Sequencing

Bioinformatics | News | Paper Summary | RNA-Seq | Sequencing | Trending

New Bacterial Anti-Viral Defense System Revealed: How mRNA Alteration Stops Infection
ByAnchal Negi November 12, 2024October 22, 2026

As biologists have noticed, evolution has modified both bacteria and bacteriophages (i.e., viruses of bacteria), making them more complex on a smile’s molecular level. Weissman and his colleagues, Vassalo, Doering, Laub, and Michael (2007), made progress in resolving this molecular ‘cold war’ through this study, which was based on primary research performed at the Massachusetts…

Read More New Bacterial Anti-Viral Defense System Revealed: How mRNA Alteration Stops Infection
Bioinformatics | Cancer | Genomics | News | Paper Summary | Sequencing | Trending

Exploring Mitochondrial DNA Mutations with Mosaicism in Cancer and Aging
ByNeermita Bhattacharya November 10, 2024October 22, 2026

Currently, we know that genomic variations are gathered up in somatic cells as one age, but we have a limited understanding of mitochondrial DNA (mtDNA) mosaicism. mtDNA has many effects on various diseases, particularly cancer, and they might have a role in the aging process. Unlike nuclear DNA, which is inherited from both parents, mtDNA…

Read More Exploring Mitochondrial DNA Mutations with Mosaicism in Cancer and Aging
Bioinformatics | Genomics | News | Paper Summary | Sequencing | Transcriptomics | Trending

Expansion in situ Genome Sequencing: A New Tool for Studying Nuclear Abnormalities
ByAnchal Negi October 1, 2024October 22, 2026

The investigation of nuclear anomalies and how they influence the regulation of genes warrants analysis of various cellular functions and diseases. The researchers from MIT, Harvard, and the University of California San Francisco describe a new approach, Expansion in situ Genome Sequencing (ExIGS), that allows, for the first time, to unravel the relationship between nuclear…

Read More Expansion in situ Genome Sequencing: A New Tool for Studying Nuclear Abnormalities
Big Data | Bioinformatics | Genomics | News | OMICS | Paper Summary | Sequencing | Trending

Personalizing Pangenomes: A New Approach to Reduce Reference Bias
ByAnchal Negi September 20, 2024October 22, 2026

In a groundbreaking study published in Nature Methods, a group of scientists consisting of the UC Santa Cruz Genomics Institute, University of Ferrara, Google LLC, and others individuated a new way of building customized pangenome references. The researchers made a great step forward in genomic research as they managed to overcome certain limitations of the…

Read More Personalizing Pangenomes: A New Approach to Reduce Reference Bias
AI | Bioinformatics | News | Paper Summary | PLM | Proteomics | Sequencing | Trending

Unleashing the Power of Protein Language Models for Accurate Peptide Sequencing
ByNeermita Bhattacharya August 16, 2024October 22, 2026

Protein structure is important and should be studied to understand many biological processes and disease progressions. There are many advancements using machine learning techniques, but accurate protein sequencing remains a challenge in the field. Protein sequencing typically depends on mass spectrometry (MS), and they face limitations in accurately identifying all the amino acids. Researchers from…

Read More Unleashing the Power of Protein Language Models for Accurate Peptide Sequencing
AMR Alert | Antibiotic Resistance | Bioinformatics | Genomics | Infectious Diseases | News | NGS | Paper Summary | Sequencing | Trending

Can Real-Time Genomics Change the Game of Detecting Antibiotic Resistance?
ByAnchal Negi July 19, 2024October 22, 2026

Antibiotic resistance is increasing as a global problem, meaning previously effective treatments for bacterial infections have ceased to work. It is vital to accurately identify the antibiotic resistance profile of an infection to choose the right antibiotic and improve patient outcomes. In Germany, researchers from the Technical University of Munich (TUM) are exploring this possibility…

Read More Can Real-Time Genomics Change the Game of Detecting Antibiotic Resistance?
AI | Bioinformatics | News | OMICS | Paper Summary | RNA | Sequencing | Trending

Decoding the Impact of Mutations: Interface-Guided Phenotyping of RUNX1 Transcription Factor Reveals New Insights
ByAnchal Negi July 16, 2024October 22, 2026

Researchers from the University of California deploy SEUSS (scalable functional screening by sequencing), a perturb-seq method, to analyze single-gene missense mutations, which have been notoriously difficult to interpret. The study focused on mutations in the RUNX1 gene, which is associated with myelogenous leukemia. Using SEUSS, the team evaluated 115 mutations and categorized them into three…

