Genome LLMs: Revolutionizing Genomics with Transformer-based Large Language Models
Deep learning techniques have had a significant influence on genomics and the sequencing techniques employed in the field due to the exponential advancements in...
The Tail that Wiggles: A Reaction-Diffusion Model Unveils the Mechanism Behind...
The graceful, rhythmic beating of slender cellular appendages called flagella allows sperm cells and microorganisms like algae to swim. But how these waving motions...
Transforming Infection Diagnosis: Saliva-Based mRNA Biomarker for Accurate Detection
Since the COVID pandemic began, the world has been reminded of the poor reliability of elevated body temperature for detecting infections. Even when infected...
Meet NeuroVelo: A New Tool to Decode Cellular Dynamics from Single-cell...
A study conducted at the International School for Advanced Studies (SISSA) in Trieste, Italy, introduced NeuroVelo, a novel method tackling the challenge of reconstructing...
New Machine Learning Technique Predicts Cancer Patient Cure Rates More Accurately
As computing power has exponentially grown, machine learning (ML) techniques have gained immense popularity in healthcare - including predicting outcomes for patients with devastating...
UK Approves Revolutionary World-first Gene Editing Treatment for Blood Disorders
The UK has achieved a historic milestone by becoming the first country to authorize a revolutionary new treatment for two serious inherited blood conditions...
UCSD’s EUGENe: A New Deep Learning Toolkit to Decode the Regulatory...
Researchers at the University of California, San Diego, built EUGENe (elucidating the utility of genomic elements with neural nets) – an end-to-end Python toolkit...
Enlightening the Proteomic Space with Chroma: A Revolutionary Generative Model for...
Proteins are incredible molecules that carry out nearly every function necessary for life. However, their staggering complexity has made designing new proteins an immensely...
Unravel Cell-cell Communication with CellPhoneDB v5: A Cutting-edge Single-cell Multiomics Toolkit
We often underestimate the crucial role played by communications between cells to sustain living organisms. Flawless communication between cells is a necessity to maintain...
Unlocking the Secrets of Disease: The Imageable Genome and the Future...
Researchers at the University of Lucerne utilized molecular imaging to evaluate the expression of certain regions of the human genome. The imaging techniques are...
Demystifying Big Data with TBtools-II: A Versatile and Customisable All-in-One Platform...
TBtools, a toolkit used for data analysis and bioinformatics tasks, was released in 2020 and quickly found a large audience – thousands of researchers...
Meet MiRGraph: A Novel Deep Learning Algorithm to Predict miRNA-target Interactions
A team of researchers from McGill University and Hunan University developed MiRGraph, a multi-view feature-learning method based on transformers that have the ability to...
Navigating the Complex Transcriptomic Landscape of Neurodegeneration with ZEBRA
Neurodegenerative diseases like Alzheimer's and Parkinson's remain poorly understood despite intensive research. While sequencing studies have profiled diverse brain cell populations, integrating findings into...
Meet A3D-MODB: A New Database for Predicting Protein Aggregation in Model...
The Protein Folding and Computational Diseases Group at IBB-UAB, in collaboration with researchers from the University of Warsaw, developed a new database, A3D-MOBD (A3D...
Harnessing Artificial Intelligence to Decode Sudden Cardiac Death
Sudden cardiac death, the abrupt loss of heart function leading to mortality, accounts for up to 20% of passings globally. Despite being a major...
MIT’s iPGS: A New Inclusive Polygenic Scoring Model Revolutionizes Disease Risk...
Massachusetts Institute of Technology (MIT) computer scientists developed iPGS, a model that gives accurate polygenic score calculations for the genetic makeup of individuals belonging...
DeepSA: A Cutting-edge Chemical Language Model for Compound Synthesis Accessibility Prediction
As computationally generated molecules become more popular in the fields of drug development and biotechnology, ease of synthesis becomes a common problem. Often, the...
EasyDock: A Scalable and User-friendly Tool for High-throughput Molecular Docking
Computational tools that are currently used for molecular docking are difficult to integrate into different computational distributions and interfaces; this becomes very inconvenient for...
