Sequencing

Bioinformatics | News | NGS | RNA-Seq | Sequencing | Trending

Unveiling the Hidden Messages of Photosynthesis: Deciphering the Language of Plant Life
ByDr. Tamanna Anwar December 22, 2022December 21, 2022

Researchers at UC Riverside have made a breakthrough in understanding the signals that plants use to initiate photosynthesis, the process of converting sunlight into sugars. These signals have long been a mystery to scientists. The team’s findings offer new insights into how photosynthesis is regulated in plants. It has been known for decades that the…

Read More Unveiling the Hidden Messages of Photosynthesis: Deciphering the Language of Plant Life
AI | Bioinformatics | Education | Facts | Learn Bioinformatics | Machine Learning | News | NGS | OMICS | Sequencing | Trending

MACHINE LEARNING FOR BIOMARKER DISCOVERY USING NGS DATA
ByCatherene Tomy December 21, 2022December 5, 2023

In this article, we will be exploring how machine learning (ML) techniques can be used to identify and analyze biomarkers from next generation sequencing (NGS) data. Biomarkers are specific biological molecules or characteristics that can be used to identify the presence or severity of a particular disease or condition. They play a crucial role in…

Read More MACHINE LEARNING FOR BIOMARKER DISCOVERY USING NGS DATA
Bioinformatics | Genomics | News | Paper Summary | RNA-Seq | Sequencing | Trending

Annotate_My_Genomes: A Simple Pipeline for Improved Genome Annotation and Neglected Gene Discovery Through Hybrid RNA Sequencing
ByRiya Vishwakarma December 19, 2022December 19, 2022

A simple genome-guided transcriptome annotation pipeline created by researchers from Chile and the University of Manitoba in Winnipeg, Manitoba, Canada, that takes compiled transcripts from hybrid sequencing information as input and recognizes coding and long non-coding RNAs by integrating a number of bioinformatic techniques, including gene reconciliation with earlier annotations in GTF format. The expansion…

Read More Annotate_My_Genomes: A Simple Pipeline for Improved Genome Annotation and Neglected Gene Discovery Through Hybrid RNA Sequencing
Bioinformatics | Metabolomics | News | NGS | OMICS | Sequencing | Trending

A Multi-Omics Approach to Earth’s Microbiomes Project Demonstrates Microbial and Metabolite Diversity
ByRiya Vishwakarma December 5, 2022December 5, 2022

Contrasting sharply with the little knowledge of the microbial world’s underlying structure is the rising awareness of its significance and variety. Despite recent developments in DNA sequencing, the establishment of general conclusions regarding microbial life on Earth is hampered by the absence of standardized techniques and shared analytical frameworks. Researchers at the University of California San…

Read More A Multi-Omics Approach to Earth’s Microbiomes Project Demonstrates Microbial and Metabolite Diversity
Bioinformatics | News | NGS | Paper Summary | RNA-Seq | Sequencing | Tools | Trending

RNAlysis: a Gateway into RNA Sequencing Data Analysis for Less Computer-savvy Researchers
ByRiya Vishwakarma November 29, 2022November 29, 2022

Qualitative data analysis, understanding patterns, finding possible targets/candidates, and intuitively displaying the results are among the crucially difficult aspects of next-generation sequencing experiments. These challenges are even more difficult for researchers who are not accustomed to writing computer code because the bulk of the analysis tools accessible demand programming knowledge. A customizable Python-based analysis program…

Read More RNAlysis: a Gateway into RNA Sequencing Data Analysis for Less Computer-savvy Researchers
Bioinformatics | Genomics | News | NGS | Paper Summary | Sequencing | Trending

Scientists Unveil High-Resolution Reference Genome of Nile Rat – A Promising Animal Model for Diabetes Research
ByShwetha S November 13, 2022November 13, 2022

A research team led by Yury V. Bukhman from the Morgridge Institute for Research has put forth a reference genome with haplotype-resolved assemblies and gene annotations deciphering the Nile Rat (Arvicanthis niloticus) as a carbohydrate-sensitive model for diabetes research. An animal model is a living, genetically engineered organism used for research and investigating human diseases….