Read More Decoding the Impact of Mutations: Interface-Guided Phenotyping of RUNX1 Transcription Factor Reveals New Insights
Bioinformatics | Gene Expression | Genomics | News | Paper Summary | Sequencing | Trending

Did Aquatic Algae Pave the Way for Lush Forests? New Research Suggests Yes!
ByAnchal Negi May 8, 2024October 22, 2026

Have you ever wondered how those dense jungles and tall trees appear? It began with a leap from the water, a colonization attempt by our plant forebears more than 550 million years ago. But how could these marine organisms have acquired the necessary adaptations for living in such an arid environment? — A recent publication…

Read More Did Aquatic Algae Pave the Way for Lush Forests? New Research Suggests Yes!
Bioinformatics | Machine Learning | News | Paper Summary | RNA-Seq | Sequencing | Tools | Trending

Deciphering the Future with Decipher: A Computational Pipeline for Single-cell Profile-based Context-specific Mechanistic Insights
ByDeotima Chakraborty May 8, 2024October 22, 2026

The development of single-cell profiling methods has transformed our understanding of the cellular and molecular processes underlying disease states and how they respond to therapy. However, existing computer methods cannot objectively recover known and new mechanistic insights at different levels of biological regulation. Here, researchers from the University of Western Australia and The University of…

Read More Deciphering the Future with Decipher: A Computational Pipeline for Single-cell Profile-based Context-specific Mechanistic Insights
AI | Bioinformatics | LLM | News | Paper Summary | Sequencing | Tools | Transcriptomics | Trending

Unveiling Bioinformatics Copilot 1.0: A Cutting-Edge LLM-Driven Solution for Transcriptomic Data Analysis
ByDeotima Chakraborty April 23, 2024October 22, 2026

Single-cell transcriptomics has been generating large-scale information, improving our knowledge of cellular processes across different tissues, and facilitating medication discovery, diagnosis, and prognosis. But sorting through all of this data has proven to be an enormous undertaking that frequently takes weeks or months. The vast amount of data generated—between hundreds of gigabytes and tens of…

Read More Unveiling Bioinformatics Copilot 1.0: A Cutting-Edge LLM-Driven Solution for Transcriptomic Data Analysis
Big Data | Bioinformatics | Cancer | Cloud Computing | Epigenomics | News | NGS | Paper Summary | Sequencing | Tools | Trending

Supercharge Epigenomic Workflows with EAP: A Cloud-Based Platform for Comprehensive and Interactive Analysis of Large ChIP/ATAC-seq Datasets
ByDeotima Chakraborty April 15, 2024October 22, 2026

The significance of comprehending gene expression regulation in tissue development is highlighted by the examination of disease progression through methods such as ChIP-seq and ATAC-seq. On the other hand, the growing volume of data poses computing difficulties, and the dearth of organized tools emphasizes the requirement for effective analysis platforms. Researchers from the Shanghai Institute…

Read More Supercharge Epigenomic Workflows with EAP: A Cloud-Based Platform for Comprehensive and Interactive Analysis of Large ChIP/ATAC-seq Datasets
Bioinformatics | Cell | News | NGS | Paper Summary | RNA-Seq | Sequencing | Tools | Transcriptomics | Trending

Deciphering Ligand-Receptor Signaling Dynamics at Cellular Resolution with CytoSignal: A Breakthrough in Spatial Transcriptomics
ByDeotima Chakraborty March 19, 2024October 22, 2026

A thorough understanding of the cellular connections inside these tissues is being made possible by technologies that use spatial transcriptomic approaches to revolutionize the study of ligand-receptor signaling in tissues. CytoSignal was created by researchers from the University of Texas and the University of Michigan to use spatial transcriptomic data to infer the locations and…

Read More Deciphering Ligand-Receptor Signaling Dynamics at Cellular Resolution with CytoSignal: A Breakthrough in Spatial Transcriptomics
AI | Bioinformatics | Gene Expression | Genomics | News | Paper Summary | Sequencing | Trending

Unraveling Genetic Mysteries with Proformer: A Hybrid Macaron Transformer Model
ByDeotima Chakraborty March 4, 2024October 22, 2026

The ability to comprehensively decode the cis-regulatory logic that controls the expression values is made possible by the revolutionary high-throughput measurement of the cis-regulatory activity of millions of randomly produced promoters. Researchers from the University of Minnesota developed an end-to-end transformer encoder architecture called Performer to predict the expression values from DNA sequences. Proformer is…

