MIT Introduces PRISM: Advancing Early Detection of Lethal Pancreatic Cancer with...
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive cancer with a poor prognosis, owing mostly to late diagnosis. Expanding screening beyond the 10% now...
Unlocking Brain Mysteries with BrainLM: A Versatile Foundation Model for Recording...
The Brain Language Model (BrainLM), a foundation model for brain activity dynamics trained on 6,700 hours of functional magnetic resonance imaging (fMRI) scans, was...
MIT’s Noninvasive Technique “Raman2RNA” Reveals Cells’ Gene Expression Dynamics Over Time
Understanding cell dynamics, regulation, and characteristics has been revolutionized by profiling tests at a previously unheard-of resolution. Nevertheless, the destructive nature of these techniques...
The Glue that Heals: St. Jude’s Researchers Unveil Molecular ‘Super-Glue’ Propelling...
Scientists at St. Jude Children's Research Hospital have published their findings on SJ3149, a chemical with broad efficacy against various cancer types, particularly acute...
Fighting Pathogens Smarter: How Machine Learning and Data Integration Improves Bacterial...
CRISPR interference (CRISPRi) is one of the most widely used CRISPR technologies in bacteria. In this, a catalytically dead Cas protein incapable of DNA...
Mapping Cancer’s Weaknesses: A Comprehensive Map of Cancer Cell Dependencies Accelerates...
Cancer, a simple name for a complicated group of diseases, has long perplexed scientists and healthcare professionals alike. Despite years of research and medical...
Language Models Paired with Geometric Deep Learning Revolutionize Genome-scale Protein Binding...
Protein structures depend on nucleic acids and tiny ligands to establish binding sites. Accurate identification of these locations is necessary due to the exponential...
Integrating Genomic and Clinical Data from the 100,000 Genomes Cancer Program...
In order to establish standardized high-throughput whole-genome sequencing (WGS) for patients with cancer and rare diseases, the UK Government launched the groundbreaking 100,000 Genomes...
Illuminating AMBERff’s Potential: AMBER Force Fields Meet NAMD in Multimillion-Atom Simulations
AMBERff with NAMD is implemented by researchers from the University of Delaware to enable simulations of large systems built upon existing software infrastructure. Increasingly...
High-throughput ADMET Properties Prediction Made Easy with ADMET-AI: A New Platform...
A vital step in drug discovery is accurately evaluating potential drug candidates' Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET). Traditionally, this process has been...
New Principles Underlying Neural Activity Discovered With Startling Implications For Machine...
One of the biggest challenges in the machine learning space today is the problem of credit assignment: the identification of the components within the...
BaseMEMOIR: Breakthrough in Cell Lineage Tracing with Image-readable Base Editor Recording
For decades, tracing the lineage of individual cells has been a difficult and unreliable task. Existing methods like dye labeling and genetic barcoding have...
Scripps Scientists Develop High-Resolution Method to Uncover Druggable Sites on Proteins
The factors at play in the binding of proteins are intricate and hard to untangle - despite great advancements in recent years in humanity’s...
Cracking the Code of Complex Diseases: Utilizing FORGEdb to Identify Functional...
A majority of variations linked to disease that have been found by genome-wide association studies are not found in areas that code for proteins....
From PCA to PCA-Plus: Advancing Principal Component Analysis for More Robust...
PCA (Principle Component Analysis) is a commonly used technique in biomedical research to identify similarities and differences between groups of samples. Though conventional PCA...
Mount Sinai Researchers Introduce mEnrich-seq: A New Approach to Enriching Taxa...
In this study, researchers at Icahn School of Medicine developed mEnrich-seq, a method that can enrich taxa of interest from metagenomic DNA before sequencing....
Alexa, Analyze Cancer Data: Meet Melvin, Your Virtual Genomics Assistant
Researchers at the University of Singapore introduced "Melvin," an Alexa Skill that lets you query cancer genomics data with your voice. This groundbreaking tool...
Breaking Barriers in Genomic Research: DRAGEN Delivers Accurate Variant Detection in...
Scientists took decades to decode the complex code of DNA, and though we have come a long way, the journey is far from over....
Exploring the Diversity of Scavenger Receptor Class B Proteins Across Eukarya:...