Read More Scientists Unveil High-Resolution Reference Genome of Nile Rat – A Promising Animal Model for Diabetes Research
Bioinformatics | Cancer Research | Genomics | News | NGS | Paper Summary | RNA-Seq | Sequencing | Trending

A Novel CRISPR-based Technique ‘MACHETE’ Investigates Copy Number Alterations in Cancer Genome
ByMahi Sharma November 12, 2022January 10, 2024

The post-doctoral researchers from Memorial Sloan Kettering Cancer Centre (MSK) developed an upfront and coherent way to study copy number alterations (CNA) deletions in the laboratory using the pancreatic and melanoma cancer mouse models. The CRISPR-based method revealed clinically relevant observations into the multifaceted nature of 9p21.3 ommissions that contribute to up to 15% of…

Read More A Novel CRISPR-based Technique ‘MACHETE’ Investigates Copy Number Alterations in Cancer Genome
Big Data | Bioinformatics | Cancer Research | Drug Discovery | News | Paper Summary | Precision Medicine | RNA-Seq | Sequencing | Trending | Virus

Large-scale Proteo-genomic Profiling of Virus-associated Liver Cancer Unveils Potential Subtypes and Therapeutic Targets
ByMahi Sharma November 9, 2022October 22, 2026

A large percentage of the global population is shown to have been affected by different types of cancer and increased mortality. Hepatocellular carcinoma, or primary liver cancer is one the life-threatening disease and the fastest-growing cancer type in the United States. A recent study conducted by Hidewaki Nakagawa et al. leveraged the proteomic profiling of…

Read More Large-scale Proteo-genomic Profiling of Virus-associated Liver Cancer Unveils Potential Subtypes and Therapeutic Targets
Bioinformatics | Computational Models | Genomics | Metagenomics | News | NGS | Paper Summary | Sequencing | Tools | Trending

Researchers Develop a Computational Tool ‘CAMMiQ’ for Strain Level Microbial Detection and Quantification Using High Throughput Sequencing Data
ByMahi Sharma November 5, 2022November 5, 2022

A recent study led under the supervision of Cenk Sahinalp et al. and conducted jointly at the National Institute of Health, UCSD, and Indiana University introduced an optimized framework for strain-level microbial identification. The team has provided a comparative approach with reference to other taxonomic classifiers and embedded results with higher sensitivity and specificity. Introduction…

Read More Researchers Develop a Computational Tool ‘CAMMiQ’ for Strain Level Microbial Detection and Quantification Using High Throughput Sequencing Data
Bioinformatics | News | Paper Summary | Sequencing | Trending

Genomic Insights into the Physiology of an Iconic Unculturable Rumen Bacterium ‘Quinella’
ByMahi Sharma October 23, 2022October 23, 2022

The iconic bacterial genus from sheep rumen ‘Quinella’ has been the center of bacterial taxonomy for various reasons. The research group from Massey University, New Zealand, and the National University of Singapore have deciphered the genomic insights using metagenomic sequencing. The analysis provided observations into taxonomic diversity and assess genetic data for the physiological understanding…

Read More Genomic Insights into the Physiology of an Iconic Unculturable Rumen Bacterium ‘Quinella’
Bioinformatics | Data Science | News | NGS | OMICS | Paper Summary | RNA-Seq | Sequencing | Trending

In a Benchmark Study, Scientists Investigated the Integration of Temporal Sequencing Modalities for Trajectory Inference and Disease Prediction
ByMahi Sharma October 2, 2022October 1, 2022

Recent advancements in trajectory inferences have unfolded a new side of bioinformatics, i.e., single-cell analysis. The research group from the University of Northern Carolina School of Medicine benchmark study addressed gaps in capturing temporal changes in a single-cell state. Interpretation of dynamic phenotypes using ten datasets spanning different biological environments at three distinct temporal stages….