Read More Unraveling Genetic Mysteries with Proformer: A Hybrid Macaron Transformer Model
AI | Bioinformatics | Deep Learning | News | Paper Summary | Sequencing | Trending

Unlock the Potential of DeepMod2: A Deep Learning Framework for Precise DNA Methylation Analysis using Oxford Nanopore Sequencing
ByDeotima Chakraborty February 27, 2024October 22, 2026

Reduced representation methylation sequencing for CpG islands or imprinted areas is made possible by Oxford Nanopore sequencing, which offers a distinct advantage over other techniques by identifying DNA methylations from the ionic current signal of individual molecules. Here, scientists present DeepMod2, a thorough deep-learning framework that uses the ionic current signal from Nanopore sequencing to…

Read More Unlock the Potential of DeepMod2: A Deep Learning Framework for Precise DNA Methylation Analysis using Oxford Nanopore Sequencing
Bioinformatics | News | OMICS | Sequencing | Tools | Transcriptomics | Trending

Unveiling Flexiplex: A Versatile and Fast Demultiplexing and Sequence Searching Tool for Omics Data
ByDr. Tamanna Anwar February 23, 2024October 22, 2026

Omics datasets generated by high throughput sequencing contain vast amounts of nucleotide data that must be analyzed to extract meaningful biological insights. A common early step is identifying and extracting specific sequences of interest, like genetic barcodes or variants. Existing tools have limitations for this task, motivating the development of Flexiplex, a new versatile sequence searching…

Read More Unveiling Flexiplex: A Versatile and Fast Demultiplexing and Sequence Searching Tool for Omics Data
Bioinformatics | Infectious Diseases | Metagenomics | News | Paper Summary | Sequencing | Trending

Mount Sinai Researchers Introduce mEnrich-seq: A New Approach to Enriching Taxa of Interest in Microbiomes
ByDeotima Chakraborty January 8, 2024January 8, 2024

In this study, researchers at Icahn School of Medicine developed mEnrich-seq, a method that can enrich taxa of interest from metagenomic DNA before sequencing. This is introduced as existing technologies could only sequence the desired bacterial taxa (pathogens, beneficial microorganisms, or low-abundance taxa), and not the large background of other taxa in a microbiome sample…

Read More Mount Sinai Researchers Introduce mEnrich-seq: A New Approach to Enriching Taxa of Interest in Microbiomes
Bioinformatics | Gene Expression | News | Paper Summary | Sequencing | Trending

ChIP-DIP Multiplexing Method Maps Hundreds of Proteins to DNA Decoding Gene Expression Regulation
ByDeotima Chakraborty December 30, 2023January 4, 2024

The dynamic localization of thousands of unique regulatory proteins to specific DNA sequences regulates the expression of genes. It has been a longstanding objective of molecular biology to comprehend this cell-type specific mechanism. However, it is still difficult because the majority of DNA-protein mapping techniques only look at one protein at a time. A study…

Read More ChIP-DIP Multiplexing Method Maps Hundreds of Proteins to DNA Decoding Gene Expression Regulation
Bioinformatics | CRISPR | Genomics | News | NGS | Paper Summary | Sequencing | Tools | Trending

CReATiNG Synthetic Chromosomes in Yeast Opens New Possibilities in Synthetic Biology
ByDeotima Chakraborty December 25, 2023January 4, 2024

While chromosomal synthesis and cloning are expensive and time-consuming processes, CReATiNG (Cloning, Reprogramming, and Assembling Tiled Natural Genomic DNA), a method introduced by researchers at the University of Southern California, presents a viable substitute. With this technique, sections of natural chromosomes are cloned and put together to create synthetic chromosomes. CReATiNG can change a cell’s…

Read More CReATiNG Synthetic Chromosomes in Yeast Opens New Possibilities in Synthetic Biology
Bioinformatics | News | RNA-Seq | Sequencing | Transcriptomics | Trending

Unlocking the Mysteries of the Mammalian Brain: A Comprehensive Atlas Reveals Surprising Cellular Diversity
ByDr. Tamanna Anwar December 15, 2023October 22, 2026

Scientists from the Broad Institute have made a groundbreaking discovery in the field of neuroscience by mapping the locations of hundreds to thousands of cell types across a mammalian brain. Two research teams at the Broad Institute made this discovery by using spatial transcriptomics to create detailed atlases of the mouse nervous system, paving the…

