Bioinformatics | Cancer | Cloud Computing | Epigenomics | News | NGS | Paper Summary | Sequencing | Tools | Trending

Supercharge Epigenomic Workflows with EAP: A Cloud-Based Platform for Comprehensive and Interactive Analysis of Large ChIP/ATAC-seq Datasets
ByDeotima Chakraborty April 15, 2024October 22, 2026

The significance of comprehending gene expression regulation in tissue development is highlighted by the examination of disease progression through methods such as ChIP-seq and ATAC-seq. On the other hand, the growing volume of data poses computing difficulties, and the dearth of organized tools emphasizes the requirement for effective analysis platforms. Researchers from the Shanghai Institute…

Read More Supercharge Epigenomic Workflows with EAP: A Cloud-Based Platform for Comprehensive and Interactive Analysis of Large ChIP/ATAC-seq Datasets
AI | Bioinformatics | Cell | Genomics | LLM | News | Paper Summary | Trending

Unlocking Cell Biology with AI: How Large Language Models Comprehend the Complexity of Genes and Cells
ByAnchal Negi April 14, 2024October 22, 2026

Picture a world where computers can not only translate languages but also decipher biology’s convoluted language. This is the exciting frontier of Large Language Models (LLMs) that could transform our knowledge of genes and cells, which are the foundation of all life forms. Researchers from the Center, Chinese Academy of Sciences, China, explore this intriguing…

Read More Unlocking Cell Biology with AI: How Large Language Models Comprehend the Complexity of Genes and Cells
Bioinformatics | Database | Genomics | News | Paper Summary | Trending

Unlocking the Microbial Universe: AllTheBacteria – Unparalleled Resource for Bacterial Genomics
ByDeotima Chakraborty March 15, 2024October 22, 2026

DNA archives are a public repository for a great amount of knowledge about the evolution of bacteria and their mobile elements. However, the majority of this data is not well-constructed or is assembled inconsistently, which renders it inappropriate for extensive analysis. A consistently assembled set of 661,405 genomes was released by Blackwell et al. in…

Read More Unlocking the Microbial Universe: AllTheBacteria – Unparalleled Resource for Bacterial Genomics
AI | Bioinformatics | Genomics | LLM | News | Paper Summary | Trending

From Molecules to Genomes: Evo’s Trailblazing Approach to Sequence Modeling and Design
ByDeotima Chakraborty March 1, 2024October 22, 2026

The DNA, RNA, and proteins that control an organism’s entire functioning are all fully encoded in a sequence called the genome. Large-scale genome databases and machine learning advances may make it possible to create a biological foundation model that speeds up the generative design and mechanistic analysis of intricate molecular interactions. Researchers from Arc Institute, TogtherAI, and…

Read More From Molecules to Genomes: Evo’s Trailblazing Approach to Sequence Modeling and Design
Bioinformatics | Database | Genomics | GWAS | News | NGS | Paper Summary | Precision Medicine | Trending

NIH’s All of Us Research Program Unveils 275 Million New Genetic Variants, Boosting Precision Medicine Efforts
ByAnchal Negi February 23, 2024October 22, 2026

The All of Us Research Program, with its ambitious objective of creating a diverse cohort of one million volunteers and making their data available for research, has enormous potential for revealing new information about human health and illness. Researchers have discovered more than 275 million previously unreported genetic variants, identified from data shared by nearly…

Read More NIH’s All of Us Research Program Unveils 275 Million New Genetic Variants, Boosting Precision Medicine Efforts
AI | Bioinformatics | Chemoinformatics | Computational Models | Drug Discovery | LLM | News | Paper Summary | Trending

Revolutionizing Drug Discovery with ChemGLaM: Chemical-Genomics Language Models for Compound-Protein Interaction Prediction
ByDeotima Chakraborty February 21, 2024October 22, 2026

Compound-protein interaction (CPI) prediction accuracy is crucial for drug discovery. Creating deep learning models that can be applied broadly requires expanding the CPI data through experimental validation. With their strong generalization performance in a range of tasks involving substances and proteins, large language models (LLMs) such as chemical and protein language models have become foundational…

Read More Revolutionizing Drug Discovery with ChemGLaM: Chemical-Genomics Language Models for Compound-Protein Interaction Prediction
AI | Bioinformatics | Genomics | LLM | News | OMICS | Paper Summary