Read More In a Benchmark Study, Scientists Investigated the Integration of Temporal Sequencing Modalities for Trajectory Inference and Disease Prediction
Bioinformatics | Metagenomics | News | Paper Summary | Sequencing | Tools | Trending

iNAP: An Integrated Network Analysis Pipeline for Microbiome Studies in Complex Ecosystems
ByMahi Sharma September 28, 2022September 28, 2022

Microbial network analysis is an acceptable approach to investigating microbiome and metagenomic datasets and finding insights into a complex ecosystem. Ye Deng et al. introduced an integrated pipeline, iNAP, for network construction and visualization to help researchers understand microbial ecology without prior knowledge of bioinformatics or statistical programming skills. Understanding and deducing information from microbial…

Read More iNAP: An Integrated Network Analysis Pipeline for Microbiome Studies in Complex Ecosystems
Bioinformatics | Cancer Research | News | NGS | Paper Summary | Sequencing | Trending

Mathematical Modeling Bridges Chromatin Architecture with Potential in Genome Medicine
ByMahi Sharma September 26, 2022September 26, 2022

Scientists from the University of Michigan employed hypergraph theory, utilizing long sequence reads to map genome-wide multi-ways to identify chromatin architecture within the human genome. Understanding how a cell is organized could help biologists develop treatments that halt cancer and other diseases. The kinetics of high-order chromatin composition is known to play a role in…

Read More Mathematical Modeling Bridges Chromatin Architecture with Potential in Genome Medicine
Bioinformatics | Metagenomics | News | NGS | Paper Summary | Sequencing | Trending

Microbiome Data Analysis using Differential Abundance Methods – A Benchmark Study
BySrishti Sharma September 22, 2022September 22, 2022

In order to perform an extensive benchmarking of the known tools for differential abundance analysis, the researchers from the University of Padova used a simulator of microbiome data to create a simulation framework based on microbiome data. This is the first step towards the development of a robust, reliable, and fair simulation framework that will…

Read More Microbiome Data Analysis using Differential Abundance Methods – A Benchmark Study
Bioinformatics | News | Paper Summary | RNA-Seq | Sequencing | Trending

Scientists Construct a Single-cell Level Cross-species Cell Landscape by Integrating Over 2.6 Million Single Cells
BySrishti Sharma September 9, 2022September 9, 2022

Life is based on individual cells. Landscape dynamics across species have not been compared despite extensive efforts to characterize cellular heterogeneity. A large number of cell landscapes were mapped for mice, zebrafish, and Drosophila at multiple life stages using single-cell RNA sequencing (scRNA-seq). With over 2.6 million single cells integrated, the construction of a cross-species…

Read More Scientists Construct a Single-cell Level Cross-species Cell Landscape by Integrating Over 2.6 Million Single Cells
Facts | Sequencing

What is DNA Sequencing?
ByDr. Tamanna Anwar September 4, 2022September 4, 2022

DNA sequencing is the process of determining the order of nucleotides (the building blocks of DNA) A, T, G, and C in a strand of DNA. In humans, the sequence of the base pairs determines our genetic code, which dictates how we look and act. The human genome contains approximately 3.2 billion bases arranged in…

Read More What is DNA Sequencing?
Bioinformatics | Genomics | News | NGS | OMICS | Sequencing | Trending

Scientists from Seven Bridges Genomics Show how Utilizing Population-Specific Genome Graphs Improves High-throughput Sequencing Data Analysis
ByTanveen Kaur August 10, 2022August 11, 2022

Seven Bridges Genomics, USA, scientists demonstrate an approach for iteratively augmenting tailored genome graphs for targeted populations on whole-genome samples of African ancestry. Due to the current human genome reference’s inadequacy in representing the varied genetic information from various human populations and its incapability to maintain the same level of accuracy for non-European ancestries, graph-based…