The class B scavenger receptor (SR-B) proteins, which are essential for innate immunity, pathogen identification, apoptotic cell clearance, and metabolic sensing, have an ectodomain...
AlphaFold’s Latest Strides: Improved Accuracy for Antibody-Antigen Complex Modeling
The launch of AlphaFold signaled a revolution in computational modeling: armed with new knowledge of protein structures and unencumbered by limitations on resources and...
Unleashing MACE-OFF23: Machine Learning Empowers Transferable Force Field for Organic Molecules
For more than fifty years, biomolecular simulation has been dominated by classical empirical force fields. Despite being extensively employed in biomolecular dynamics, crystal structure...
Bridging Gaps in Drug Discovery: Allosteric Atlases Illuminate Therapeutic Avenues in...
Many proteins are regarded as "undruggable" because of their activity through protein-protein interactions, despite the fact that they have been discovered as therapeutic targets...
Meet LigandMPNN: A Deep Learning Model Redefining Protein Design with Precision...
Protein design is an upcoming niche with important implications for many fields in the realms of healthcare, genetic engineering, and drug creation, among others....
Top 10 Bioinformatics Breakthroughs of 2023!
In 2023, bioinformatics discoveries have catalyzed immense progress across the life sciences landscape. These ground-breaking discoveries have provided insight into the complex workings of...
ChIP-DIP Multiplexing Method Maps Hundreds of Proteins to DNA Decoding Gene...
The dynamic localization of thousands of unique regulatory proteins to specific DNA sequences regulates the expression of genes. It has been a longstanding objective...
CellHint Revolutionizes Human Cell Atlas: Automatic Cell Type Harmonization Paves the...
Over the past few years, a large number of single-cell genomics datasets that profile a range of tissues in different stages of development have...
BROAD Scientists Introduce Slide-tags: A Novel Method for Mapping Cells in...
Despite huge leaps being made in the field of gene profiling in recent years, few of the tools developed for single-cell and single-nucleus sequencing...
Designing Drug-like Molecules with DrugHIVE: A Deep Hierarchical Variational Autoencoder for...
Due to the rapid advancements in AI, structure-based medication design is now widely used as one of the most important methods in early drug...
How Well Can LLMs Really Perform Bioinformatics Tasks? BioLLMBench Has Answers
Artificial intelligence is transforming industries across the board, and the life sciences are no exception. A new study led by researchers at Anthropic, an...
MIT Researchers Use AI to Design New Class of Antibiotic Candidates...
Since the discovery of penicillin, a large number of antibiotics have been developed and used all over the world as a means to cure...
CReATiNG Synthetic Chromosomes in Yeast Opens New Possibilities in Synthetic Biology
While chromosomal synthesis and cloning are expensive and time-consuming processes, CReATiNG (Cloning, Reprogramming, and Assembling Tiled Natural Genomic DNA), a method introduced by researchers...
Genetic Insights for a Longer Life: Exploring Actionable Genotype Testing
A new study from deCODE genetics on actionable genotypes shows the potential of genetics to guide healthcare and improve outcomes. The research, published in the New England...
Real-Time Cellular Analysis on Your Wrist: ‘Genomic Smartwatch’ May Offer Continuous...
A 'Genomic Smartwatch' technology initiative launched by the Seattle Hub for Synthetic Biology will provide instantaneous observations of individual cell transformations, potentially transforming the landscape of...
A GPT-driven Robot Chemist Designs, Plans, and Performs Complex Experiments –...
Scientists at Carnegie Mellon University have unveiled a breakthrough artificial intelligence system called Coscientist that can independently design and execute complex chemistry experiments at the touch...
Spatial Transcriptomics Unlocks Novel Insights into Cancer Biology: AI Analyzes Gene...
The introduction of NGS transformed the field of biology, allowing for greater insights into biological mechanisms through the gathering of rich, accessible data. However,...
New AI Model Predicts Life Outcomes from Health and Career Data
Artificial intelligence continues advancing into uncharted territory, now claiming the ability to peek into people's futures. Researchers from the Technical University of Denmark have...
Atomic AI’s ATOM-1: Leveraging Chemical Mapping Data to Optimize RNA Therapeutics
New avenues are being paved in the world of healthcare every day. One of the most promising new developments is the creation of RNA-based...