Meet DNABERT-S: Illuminating Genomic Diversity through Species-Aware DNA Embeddings
ByAnchal Negi February 18, 2024October 22, 2026

For scientists studying the functions of the genome, DNA embedding is a vital tool. Effective investigations like species categorization and metagenomics binning are made possible by converting unprocessed DNA sequences into comprehensible numerical representations. Modern embedding models, however, often require refinement, particularly when dealing with unlabeled data or sequences prone to errors. Researchers introduce DNABERT-S,…

Read More Meet DNABERT-S: Illuminating Genomic Diversity through Species-Aware DNA Embeddings
AI | Bioinformatics | Cancer Research | Genomics | Neural Network | News | Paper Summary | Precision Medicine | Trending

Beyond One-Size-Fits-All: Moffitt Unveils First Individualized Predictive Model for the Treatment of Multiple Myeloma
ByDeotima Chakraborty February 15, 2024October 22, 2026

Patients with recently diagnosed non-differentiated multiple myeloma (NDMM) have a wide range of outcomes, with overall survival (OS) spanning from several months to more than ten years. In this work, the researchers gathered a significant training set and a validation set of NDMM patients with clinical, demographic, genomic, and treatment data for the construction of…

Read More Beyond One-Size-Fits-All: Moffitt Unveils First Individualized Predictive Model for the Treatment of Multiple Myeloma
Bioinformatics | Genomics | News | NGS | Paper Summary | Transcriptomics | Trending

Choosing the Best Tool for Identifying Transcriptional Regulators: Navigating the NGS Landscape
ByAnchal Negi February 12, 2024October 22, 2026

This article delves into a recent study undertaken by a team of researchers that examined multiple computer algorithms for transcriptional regulator prediction using Next-Generation Sequencing (NGS) data. Grasping biological processes and developing personalized medications necessitates a deep understanding of gene control. Transcriptional regulators (TRs) control the expression of certain genes, and NGS technology has enabled…

Read More Choosing the Best Tool for Identifying Transcriptional Regulators: Navigating the NGS Landscape
AI | Bioinformatics | Deep Learning | Gene Expression | Genomics | News | Paper Summary | Trending

Unlocking the Enhancer Code: Deep Learning’s Role in Designing Cell-specific Genetic Switches
ByAnchal Negi February 4, 2024October 22, 2026

Transcriptional enhancers control the spatiotemporal activation of the target genes they regulate by serving as docking stations for various transcription factor combinations. It has been a long goal to Decipher the regulatory logic of an enhancer and comprehend the specifics of how spatiotemporal gene expression is encoded in an enhancer sequence. Researchers from VIB Center…

Read More Unlocking the Enhancer Code: Deep Learning’s Role in Designing Cell-specific Genetic Switches
Bioinformatics | Genomics | News | NGS | Paper Summary | Transcriptomics | Trending

Probing Ancestral Genomes Uncovers Unannotated Degenerate Transposable Elements Contributing to Gene Regulation and Expression
ByDeotima Chakraborty February 3, 2024October 22, 2026

Transposable elements (TEs) supply genomes with both coding and non-coding sequences and have significant roles in evolution. However, the extent of TE annotations in each species has limited the identification of TE-derived functional components to reasonably intact TE sequences. Here, scientists from the École Polytechnique Fédérale de Lausanne, Switzerland, present a novel method that they…

Read More Probing Ancestral Genomes Uncovers Unannotated Degenerate Transposable Elements Contributing to Gene Regulation and Expression
AI | Bioinformatics | Biomarker Discovery | Disease Diagnosis | Genomics | Machine Learning | News | OMICS | Tools | Trending

IntelliGenes Unveiled: A New Paradigm for AI-Driven Biomarker Discovery from Multi-genomic Data
ByDr. Tamanna Anwar January 27, 2024October 22, 2026

IntelliGenes is a new machine learning pipeline developed by researchers at The State University of New Jersey that integrates multi-genomics, clinical, and demographic data to discover biomarkers for disease prediction with high accuracy. It implements Intelligent Gene (I-Gene) scoring to assess the significance of biomarkers and create individual profiles to understand disease prognosis. IntelliGenes is…

Read More IntelliGenes Unveiled: A New Paradigm for AI-Driven Biomarker Discovery from Multi-genomic Data
AI | Big Data | Cancer | Genomics | News | Trending

Alexa, Analyze Cancer Data: Meet Melvin, Your Virtual Genomics Assistant
ByDr. Tamanna Anwar January 7, 2024October 22, 2026