Read More Scientists from Seven Bridges Genomics Show how Utilizing Population-Specific Genome Graphs Improves High-throughput Sequencing Data Analysis
AMR Alert | Antibiotic Resistance | Bioinformatics | Infectious Diseases | News | RNA-Seq | Sequencing | Trending

An ‘Elegant’ Mechanism of Antibiotic Resistance in Golden Staph Revealed by a New Tool
ByDr. Tamanna Anwar July 27, 2022July 27, 2022

Scientists from the University of New South Wales have discovered a complex system for adaptability in Staphylococcus aureus that has led to the identification and characterization of multi-drug resistance mechanisms as well as the development of new lines of antibiotic defense. The remedy for methicillin-resistant S. aureus infections depends on the effectiveness of the last-line antibiotics such as vancomycin….

Read More An ‘Elegant’ Mechanism of Antibiotic Resistance in Golden Staph Revealed by a New Tool
Bioinformatics | Database | Genomics | News | NGS | Sequencing | Trending

The UK Biobank Released the Largest Set of Whole Genome Sequences Together with Population Genetics and Trait Association Studies for 150,119 Individuals
ByTanveen Kaur July 26, 2022November 11, 2022

Scientists discuss the study of 150,119 people’s whole genomes from the UK Biobank, which is a group of high-quality variants that includes 58,707,036 indels and 585,040,410 single-nucleotide polymorphisms, or 7.0 percent of all potential single-nucleotide polymorphisms in humans. A thorough and trustworthy characterization of both sequences and phenotypic variation is necessary to gain a thorough…

Read More The UK Biobank Released the Largest Set of Whole Genome Sequences Together with Population Genetics and Trait Association Studies for 150,119 Individuals
Bioinformatics | Corona Virus | COVID-19 | Covid-19 News | Genomics | News | NGS | Paper Summary | Sequencing | Trending

Scientists Devised a Bioinformatics Method ‘COJAC’ for Early Detection and Surveillance of SARS-CoV-2 Genomic Variants in Wastewater
ByTanveen Kaur July 21, 2022November 11, 2022

Using read pairs with several SARS-CoV-2 variant-specific signature mutations as a reliable signal of low-frequency variants, scientists develop the bioinformatics technique known as COJAC (Co-Occurrence adjusted Analysis and Calling). The genomic sequencing, in conjunction with COJAC, can offer population-level estimates of the prevalence and fitness of emerging variants from wastewater samples earlier and on the basis…

Read More Scientists Devised a Bioinformatics Method ‘COJAC’ for Early Detection and Surveillance of SARS-CoV-2 Genomic Variants in Wastewater
Bioinformatics | Cancer Research | News | NGS | Sequencing | Trending

NT-seq – A New Sequencing Technique for Genome-Wide Mapping of Different Types of DNA Methylation
ByDr. Tamanna Anwar July 3, 2022July 3, 2022

Baylor College of Medicine researchers introduce a new sequencing technique ‘NT-seq’ for simultaneously mapping all three forms of DNA methylation. All known methylation motifs in Escherichia coli and Helicobacter pylori genomes were reliably detected by NT-seq, which may also be utilized to find de novo methylation motifs. NT-seq offers a quick and effective way for genome-wide mapping of different…

Read More NT-seq – A New Sequencing Technique for Genome-Wide Mapping of Different Types of DNA Methylation
Bioinformatics | Infectious Diseases | News | NGS | Sequencing | Tools | Trending

Computer Scientists from Rice University Develop a Software ‘Emu’ for Accurate Microbial Community Profiling
ByDr. Tamanna Anwar July 1, 2022July 1, 2022

Emu, an approach that uses an expectation-maximization algorithm to generate taxonomic abundance profiles from full-length 16S rRNA reads profiles microbial populations using common genes. According to results generated from simulated datasets and mock communities, Emu is capable of accurate microbial community profiling while obtaining fewer false positives and false negatives than alternative approaches, When determining…

Read More Computer Scientists from Rice University Develop a Software ‘Emu’ for Accurate Microbial Community Profiling
Bioinformatics | News | NGS | RNA-Seq | Sequencing | Trending

TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition
ByDr. Tamanna Anwar June 28, 2022June 28, 2022

The emergence of single-cell RNA sequencing (scRNA-seq) has now made it possible to analyze the internal workings of hundreds of cells at once, revolutionizing biology and medicine. However, the limitations of scRNA-seq methods include the potential for inaccurate cell composition analysis and the ineffectiveness of complementary DNA (cDNA) amplification, which is the process by which…

Read More TAS-Seq – A New Sensitive, and Powerful Single-Cell RNA Sequencing Technique Surpasses Competition
Bioinformatics | Data Science | Featured | Genomics | News | NGS | Sequencing | Tools | Trending

Scientists Use CRISPR Technology and Perturb-seq to Map Every Human Gene to its Function
ByDr. Tamanna Anwar June 11, 2022June 18, 2022

Scientists from Whitehead Institute and collaborators used Perturb-seq, a single-cell sequencing technology, to link every expressed gene in the human genome to its function in the cell, offering a free resource for other researchers that can be accessed via the internet. The Human Genome Project was a huge undertaking that aimed to sequence every single…

Read More Scientists Use CRISPR Technology and Perturb-seq to Map Every Human Gene to its Function
Bioinformatics | Genomics | News | Sequencing | Trending | Virus

First Draft of Monkeypox Virus Genome Sequenced from Current Outbreak Patient
ByDr. Tamanna Anwar May 24, 2022June 18, 2022

In a quest to understand why the monkeypox virus, which is a less lethal relative of smallpox, has infected so many people around the world, the scientists have sequenced its genome. The first draft genome sequence of the monkeypox virus was released recently, derived from a swab of a confirmed case of the current outbreak….

Read More First Draft of Monkeypox Virus Genome Sequenced from Current Outbreak Patient
Bioinformatics | News | NGS | RNA-Seq | Sequencing | Trending

Resistance Genes Identified can Predict Response to Arthritis Treatment and Lays Foundation for Future Drug Development
ByDr. Tamanna Anwar May 22, 2022June 18, 2022

Researchers from the Queen Mary University of London have shown that molecular profiling of diseased joint tissue can significantly impact whether specific medication treatments will work to treat rheumatoid arthritis (RA) patients. The researchers also discovered certain genes linked to resistance to most available medications, a condition known as refractory illness, which could lead to…

Read More Resistance Genes Identified can Predict Response to Arthritis Treatment and Lays Foundation for Future Drug Development
Algorithm | Bioinformatics | Genomics | Machine Learning | News | NGS | Sequencing | Tools | Trending

‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up DNA Sequencing
ByDr. Tamanna Anwar May 21, 2022June 18, 2022

The algorithm is the first full-fledged machine learning-based short read alignment algorithm to speed up DNA sequencing, that efficiently uses learned indices to solve the exact match search issue for efficient seeding. The human genome is made up of a whole set of DNA that is around 6.4 billion letters long. Reading the entire genome…

Read More ‘BWA-MEME’ – Machine Learning-Based Short Read Alignment Algorithm to Speed up DNA Sequencing
AMR Alert | Antibiotic Resistance | Bioinformatics | Metagenomics | News | NGS | Sequencing | Trending

Impact of Antibiotics on the Evolution of Gut Microbiome and Antimicrobial Resistance
ByDr. Tamanna Anwar May 13, 2022June 18, 2022

Following a single antibiotic course, the researchers discover how gut commensals acquire antimicrobial resistance genes (ARGs). According to the researchers, a single round of antibiotics may be enough to drive ARG acquisition and occurrence in gut commensals throughout the duration of a mammalian lifetime. Antibiotics are frequently used to treat infections and ensure surgical treatments…

Read More Impact of Antibiotics on the Evolution of Gut Microbiome and Antimicrobial Resistance
Bioinformatics | News | NGS | RNA-Seq | Sequencing | Transcriptomics | Trending