Illuminating the Molecular Landscape of Disease with DiSignAtlas
Identifying the complex molecular changes underlying diverse diseases remains a grand challenge in biomedicine. While high-throughput omics technologies have enabled unbiased interrogation of disease...
Cellsnake: A New Tool Makes Single-cell RNA Sequencing Analysis Easier Than...
A collaborative effort between several medical departments at the University of Oslo led to the development of Cellsnake, a convenient tool for users to...
The AlphaFold Revolution Continues: Unraveling the Next-Gen Advancements
The introduction of AlphaFold 2 was a groundbreaking breakthrough in the field of predicting protein structures and interactions. Google's DeepMind, was the driving force...
Deep Learning Meets Clinical Microbiology: Unveiling DeepColony for Automated Culture Plates...
The introduction of Full Laboratory Automations has served to revolutionize the workflows of labs worldwide, helping with the automation of routine tasks and the...
Demystifying the Genetic Architecture of Proteins through Experimental Models
A collaborative effort between researchers from the UK, Spain, and Germany utilized experimental methods to explore amino acid sequence spaces and demonstrated that for...
Illuminating the Complexity of Interactions within and between Proteins and Ligands...
Computational methods have revolutionized our understanding of molecular interactions and their pivotal role in the stability of biomolecular structures and complexes. These insights are...
Meet geNomad: A Cutting-Edge Tool for Mobile Genetic Elements Detection
Mobile genetic elements (MGEs) are transposable elements or transposons, which are DNA sequences that have the ability to move within a genome. They are...
New Advances in De Novo Protein Design Open the Door to...
Protein engineering is a fast-growing area of biotechnology. Responsible for carrying out nearly every biological function, the question of how to reliably engineer them...
Alignment-Based DNA Language Models: The GPN-MSA Approach Enables Accurate Genome-wide Variant...
In the dynamic landscape of biology, researchers around the world aim to unlock the secrets held in the genetic code. With the introduction of...
New Deep Learning Framework ‘DEMINING’ Distinguishes DNA and RNA Mutations Directly...
Researchers have introduced a groundbreaking computational framework called DEMINING, designed to directly identify expressed DNA and RNA mutations in RNA deep sequencing data. This...
Visualizing Complex Biological Networks with ‘ggkegg’
The Kyoto Encyclopedia of Genes and Genomes (KEGG) database serves as an invaluable resource for systems biology research across diverse fields. It provides comprehensive...
Meet BTR: A Deep Learning Powered Bioinformatics Tool Recommendation System Revolutionizing...
With the rise in popularity of the field of bioinformatics in recent years, researchers have created multiple computational tools that help streamline and optimize...
Meet ggCaller: A Fast and Accurate Solution for Pangenome Annotation and...
Pangenomic annotation is critical for understanding the bacterial genomic variety and depends on recognizing core and accessory genes through gene prediction and clustering. These...
Deep Learning Unveils Antimalarial Drug’s Potential to Combat Osteoporosis
Scientists at Peking University School and Hospital for Stomatology, China, have used deep learning to identify dihydroartemisinin (DHA), an antimalarial drug, as a potential...
Mosaic Variant Calling: Benchmarking Approaches and Unveiling Best Practices
Scientists from Yonsei University College of Medicine, Republic of Korea, have developed a new benchmark for evaluating mosaic variant calling methods, which are used...
Machine Learning Modeling Helps Uncover Links Between Gut Microbiome and Heart...
Heart failure is widely recognized as a leading cause of mortality worldwide. Though there have been great strides made in medical technology over the...
A Comprehensive Look at Lactic Acid Bacteria: Pangenome Analysis Reveals New...
Researchers from the University of California, San Diego, and the Technical University of Denmark have conducted a comprehensive pangenomic analysis of the Lactobacillaceae family, a crucial...
Decoding Cellular Interactions with DeepCCI: A Deep Learning Approach to Analyze...
Cell-cell interactions (CCIs) are pivotal in various biological functions, including cellular differentiation, tissue maintenance, and immune reactions. As single-cell RNA sequencing (scRNA-seq) techniques advance,...
MIT Scientists Discover Thousands of New Programmable DNA-Cutting Enzymes Opening the...