Researchers at the University of Singapore introduced “Melvin,” an Alexa Skill that lets you query cancer genomics data with your voice. This groundbreaking tool bypasses complex interfaces and empowers anyone to ask questions about massive cancer datasets through simple conversations. Melvin promises to democratize cancer research and personalized medicine by putting this life-saving information at…

Read More Alexa, Analyze Cancer Data: Meet Melvin, Your Virtual Genomics Assistant
AI | Big Data | Bioinformatics | Genomics | News | Paper Summary | Tools | Trending

Breaking Barriers in Genomic Research: DRAGEN Delivers Accurate Variant Detection in 30 Minutes
ByAnchal Negi January 7, 2024January 7, 2024

Scientists took decades to decode the complex code of DNA, and though we have come a long way, the journey is far from over. The development of DRAGEN sheds light on new unknown secrets, unlocking a deeper understanding of our bodies and nature around us. Illumina has always provided us with the best tools and resources, acting…

Read More Breaking Barriers in Genomic Research: DRAGEN Delivers Accurate Variant Detection in 30 Minutes
Bioinformatics | CRISPR | Genomics | News | NGS | Paper Summary | Sequencing | Tools | Trending

CReATiNG Synthetic Chromosomes in Yeast Opens New Possibilities in Synthetic Biology
ByDeotima Chakraborty December 25, 2023January 4, 2024

While chromosomal synthesis and cloning are expensive and time-consuming processes, CReATiNG (Cloning, Reprogramming, and Assembling Tiled Natural Genomic DNA), a method introduced by researchers at the University of Southern California, presents a viable substitute. With this technique, sections of natural chromosomes are cloned and put together to create synthetic chromosomes. CReATiNG can change a cell’s…

Read More CReATiNG Synthetic Chromosomes in Yeast Opens New Possibilities in Synthetic Biology
AI | Bioinformatics | Cancer | Genomics | News | NGS | OMICS | Transcriptomics | Trending

Spatial Transcriptomics Unlocks Novel Insights into Cancer Biology: AI Analyzes Gene Activity in 3D
BySonal Keni December 21, 2023January 4, 2024

The introduction of NGS transformed the field of biology, allowing for greater insights into biological mechanisms through the gathering of rich, accessible data. However, important context is lost due to the data being conventionally stored in tabular formats, which erase the impacts that spatial connectivity has on genes and gene expression. A new framework, GENIUS…

Read More Spatial Transcriptomics Unlocks Novel Insights into Cancer Biology: AI Analyzes Gene Activity in 3D
AI | Bioinformatics | Genomics | News | Paper Summary | Tools | Transcriptomics | Trending

BARtab and Bartools: Revolutionizing Cellular Barcoding Analysis in Genomics Research
ByDeotima Chakraborty December 4, 2023December 5, 2023

Researchers from the Peter MacCallum Cancer Centre, Australia, have introduced an integrated open-source toolset called BARtab and bartools to streamline the analysis of cellular barcoding experiments. Cellular barcoding couples heritable DNA barcodes to high-throughput sequencing to enable precise tracing of cell lineages across conditions. The new tools automate the computational processing of barcode datasets, quality control, filtering,…

Read More BARtab and Bartools: Revolutionizing Cellular Barcoding Analysis in Genomics Research
AI | Big Data | Bioinformatics | Genomics | LLM | News | OMICS | Paper Summary | Trending

Genome LLMs: Revolutionizing Genomics with Transformer-based Large Language Models
BySwasti Tyagi November 29, 2023November 29, 2023

Deep learning techniques have had a significant influence on genomics and the sequencing techniques employed in the field due to the exponential advancements in artificial intelligence (AI) and machine learning (ML) during the past ten years. The review article by a team led by researchers from the University of Toronto elucidates the advantages and drawbacks…

Read More Genome LLMs: Revolutionizing Genomics with Transformer-based Large Language Models
Bioinformatics | CRISPR | Drug Discovery | Genetic Engineering | News | Precision Medicine

UK Approves Revolutionary World-first Gene Editing Treatment for Blood Disorders
ByDr. Tamanna Anwar November 23, 2023October 22, 2026

The UK has achieved a historic milestone by becoming the first country to authorize a revolutionary new treatment for two serious inherited blood conditions – sickle cell disease and beta-thalassemia. The cutting-edge therapy utilizes CRISPR gene editing technology to precisely correct errors in patients’ blood stem cells, potentially curing them of debilitating symptoms. Announced earlier…