Single Cell RNA Sequencing Determines 16 Distinct Cell Populations in a Key Brain Area for Substance Use Disorders
ByDr. Tamanna Anwar April 21, 2022November 25, 2023

The University of Alabama in Birmingham researchers have found 16 unique cell populations in a complex part of the midbrain known as the ventral tegmental area, or VTA, using single-cell RNA sequencing in a study that advances the field. Expanding our understanding of the VTA’s function will help us better understand the mechanisms behind substance…

Read More Single Cell RNA Sequencing Determines 16 Distinct Cell Populations in a Key Brain Area for Substance Use Disorders
Bioinformatics | COVID-19 | Covid-19 News | GWAS | NGS | RNA-Seq | Sequencing | Trending

First Cell Transcriptomic Atlas of a Non-Human Primate Completed by an International Team Led by BGI
ByDr. Tamanna Anwar April 15, 2022June 18, 2022

Researchers from BGI-Research, in collaboration with scientific research teams from China, Germany, Italy, Singapore, Spain, Sweden, and the United Kingdom, published the world’s first non-human primate whole-body cell transcriptomic atlas in the scientific journal Nature this week, in a breakthrough that could lead to scientific advancement in the treatment of human diseases. The study will…

Read More First Cell Transcriptomic Atlas of a Non-Human Primate Completed by an International Team Led by BGI
Bioinformatics | Gene Expression | News | NGS | RNA-Seq | Sequencing

Scientists Discovered ‘Junk DNA’ as the Key to Controlling Fear
ByDr. Tamanna Anwar March 29, 2022June 18, 2022

Scientists from the University of Queensland found, a bit of “junk DNA” could be the key to eradicating fear-related memories in persons suffering from post-traumatic stress disorder (PTSD) and phobia. While researching how the genome responds to traumatic experiences, an international research effort led by Associate Professor Dr. Timothy Bredy of the Queensland Brain Institute…

Read More Scientists Discovered ‘Junk DNA’ as the Key to Controlling Fear
Bioinformatics | Cancer Research | News | RNA-Seq | Sequencing | Tools | Trending

Scientists Developed a Computational Tool ‘CellTrek’ for Spatial Mapping of Single-Cell Data Within Tissues
ByDr. Tamanna Anwar March 28, 2022June 18, 2022

‘CellTrek’ can accurately map single cells in diverse tissue types to resolve their spatial organization. The tool identifies the location of particular cell types to drive biological insights. Scientists at The University of Texas MD Anderson Cancer Center have created a new computational methodology that successfully combines data from simultaneous gene-expression profiling approaches to build…

Read More Scientists Developed a Computational Tool ‘CellTrek’ for Spatial Mapping of Single-Cell Data Within Tissues
Bioinformatics | News | NGS | OMICS | Paper Summary | RNA-Seq | Sequencing | Trending

Scientists from the University of Helsinki Developed a Computational Platform ‘ScType’ for Fully Automated and Super Quick Identification of Cell-Type
ByTanveen Kaur March 17, 2022November 9, 2022

The researchers developed a computational platform ScType, which empowers a completely mechanized and super quick cell-type distinguishing proof-dependent exclusively upon given scRNA-seq information, alongside a thorough cell marker data set as foundation data. Utilizing six scRNA-seq datasets from different human and mouse tissues, it was shown how ScType gives fair-minded and precise cell type explanations…

Read More Scientists from the University of Helsinki Developed a Computational Platform ‘ScType’ for Fully Automated and Super Quick Identification of Cell-Type
Bioinformatics | Corona Virus | COVID-19 | Covid-19 News | OMICS | Precision Medicine | Proteomics | RNA-Seq | Sequencing

Scientists from the University of Oxford Published Covid-19 Multi-omic Blood Atlas (COMBAT) that Identifies Illness Severity and Specificity Markers
ByDr. Tamanna Anwar March 8, 2022October 22, 2026

In an integrated comparison with influenza and sepsis patients against healthy volunteers, the researchers show a complete multi-omic blood atlas for patients with different COVID-19 severity. Immune signatures and host response correlations are identified. Research describing markers of COVID-19 disease severity has been published by a multi-disciplinary, cross-divisional collaborative team led by the University of…