Read More Unlocking the Mysteries of the Mammalian Brain: A Comprehensive Atlas Reveals Surprising Cellular Diversity
Bioinformatics | News | Precision Medicine | Sequencing | Trending

UK Biobank Releases Unprecedented Genomic Data Trove to Transform Global Health
ByDr. Tamanna Anwar December 2, 2023October 22, 2026

In a monumental milestone, UK Biobank has unveiled open access to incredible whole genome sequencing data for its over half a million participants. This vast genomic resource promises to massively accelerate the diagnosis, treatment, and prevention of diseases worldwide when combined with the study’s expansive health data. Dubbed a “veritable treasure trove” by Professor Sir…

Read More UK Biobank Releases Unprecedented Genomic Data Trove to Transform Global Health
AI | Bioinformatics | Deep Learning | Genomics | News | OMICS | RNA-Seq | Sequencing | Tools | Trending

UCSD’s EUGENe: A New Deep Learning Toolkit to Decode the Regulatory Genome
ByDr. Tamanna Anwar November 22, 2023November 30, 2023

Researchers at the University of California, San Diego, built EUGENe (elucidating the utility of genomic elements with neural nets) – an end-to-end Python toolkit for analyzing genomic sequences using deep learning. EUGENe comprises a collection of modules and sub-packages designed to carry out the essential functions of genomics deep learning. EUGENe aims to enable computational…

Read More UCSD’s EUGENe: A New Deep Learning Toolkit to Decode the Regulatory Genome
News | Paper Summary | Proteomics | Sequencing | Structural Biology | Trending

Demystifying the Genetic Architecture of Proteins through Experimental Models
BySwasti Tyagi November 3, 2023January 24, 2024

A collaborative effort between researchers from the UK, Spain, and Germany utilized experimental methods to explore amino acid sequence spaces and demonstrated that for a decent number of proteins, genetic architecture can be relatively simple. They also noted that models based on artificial intelligence that are conventionally used for biological prediction purposes can be much…

Read More Demystifying the Genetic Architecture of Proteins through Experimental Models
AMR Alert | Big Data | Bioinformatics | Genomics | News | Paper Summary | Sequencing

Meet ggCaller: A Fast and Accurate Solution for Pangenome Annotation and Clustering
ByPrachi Khare October 25, 2023October 25, 2023

Pangenomic annotation is critical for understanding the bacterial genomic variety and depends on recognizing core and accessory genes through gene prediction and clustering. These are vital for characterization and epidemiological examinations. Accessory genes tracked down in unambiguous subsets are related to attributes like antimicrobial opposition, harmfulness, and immunization escape. Current techniques include quality forecast and…

Read More Meet ggCaller: A Fast and Accurate Solution for Pangenome Annotation and Clustering
Bioinformatics | Genomics | Machine Learning | News | Paper Summary | Sequencing | Trending

Mosaic Variant Calling: Benchmarking Approaches and Unveiling Best Practices
BySwasti Tyagi October 23, 2023October 22, 2023

Scientists from Yonsei University College of Medicine, Republic of Korea, have developed a new benchmark for evaluating mosaic variant calling methods, which are used to detect genetic mutations in individuals. The benchmark will help researchers select the most suitable calling algorithms for their studies and guide developers in improving the accuracy of these methods. The…

Read More Mosaic Variant Calling: Benchmarking Approaches and Unveiling Best Practices
AI | Bioinformatics | Cancer | Covid-19 News | Drug Discovery | Infectious Diseases | LLM | News | Paper Summary | Sequencing | Tools | Trending | Virus

CodonBERT: A New Large Language Model Could Help Design Optimized mRNA Vaccines and Therapeutics
BySwasti Tyagi September 19, 2023October 22, 2026

A team of researchers at Digital R&D, Sanofi, USA, developed CodonBERT, a transformer-based large language model that is used for performing tasks related to mRNA protein prediction and analysis. It is trained by using codons as its input; 10 million sequences from a diverse range of organisms have been used to facilitate this. It selects…

Read More CodonBERT: A New Large Language Model Could Help Design Optimized mRNA Vaccines and Therapeutics
Bioinformatics | Cell | Genomics | LLM | News | Paper Summary | Sequencing | Transcriptomics | Trending

Large Language Models Meet Single Cell Transcriptomics: Unlocking Biological Insights with Cell2Sentence
ByPrachi Khare September 18, 2023November 29, 2023

