ToposBio Unveils Topos-1: An All-Atom Foundation Model for Intrinsically Disordered Proteins
Intrinsically disordered proteins (IDPs) are proteins that are central to neurodegenerative diseases and aggressive cancers like prostate cancer, have been considered ‘undruggable’ as structures...
CleaveNet Enables Scalable and Targeted Protease Substrate Design for Diagnostics and Therapeutics
Scientists from MIT and Microsoft Research present CleaveNet, an AI-based pipeline that merges predictive and generative modeling for end-to-end peptide (short protein) design. By...
Advancing Peptide Therapeutics with PeptiVerse’s Unified Prediction Framework
Researchers at the University of Pennsylvania developed PeptiVerse, a single platform that predicts drug-related properties of therapeutic peptides using either amino acid sequences or...
Human Genome in 4D: Mapping Structure, Function, and Dynamics
An integrated atlas of the human 4D genome just dropped, and it is breathtaking in its ambition. In a massive consortium effort, researchers from...
Redefining SBDD: PackDock Speeds Up Accurate Protein-Ligand Docking with Diffusion Models
Researchers from the University of Shanghai, China, created PackDock, a diffusion-based side-chain packing model that predicts diverse side-chain conformations in protein binding pockets, both...