Through the advent of CRISPR-Cas12, scientists have managed to unlock a new world of gene editing and reprogramming, with important applications for diagnostics, therapeutics,...
Fast-tracking CNS Tumor Diagnosis: New AI System ‘Sturgeon’ Accurately Diagnoses Brain...
Tumors that affect the central nervous system are among the most fatal kinds of cancer, especially in pediatric cases. Surgical removal of the tumor...
Pharmacophore-Guided Deep Learning: A New Paradigm for Generating Bioactive Molecules in...
One of the biggest challenges to drug discovery is designing molecules that express desired biological activity, also referred to as bioactivity. This is of...
Meta-analysis of 13000 Salmonella Typhi Genomes Unravels Global Diversity and Drug...
Typhoid, once a disease that ravaged countries, had been considered tamed by the introduction of new antibiotics in the mid-20th century. Awareness of the...
Variational Auto-encoders for Ligand Generation: A New Approach to Drug Discovery
The search for molecules that bind effectively to specific proteins is crucial from a drug discovery point of view. The existing methods for creating...
A New Deep Neural Networks-Based Method Predicts Protein Abundance Based on...
With the potential to have significant impacts on various fields, like therapeutics and agritech, protein engineering has recently been a subject that has incited...
Researchers Develop Neural Network for Genomics that can Explain its Prediction...
A breakthrough by a group of researchers at New York University resulted in the development of an interpretable neural network that can explain the...
New Findings Challenge Traditional Rules of Genetics: UAA and UAG Codons...
Scientists from the Earlham Institute and the University of Oxford have unexpectedly altered our understanding of the rules of genetics while testing a new...
The Rise of mRNA Vaccines: A Game-Changer for Public Health?
The emergence of mRNA vaccine technology represents a monumental leap forward in disease prevention. A review article published in Nature Reviews Drug Discovery by...
A New Active Learning Model Makes Cellular Reprogramming and Genetic Intervention...
Millennia of evolution has allowed life to flourish in a million different ways, each suited to the niches it fills. The advent of CRISPR...
Massive Structural Clustering of the AlphaFold Database using Foldseek Cluster Reveals New...
Hundreds of millions of protein structures can be clustered using the new AI algorithm "Foldseek Cluster," which was developed by a team of researchers...
The Rise of Scientific Language Models: Revolutionizing Molecular Discovery
In a groundbreaking collaboration spanning IBM Research in Switzerland and the USA, scientists have illuminated the pivotal role of language models (LMs) in molecular...
Advancing Continuous Blood Pressure Monitoring: Accurate Measurements with Multichannel Sensing Signals...
Hypertension has long been known to be a causative factor for a multitude of medical ailments. Hypertension has further been noticed to have significantly...
GeneCompass: A New Foundation Model that Unlocks the Secrets of Gene...
A team of researchers from the University of Chinese Academy of Sciences, China, and collaborators developed GeneCompass, one of the first foundation models of...
Must Read
D-I-TASSER Outperforms AlphaFold? A New Frontier in Protein Structure Modeling
The requirement and utility of conventional force field-based folding simulations have been called into question by the overwhelming success of deep learning techniques in...
Unlocking Biomolecular Secrets with AF3Score: A Leap Forward in Structural Evaluation
Researchers from Changping Laboratory in Beijing introduced AF3Score, a novel adaptation of AlphaFold3 designed to evaluate biomolecular structures with unprecedented accuracy. This innovation addresses...
Overlapping Genes, Unfolding Insights: Synthetic Biology Meets AI
Given that the sharing of codon nucleotides dramatically reduces the size of protein sequences, viruses in nature often generate overlapping genes (OLG) in alternate...
PhysDock: A New Era in Protein-Ligand Docking with AI and Physics
In a breakthrough that could transform drug discovery, a team of researchers from ShanghaiTech University has introduced PhysDock, a novel AI-powered model designed to...
Advancing Enzyme Design: RFdiffusion2 Enables Atomic-Level Scaffold Generation
In de novo enzyme design, the functional groups surrounding reaction transition states are described in the optimal active site. There are drawbacks to the...