Large language models, such as GPT (Generative Pre-trained Transformer), have showcased remarkable proficiency in various natural language processing tasks. Their ability to understand and generate text akin to human speech has paved the way for their widespread application across diverse domains. However, integrating these language models into specialized disciplines like biology has been challenging. This…

Read More Large Language Models Meet Single Cell Transcriptomics: Unlocking Biological Insights with Cell2Sentence
Bioinformatics | Cancer | Cancer Research | Cell | News | Paper Summary | RNA-Seq | Sequencing | Systems Biology

Meet FateMap: A Barcoding Approach to Decode Why Certain Cells Resist Anti-Cancer Therapies
BySwasti Tyagi August 29, 2023December 4, 2023

A collaborative research effort led by scientists and engineers at the University of Pennsylvania and Northwestern University led to the development of FateMap, a framework that combines DNA barcoding, single-cell RNA sequencing (scRNA-seq), and computational analysis to study the ‘fate’ or outcomes after exposing cancer cells to therapeutic drugs. It has been found that even…

Read More Meet FateMap: A Barcoding Approach to Decode Why Certain Cells Resist Anti-Cancer Therapies
Bioinformatics | Genomics | News | Paper Summary | Sequencing | Trending

Scientists Assemble the First Complete Human Y Chromosome Sequence: A Milestone in Genomics Research
ByNeegar Naushaba Iqbal August 26, 2023August 29, 2023

The sequencing and assembly of the human Y chromosome have been challenging due to its intricate repeat structure, which encompasses lengthy palindromes, tandem repeats, and segmental duplications. The existing GRCh38 reference sequence lacks over half of the Y chromosome’s content, leaving it as the final unfinished human chromosome. Addressing these limitations, the Telomere-to-Telomere (T2T) consortium…

Read More Scientists Assemble the First Complete Human Y Chromosome Sequence: A Milestone in Genomics Research
AI | Bioinformatics | Cancer | GWAS | Machine Learning | News | Paper Summary | Sequencing | Trending

Beyond Biopsies: Single-Molecule Cell-Free DNA Profiling Fuels Non-Invasive Cancer Screening and Detection
ByNeegar Naushaba Iqbal July 30, 2023July 30, 2023

A new ray of hope for non-invasive cancer detection has emerged. A machine learning algorithm called GEMINI, created by John Hopkins University and Boston University researchers, can effectively diagnose cancer patients using CT scans, even in the early stages (stages I and II), without intrusive treatments like biopsies. This model focuses on the DNA changes…

Read More Beyond Biopsies: Single-Molecule Cell-Free DNA Profiling Fuels Non-Invasive Cancer Screening and Detection
Big Data | Bioinformatics | News | NGS | Paper Summary | RNA-Seq | Sequencing | Tools | Trending

Matching RNA Sequencing Alignment Data to Genotypes Made Easy with RNA Strain-Match
ByNeegar Naushaba Iqbal July 20, 2023July 20, 2023

Researchers from the Jackson Laboratory for Mammalian Genetics, USA, have built RNA Strain-Match, a quality control tool helpful in matching RNA data to their corresponding genotypes. A significant possibility exists that some samples will be switched or mislabeled during large-scale next-generation sequencing (NGS). Therefore, it is beneficial to have tools or techniques present within the…

Read More Matching RNA Sequencing Alignment Data to Genotypes Made Easy with RNA Strain-Match
AI | Big Data | Bioinformatics | Computational Models | Genomics | News | Paper Summary | Sequencing | Trending

ChatGPT meets DNA: DNAGPT, The Ultimate Tool for Multitasking DNA Sequence Analysis!
ByNeegar Naushaba Iqbal July 18, 2023July 18, 2023

Motivated by the success of the GPT (Generative Pre-trained Transformer) model, researchers from the Southern University of Science and Technology, Tencent AI Lab, Shenzhen, China, and the City University of Hong Kong have developed DNAGPT, a generalized foundation model capable of simultaneously processing multiple DNA sequences from various species. Its unique token design allows users…

Read More ChatGPT meets DNA: DNAGPT, The Ultimate Tool for Multitasking DNA Sequence Analysis!
Algorithm | Bioinformatics | Deep Learning | News | NGS | Paper Summary | Sequencing | Tools | Trending

Meet Mapinsights: A New Toolkit for Impeccable Quality Control of High-Throughput Sequencing Data
ByNeegar Naushaba Iqbal July 14, 2023November 24, 2023