Read More UK Approves Revolutionary World-first Gene Editing Treatment for Blood Disorders
AI | Bioinformatics | Deep Learning | Genomics | News | OMICS | RNA-Seq | Sequencing | Tools | Trending

UCSD’s EUGENe: A New Deep Learning Toolkit to Decode the Regulatory Genome
ByDr. Tamanna Anwar November 22, 2023November 30, 2023

Researchers at the University of California, San Diego, built EUGENe (elucidating the utility of genomic elements with neural nets) – an end-to-end Python toolkit for analyzing genomic sequences using deep learning. EUGENe comprises a collection of modules and sub-packages designed to carry out the essential functions of genomics deep learning. EUGENe aims to enable computational…

Read More UCSD’s EUGENe: A New Deep Learning Toolkit to Decode the Regulatory Genome
AI | Bioinformatics | Cancer | Chronic Diseases | Genomics | News | OMICS | Paper Summary | Trending

Unlocking the Secrets of Disease: The Imageable Genome and the Future of Molecular Medicine
BySwasti Tyagi November 18, 2023November 18, 2023

Researchers at the University of Lucerne utilized molecular imaging to evaluate the expression of certain regions of the human genome. The imaging techniques are part of an AI pipeline that involves human-robot cooperation using deep learning-based artificial intelligence (AI) tools. This would link discrete genes to the diseases that they could possibly be responsible for….

Read More Unlocking the Secrets of Disease: The Imageable Genome and the Future of Molecular Medicine
Bioinformatics | Gene Expression | Genomics | GWAS | News | Paper Summary | Trending

MIT’s iPGS: A New Inclusive Polygenic Scoring Model Revolutionizes Disease Risk Assessment for Diverse Populations
BySwasti Tyagi November 11, 2023November 11, 2023

Massachusetts Institute of Technology (MIT) computer scientists developed iPGS, a model that gives accurate polygenic score calculations for the genetic makeup of individuals belonging to diverse ancestral backgrounds. Diversity in human beings can be attributed to the 0.1% of DNA that varies across individuals. It determines the phenotypes that would be expressed as well as…

Read More MIT’s iPGS: A New Inclusive Polygenic Scoring Model Revolutionizes Disease Risk Assessment for Diverse Populations
AI | Bioinformatics | Metagenomics | News | Paper Summary | Tools | Transcriptomics | Virus

Meet geNomad: A Cutting-Edge Tool for Mobile Genetic Elements Detection
ByPrachi Khare October 31, 2023November 1, 2023

Mobile genetic elements (MGEs) are transposable elements or transposons, which are DNA sequences that have the ability to move within a genome. They are found in various species like bacteria, plants, animals, and humans. They rely on whose cells to replicate and propagate. Plasmids and viruses lead to horizontal gene transfer, which impacts the valuation…

Read More Meet geNomad: A Cutting-Edge Tool for Mobile Genetic Elements Detection
Bioinformatics | Genomics | Machine Learning | News | Paper Summary | Sequencing | Trending

Mosaic Variant Calling: Benchmarking Approaches and Unveiling Best Practices
BySwasti Tyagi October 23, 2023October 22, 2023

Scientists from Yonsei University College of Medicine, Republic of Korea, have developed a new benchmark for evaluating mosaic variant calling methods, which are used to detect genetic mutations in individuals. The benchmark will help researchers select the most suitable calling algorithms for their studies and guide developers in improving the accuracy of these methods. The…

Read More Mosaic Variant Calling: Benchmarking Approaches and Unveiling Best Practices
Bioinformatics | Genomics | News | NGS | Paper Summary | RNA-Seq | Tools | Transcriptomics | Trending

Accurate Annotation of Eukaryotic Genomes Made Easy: The BRAKER3 Advantage
ByPrachi Khare September 25, 2023September 30, 2023

Researchers from the University of Greifswald, Germany, introduced a new version of the BRAKER software BRAKER3, notably improving the annotation of eukaryotic genomes. Its superior performance in eukaryotic genome annotation, particularly for species with large and complex genomes, signifies a promising advancement in bioinformatics with far-reaching implications for genomic research and applications in diverse fields….