Read More Scientists from the University of Oxford Published Covid-19 Multi-omic Blood Atlas (COMBAT) that Identifies Illness Severity and Specificity Markers
Bioinformatics | Corona Virus | COVID-19 | Covid-19 News | Drug Discovery | RNA-Seq | Sequencing | Trending

Targeted Enzymes Knock Down Viral RNA
ByDr. Tamanna Anwar March 3, 2022October 22, 2026

The team of researchers led by the Technical University of Munich (TUM) was able to destroy the genetic code of SARS-CoV-2 by using particular enzymes, shortly after the virus had invaded the cell. The data might be utilized to design a novel COVID-19 treatment. The building instructions for proteins and other compounds are found in…

Read More Targeted Enzymes Knock Down Viral RNA
Bioinformatics | Cancer Research | Drug Discovery | Machine Learning | News | OMICS | Sequencing

Scientists Applied Machine Learning to Predict Therapeutic Response in Gastric Cancer
ByDr. Tamanna Anwar February 24, 2022October 22, 2026

The researchers at the Mayo Clinic Cancer Center in Florida, in a recent study published in Nature Communications, validate the use of genetic sequencing to predict whether patients with gastric cancer would benefit from chemotherapy or immunotherapy. Gastric cancer is one of the significant reasons for cancer-related deaths worldwide. Most patients with gastric cancer receive…

Read More Scientists Applied Machine Learning to Predict Therapeutic Response in Gastric Cancer
Bioinformatics | Biotech | News | RNA-Seq | Sequencing

Scientists Have Discovered a New Process Implicated in Learning and Memory
ByDr. Tamanna Anwar February 13, 2022June 18, 2022

Researchers from the Rockefeller University, United States revealed that FMRP, a protein that has been linked to fragile X syndrome, intellectual impairment, and some types of autism, has been found to play a critical role in various brain activities, assisting in the regulation of synaptic connections between neurons. When we memorize a password or learn…

Read More Scientists Have Discovered a New Process Implicated in Learning and Memory
Bioinformatics | Biotech | News | NGS | Sequencing

Mapping the Development of Cell Types and Tissues
ByDr. Tamanna Anwar February 12, 2022June 18, 2022

Researchers at Yale University, in collaboration with Karolinska Institutet in Stockholm, Sweden, have created a technology that allows them to look at epigenetic mechanisms driving tissue formation concurrently at a spatial and genome-wide level, a breakthrough with several scientific and medical applications. While existing technology allows scientists to study epigenetic information in the bulk of…

Read More Mapping the Development of Cell Types and Tissues
Bioinformatics | Biotech | Knowledge Graph | News | Sequencing | Trending

Top 7 Applications of Synthetic DNA in Information Technology
BySwati Yadav February 7, 2022November 8, 2022

Synthetic DNA is becoming a popular alternative to electronic-based technology in areas including data storage, product tagging, and signal processing, etc. To date, DNA has shown to be the ideal material for use in information technology. Watson–Crick base pairing is a fundamental feature of nucleic acids that provides the foundation for various DNA handling methods,…

Read More Top 7 Applications of Synthetic DNA in Information Technology
Bioinformatics | Cloud Computing | Corona Virus | Data Science | News | OMICS | RNA-Seq | Sequencing | Virus

Cloud Computing Helps Researchers Identify Over 100,000 RNA Viruses Including Nine New Coronavirus Species
ByDr. Tamanna Anwar January 30, 2022September 8, 2022

A team of scientists led by a former University of British Columbia (UBC) postdoctoral researcher in medical genetics discovered over ten times the number of RNA viruses previously thought to exist, including many novel coronavirus species. By re-analyzing all publicly accessible RNA sequencing data, the researchers were able to make the finding. They established a…