High-Throughput Sequencing (HTS) has drastically transformed the world of genomics by allowing rapid and accurate detection of genomic variations at the level of individual base pairs. However, the presence of technical artifacts (hidden non-random error patterns affecting the accuracy of variant identification) degrades HTS data quality. Scientists from the National Institute of Biomedical Genomics, India,…

Read More Meet Mapinsights: A New Toolkit for Impeccable Quality Control of High-Throughput Sequencing Data
Agriculture | Bioinformatics | Education | News | Sequencing | Trending

Uncovering the Genetic Blueprint of Cotton: Scientists Sequence the Cotton Genome
ByDr. Tamanna Anwar June 26, 2023June 26, 2023

Cotton, the primary source of natural fiber worldwide, has played a significant role in the textile industry. While several cotton species exist, only four are suitable for textile production. DePaul University computer scientists employed a bioinformatics approach to reconstruct the genome of a significant cotton species, specifically the African domesticated Gossypium herbaceum cultivar Wagad. This breakthrough discovery…

Read More Uncovering the Genetic Blueprint of Cotton: Scientists Sequence the Cotton Genome
Bioinformatics | Cell | Genomics | News | NGS | Sequencing | Trending

Discovering Genome-Wide Chromatin Contacts: Multiplex-GAM vs. Hi-C Showdown!
ByDr. Tamanna Anwar June 22, 2023June 22, 2023

Chromatin conformation capture techniques have revolutionized our understanding of genome organization and its impact on gene regulation. Hi-C, the gold standard method for investigating chromatin contacts, has shed light on the three-dimensional organization of the genome. Nonetheless, new developments in genomic technology have opened the door for new strategies that offer a more thorough understanding…

Read More Discovering Genome-Wide Chromatin Contacts: Multiplex-GAM vs. Hi-C Showdown!
Algorithm | Bioinformatics | Genomics | News | Paper Summary | Sequencing | Trending

Meet OrthoVenn3: A Powerful, Web-based Platform for Analyzing and Visualizing Orthologous Data Across Genomes
BySipra Das May 5, 2023May 7, 2023

Recent developments in comparative genomics studies, along with the availability of cutting-edge computational tools, have revived the study of evolutionary biology and genetics in a new way. Existing computational tools can efficiently interpret orthologous clusters of genes and determine phylogenetic relationships among species. The recently upgraded release of the Web-based program OrthoVenn, called OrthoVenn3, with…

Read More Meet OrthoVenn3: A Powerful, Web-based Platform for Analyzing and Visualizing Orthologous Data Across Genomes
AI | Bioinformatics | News | NGS | OMICS | Paper Summary | RNA-Seq | Sequencing | Trending

Meet scGPT: A Cutting-edge Foundation Model for Single-cell Multiomics using Generative AI
ByBanhita Maitra May 4, 2023November 23, 2023

Scientists from the University of Toronto, Canada, have developed a foundation model for single-cell analysis, scGPT, by generative pre-training on over ten million cells. The generative pre-trained transformer for single-cell analysis is capable of capturing meaningful and crucial biological insights at the gene and cellular levels. The foundation model can be finetuned for numerous downstream…

Read More Meet scGPT: A Cutting-edge Foundation Model for Single-cell Multiomics using Generative AI
Bioinformatics | Disease Diagnosis | News | Paper Summary | RNA-Seq | Sequencing | Trending

Pediatric Rare Disease Diagnosis using Trio RNA Sequencing
BySipra Das April 20, 2023April 20, 2023

The RNA-Seq (RNA sequencing) program at The Hospital for Sick Children (SickKids) is focused on developing new tools for Pediatric Rare Disease research. Their clinically approved RNA sequencing platform combines RNA and Genome sequencing methods to create personalized medicine. The study also reviewed the applicability of Trio RNA sequencing methods in identifying mutations causing inherited diseases in…

Read More Pediatric Rare Disease Diagnosis using Trio RNA Sequencing
Bioinformatics | Cancer Research | Drug Discovery | News | Paper Summary | Sequencing | Trending

Efficiently Identifying Bispecific Antibodies using High Throughput Single-cell BsAb Discovery Pipeline
ByDiyan Jain April 11, 2023January 18, 2024

Bispecific antibodies (BsAbs) are an emerging type of immunotherapy and have great potential to treat various diseases. Recently, researchers have developed a novel single-cell platform that can efficiently discover rare BsAb clones with unique and desirable properties that would otherwise be close to impossible to discover using other existing conventional low-throughput, biased, and trial-and-error methods….