Read More Accurate Annotation of Eukaryotic Genomes Made Easy: The BRAKER3 Advantage
Big Data | Bioinformatics | Database | Genomics | News | Paper Summary | Trending

Functional Unknomics: Exploring the Untapped Potential of Unknown Genes Leveraging Unknome Database
ByAditi Sarkar August 16, 2023August 29, 2023

Unstudied areas of life sciences, including uncharacterized or less characterized genes and proteins, have now got an exclusively dedicated repository through the recent works of scientists affiliated with the MRC Laboratory of Molecular Biology, Cambridge; the University of Cambridge and the University of Oxford, United Kingdom. The open source database ‘Unknome’ is now the repertoire…

Read More Functional Unknomics: Exploring the Untapped Potential of Unknown Genes Leveraging Unknome Database
AI | Bioinformatics | Deep Learning | Epigenomics | News | OMICS | Paper Summary | Tools | Trending

Ameliorating the Chromatin Landscape: ChromaFold’s Accurate 3D Contact Map Prediction from scATAC-seq Data
ByAditi Sarkar August 6, 2023August 6, 2023

USA-based researchers have formulated a supervised deep learning model, ChromaFold, that has achieved state-of-the-art performance in cell-type-specific prediction of 3D contact maps and regulatory interactions only utilizing single-cell ATAC sequencing (scATAC-seq) data, bypassing the prerequisite of multiple input data modalities. Additionally, the lightweight architecture of ChromaFold brings compatibility with standard GPUs; its ability to make…

Read More Ameliorating the Chromatin Landscape: ChromaFold’s Accurate 3D Contact Map Prediction from scATAC-seq Data
AI | Bioinformatics | Cancer Research | Genomics | News | Paper Summary | Trending

Scientists Used a Netflix-Style Algorithm to Create Blueprint of Cancer Genomes
ByTanveen Kaur June 20, 2022November 9, 2022

The algorithms that track users’ Netflix viewing habits could soon be used to track cancer development in order to direct doctors in managing cancer. An international team of researchers led by Dr. Nischalan Pillay (UCL Cancer Institute) and Dr. Ludmil Alexandrov (University of California, San Diego) used AI to identify 21 frequent faults in the…

Read More Scientists Used a Netflix-Style Algorithm to Create Blueprint of Cancer Genomes
Bioinformatics | COVID-19 | Drug Discovery | Gene Expression | Genomics | GWAS | Machine Learning | News | OMICS | Paper Summary | Trending

Transcriptome-Wide Association Studies Integrated with 3D Genomic and Epigenomic Data used to Improve Target Gene Discovery and Drug Repurposing
ByTanveen Kaur June 13, 2022October 22, 2026

Scientists from Pennsylvania State University integrated 3D genomic and epigenomic data with transcriptome-wide association studies data to improve gene expression predictions. The researchers propose an integrative method PUMICE that integrates 3D genomic and epigenomic data with expression quantitative trait loci (eQTL) to predict gene expressions more accurately. An extension of the method PUMICE +, also combines transcriptome-wide…

Read More Transcriptome-Wide Association Studies Integrated with 3D Genomic and Epigenomic Data used to Improve Target Gene Discovery and Drug Repurposing
Algorithm | Bioinformatics | Genomics | Machine Learning | News | NGS | Sequencing | Tools | Trending

‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up DNA Sequencing
ByDr. Tamanna Anwar May 21, 2022June 18, 2022

The algorithm is the first full-fledged machine learning-based short read alignment algorithm to speed up DNA sequencing, that efficiently uses learned indices to solve the exact match search issue for efficient seeding. The human genome is made up of a whole set of DNA that is around 6.4 billion letters long. Reading the entire genome…

Read More ‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up DNA Sequencing
Bioinformatics | Biotech | Machine Learning | News | Structural Biology | Trending

Structure Modeling with a New Method Mapped 500 Previously Unsolved Proteins
ByDr. Tamanna Anwar January 20, 2022June 18, 2022

Pathogens employ virulence factors called effectors, which are critical for their survival. Homology modeling is one of the most extensively used approaches; however, it necessitates the usage of templates of solved effector structures, and solving all of them is far too difficult. There are just too many effector proteins encoded in pathogen genomes for each…

Read More Structure Modeling with a New Method Mapped 500 Previously Unsolved Proteins

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Genomics

Meet DNABERT-S: Illuminating Genomic Diversity through Species-Aware DNA Embeddings

UK Approves Revolutionary World-first Gene Editing Treatment for Blood Disorders

Meet geNomad: A Cutting-Edge Tool for Mobile Genetic Elements Detection

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