Read More Cloud Computing Helps Researchers Identify Over 100,000 RNA Viruses Including Nine New Coronavirus Species
Bioinformatics | Cancer Research | Genomics | Metagenomics | News | OMICS | Sequencing | Trending

A New Sequencing Technique Developed for Low-Biomass, Degraded, or Contaminated Microbiome Samples
ByDr. Tamanna Anwar January 28, 2022September 8, 2022

A low-cost metagenome sequencing technology has been developed by scientists from the Chinese Academy of Sciences’ Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT). It allows high-resolution disclosure of a microbiome’s whole ‘landscape’ of species, even from low-biomass, damaged, or polluted samples. The ‘microbiome‘ is referred to a community of microorganisms (bacteria, fungi, protists, and…

Read More A New Sequencing Technique Developed for Low-Biomass, Degraded, or Contaminated Microbiome Samples
Bioinformatics | Biomedical Engineering | Cancer Research | Genomics | News | RNA-Seq | Sequencing | Trending

Safely Inserting Therapeutic Genes into the Human DNA
ByDr. Tamanna Anwar January 27, 2022September 8, 2022

Researchers from Harvard’s Wyss Institute, Harvard Medical School, and the ETH Zurich have predicted and validated genetic safe harbors for therapeutic genes, making gene and cell treatments safer, more efficient, more predictable. According to the researchers, “genomic safe harbors (GSHs)” could enhance the efficacy, persistence, and predictability of future gene and cell therapies that are…

Read More Safely Inserting Therapeutic Genes into the Human DNA
Bioinformatics | Cancer Research | Data Science | News | Paper Summary | RNA-Seq | Sequencing | Tools | Trending

Expanding the View of how Mutations Impact Cells with a High-throughput Approach ‘Perturb-seq’
BySwati Yadav January 26, 2022September 8, 2022

Scientists from the Broad Institute of MIT and Harvard discovered an approach to studying the functional implications of the millions of mutations linked to cancer by pooling Perturb-seq and measuring the impact of TP53 and KRAS variants on RNA profiles in single cancer cells. Precision medicine entails predicting how specific genetic variants affect a patient’s…

Read More Expanding the View of how Mutations Impact Cells with a High-throughput Approach ‘Perturb-seq’
Bioinformatics | Biotech | News | Sequencing | Trending

‘Valves in DNA’ Created to Shape the Flow of Biological Information
ByDr. Tamanna Anwar January 25, 2022June 18, 2022

New biological components developed by scientists at the University of Bristol can alter the flow of cellular activities along DNA. The scientists provide new insights into how information is encoded in DNA and new tools for developing sustainable biotechnologies, in the research published in the journal Nature Communications. Transcriptional terminators tell RNA polymerases (RNAPs) when…

Read More ‘Valves in DNA’ Created to Shape the Flow of Biological Information
Bioinformatics | Biotech | Genomics | News | Sequencing

The Earth BioGenome Project Steadily Started Sequencing Genomes
ByDr. Tamanna Anwar January 19, 2022June 18, 2022

A worldwide endeavor to map the genomes of all life on Earth (plants, animals, fungi, and other microbes) is entering a new phase as it proceeds from pilot studies to full-scale production sequencing. The Earth BioGenome Project (EBP) has entered a new phase, as evidenced by a group of articles published this week in Proceedings…

Read More The Earth BioGenome Project Steadily Started Sequencing Genomes

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Sequencing

What is DNA Sequencing?

Scientists Discovered ‘Junk DNA’ as the Key to Controlling Fear

Scientists from the University of Oxford Published Covid-19 Multi-omic Blood Atlas (COMBAT) that Identifies Illness Severity and Specificity Markers

Scientists Applied Machine Learning to Predict Therapeutic Response in Gastric Cancer

Scientists Have Discovered a New Process Implicated in Learning and Memory

Mapping the Development of Cell Types and Tissues

Cloud Computing Helps Researchers Identify Over 100,000 RNA Viruses Including Nine New Coronavirus Species

The Earth BioGenome Project Steadily Started Sequencing Genomes

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