Read More Efficiently Identifying Bispecific Antibodies using High Throughput Single-cell BsAb Discovery Pipeline
Bioinformatics | Deep Learning | News | OMICS | Paper Summary | Sequencing | Tools | Trending

Meet DeepBIO: An Automated Deep Learning Platform for High-Throughput Functional Analysis of Biological Sequences
ByBanhita Maitra February 26, 2023February 26, 2023

Scientists from China have developed DeepBIO, an automated and interpretable deep learning platform for high-throughput biological sequence functional analysis. The first-of-its-kind platform enables researchers to develop new deep-learning architectures addressing particular biological questions. For any given biological sequence data, DeepBIO offers 42 state-of-the-art deep learning algorithms for model training, comparison, optimization, and evaluation in a…

Read More Meet DeepBIO: An Automated Deep Learning Platform for High-Throughput Functional Analysis of Biological Sequences
Algorithm | Bioinformatics | Genomics | News | OMICS | Paper Summary | Sequencing | Trending

NHGRI’s Verkko Algorithm: An Advancement in Genome Assembly with Notable Limitations
BySejal Saxena February 25, 2023February 24, 2023

Substantial progress has been made in assembling the first complete human genome sequence by the Telomere-to-Telomere consortium. However, complex repetitions in diploid genomes are still difficult to decode. Using lengthy, accurate reads and haplotype-specific markers, the Verkko pipeline is an automated method for assembling diploid genomes with high precision. The construction of pangenomes and chromosome-scale…

Read More NHGRI’s Verkko Algorithm: An Advancement in Genome Assembly with Notable Limitations
Bioinformatics | News | NGS | Paper Summary | RNA-Seq | Sequencing | Transcriptomics | Trending

Single-Cell RNA Sequencing: State-of-the-Art Technology and Future Prospects
ByBanhita Maitra February 24, 2023February 24, 2023

Single-cell RNA sequencing (scRNA-seq) has proved to be a powerful tool for deciphering the entire repertoire of transcripts in a single cell. Traditional sequencing techniques detect averaged transcript levels for cell populations. The emerging technology of scRNA-seq enables the classification of cell subpopulation and cell heterogeneity. The authors of the review focus on the recent…

Read More Single-Cell RNA Sequencing: State-of-the-Art Technology and Future Prospects
Bioinformatics | Genomics | Machine Learning | News | Paper Summary | Sequencing | Tools | Trending

Meet MinsePIE: A ML Tool to Predict Successful Insertion of Gene-edited DNA Sequences in the Genome of a Cell
ByBanhita Maitra February 20, 2023February 19, 2023

Scientists from the Wellcome Sanger Institute, Hinxton, UK, and the University of Tartu, Estonia, have developed a machine learning-based algorithm, MinsePIE, to predict prime editing insertion efficiencies. The authors performed a comprehensive analysis of prime editing efficiencies by designing a library of 3604 sequences of varying lengths and measuring the frequency of insertion into four…

Read More Meet MinsePIE: A ML Tool to Predict Successful Insertion of Gene-edited DNA Sequences in the Genome of a Cell
Antibiotic Resistance | Bioinformatics | Infectious Diseases | News | Precision Medicine | Sequencing | Trending | Virus

Local Creek Holds Secret to Fighting Deadly Infections: Newly Discovered Virus Kills Resistant Bacteria
ByDr. Tamanna Anwar February 18, 2023February 19, 2023

Scientists from the University of Southern Denmark have made an interesting discovery that may help in the fight against antibiotic-resistant bacteria. The research team has identified five novel virus species that were not known earlier to the scientific community. The finding may offer new treatment strategies against deadly infections as the virus species discovered can…

Read More Local Creek Holds Secret to Fighting Deadly Infections: Newly Discovered Virus Kills Resistant Bacteria
Bioinformatics | Database | Drug Discovery | GWAS | News | NGS | Paper Summary | Precision Medicine | Sequencing | Trending

AGORA2: The Key to Personalized Medicine through Genome-wide Metabolic Reconstruction of Human Microbes
BySejal Saxena February 6, 2023February 6, 2023

The digestive system is home to trillions of bacteria, which are very different in each person based on their gender, age, race, lifestyle, and health. For precision medicine to include microbial metabolism, computer models would have to be expandable and able to resolve strains and molecules. This study introduces us to AGORA2 – assembly of…

Read More AGORA2: The Key to Personalized Medicine through Genome-wide Metabolic Reconstruction of Human Microbes
Bioinformatics | Drug Discovery | Genomics | News | NGS | Sequencing | Trending