Google Unveils MedLM – New AI Models to Transform Healthcare
Google recently announced the launch of MedLM, a family of large language models specifically fine-tuned to revolutionize medicine and life sciences. MedLM brings the...
The Rising Potential of Deep Neural Networks in Mimicking Brain Responses...
One of the primary challenges contemporary neuroscience researchers face is building a successful and accurate computational model of the various sensory systems in the...
New AI Model ‘popEVE’ Accelerates Rare Disease Diagnosis by Predicting Most...
A newly developed AI model called popEVE shows promising results for accelerating the diagnosis of rare genetic disorders by predicting which mutations in a...
Unlocking the Mysteries of the Mammalian Brain: A Comprehensive Atlas Reveals...
Scientists from the Broad Institute have made a groundbreaking discovery in the field of neuroscience by mapping the locations of hundreds to thousands of...
Stanford Medicine Scientists Inch Closer to Predicting Which of Our Organs...
In a recently published study, Stanford Medicine researchers highlighted age-related problems in humans and showed how aging varies from person to person and between...
A New Era in Diabetes Assessment: Skin Scanner and AI Score...
A new non-invasive imaging technique called raster-scan optoacoustic mesoscopy (RSOM) shows promise for detecting diabetes progression and severity by visualizing microscopic changes in the...
Broad Institute Researchers Unveil a New “Dictionary” of Immune Responses to...
A research team led by Prof. Nir Hacohen from the Broad Institute of MIT and Harvard, Cambridge, designed the study Dictionary of Immune Responses...
Analyzing Bio-Ontologies Made Easy: A Deep Dive into simona R Package...
As modern biology embraces high-throughput genomics and multi-omics profiling, the torrents of data now routinely generated necessitate improved systems organizing information to enable meaningful...
Unleashing the Power of Recurrent Neural Networks for Orally Bioavailable Drug...
NovoMol is a novel de novo technique that increases the efficiency of clinical trial times by mass-generating therapeutic molecules with excellent oral bioavailability through...
Meet Multiple Protein Profiler: A New Tool for Analyzing Proteomic Datasets
Dalhousie University, Canada researchers have developed a new web-based tool called Multiple Protein Profiler (MPP) that can efficiently calculate 12 key physicochemical properties of...
French Startup Selling $1,000 DNA Cards Capable of Storing Messages in...
Biomemory, a French digital storage startup, recently unveiled encapsulated DNA storage devices the size of credit cards, holding personalized messages as brief proofs of...
Unlocking the Secrets of Life: Universal Cell Embeddings – A Revolutionary...
Universal Cell Embedding (UCE) is a foundation model proposed by a group of scientists from Stanford University. Using a corpus of cell atlas data...
Revolutionizing Molecular Dynamics Analysis with VIAMD: A Unified Approach to Visualization,...
Many different tools are needed for the standard molecular dynamics (MD) analysis workflow, which frequently leads to a lack of coordination and interaction between...
Must Read
Unveiling Bioinformatics Copilot 1.0: A Cutting-Edge LLM-Driven Solution for Transcriptomic Data Analysis
Single-cell transcriptomics has been generating large-scale information, improving our knowledge of cellular processes across different tissues, and facilitating medication discovery, diagnosis, and prognosis. But...
Decoding Proteins with DeProt: A Breakthrough in Language Modeling through Quantized Structure and Disentangled...
Conventional representational models of protein functions have demonstrated notable performance in downstream tasks; nevertheless, they frequently do not incorporate explicit information on protein structure,...
Empowering Clinicians: How ‘Tyche’ Revolutionizes Medical Image Analysis with AI to Address Uncertainties
Just think about yourself as a physician examining an x-ray. You see an area that seems out of the ordinary, but you are unsure...
Unlocking Protein Co-regulation: How Genomic Language Models Illuminate Function Predictions
Are you aware of the perception of a genomic language model? If not, then it's worth mentioning that researchers at Harvard, Cornell University, and...
A New Era in Interactomics: Exploring Predictomes, the AlphaFold-Modeled Protein Interaction Database
Imagine a teeming city where proteins are the movers and shakers. Each protein intertwines with others in partnerships that are vital to every cellular...