Discovering the Secrets of Drug-Targeted Genome Interactions with a New DNA Sequencing Method “Chem-map”
ByDr. Tamanna Anwar January 24, 2023January 24, 2023

Scientists from the University of Cambridge have introduced a cutting-edge DNA sequencing method that can precisely pinpoint the location and mechanism of small molecule drugs interacting with the targeted genome. The novel technique has the potential to provide valuable insights into the drug development process and increase our understanding of the complex interactions between drugs…

Read More Discovering the Secrets of Drug-Targeted Genome Interactions with a New DNA Sequencing Method “Chem-map”
Algorithm | Bioinformatics | Data Science | News | NGS | RNA-Seq | Sequencing | Tools | Transcriptomics | Trending

Meet “Espresso”: The Solution for Accurate Quantification of Transcript Isoforms in Error-Prone RNA-Seq Data
ByDr. Tamanna Anwar January 22, 2023January 22, 2023

The Children’s Hospital of Philadelphia (CHOP) scientists have created ESPRESSO, a new computational tool for analyzing RNA-seq data. ESPRESSO aims to improve the detection and quantification of transcript isoforms, which are variations of a gene that can serve different functions. ESPRESSO is particularly useful when dealing with long-read RNA-seq data, which can be prone to…

Read More Meet “Espresso”: The Solution for Accurate Quantification of Transcript Isoforms in Error-Prone RNA-Seq Data
Bioinformatics | Cancer Research | Machine Learning | News | NGS | OMICS | Sequencing | Trending

Unraveling the Mechanics of DNA: Scientists Decrypt the ‘Mechanical Code’
ByDr. Tamanna Anwar January 9, 2023January 20, 2023

The mechanical properties of DNA are affected by various processes, including local sequence and epigenetic modifications. It has been challenging to understand the relationship between these modifications and DNA’s mechanical properties because of a lack of efficient experimental methods. Durham University researchers, in collaboration with researchers from Johns Hopkins University, Barcelona Institute of Science and…

Read More Unraveling the Mechanics of DNA: Scientists Decrypt the ‘Mechanical Code’
Bioinformatics | Chronic Diseases | Genomics | GWAS | Health | News | OMICS | Paper Summary | Sequencing | Trending

Exploring the Intersection of Genomics and Phenomics in the Study of Body Mass Index Reveals a Complex Disease Network
ByRiya Vishwakarma January 8, 2023January 20, 2023

The relationship between Body Mass Index (BMI) and several health issues that have an influence on morbidity and mortality has been the focus of research by epidemiologists and scientists with roots in China and the USA. The possibility to further our understanding of the breadth and depth of illnesses connected to obesity exists in the…

Read More Exploring the Intersection of Genomics and Phenomics in the Study of Body Mass Index Reveals a Complex Disease Network
Big Data | Bioinformatics | Genomics | News | NGS | OMICS | Sequencing | Tools | Trending

Discover the Power of RGT: A Toolbox for Analyzing High Throughput Regulatory Genomics Data
ByDr. Tamanna Anwar January 7, 2023December 2, 2023

The Bioinformatics and Genomics Group at the University of Barcelona has developed “RGT” (Regulatory Genomics Toolbox), a powerful tool for the integrative analysis of high throughput regulatory genomics data. RGT is a comprehensive and user-friendly software package that allows researchers to analyze and interpret complex data sets. The integration and analysis of high-throughput regulatory genomics…

Read More Discover the Power of RGT: A Toolbox for Analyzing High Throughput Regulatory Genomics Data
Algorithm | Bioinformatics | Biomedical Engineering | Cancer Research | Drug Discovery | Featured | Genomics | News | OMICS | Sequencing | Structural Biology | Tools | Trending

Top 10 Bioinformatics Breakthroughs of 2022!
ByCatherene Tomy December 27, 2022January 11, 2023

The field of bioinformatics has seen numerous exciting breakthroughs in the year 2022 that have transformed the landscape of biological research. Many important discoveries have advanced our understanding of complex biological processes and have led to new treatments and therapies for diseases. In this article, we will explore the top 10 bioinformatics discoveries of the…

Read More Top 10 Bioinformatics Breakthroughs of 2022!

Cookie	Duration	Description
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Sequencing

Meet ggCaller: A Fast and Accurate Solution for Pangenome Annotation and Clustering

Meet FateMap: A Barcoding Approach to Decode Why Certain Cells Resist Anti-Cancer Therapies

Training

Services

Resources

Company