Transcriptomics

Researchers from the Children’s Hospital of Philadelphia, Philadelphia, USA, have created a versatile, easy-to-implement, and low-cost novel technique, TEQUILA-seq, for synthesizing large quantities of biotinylated capture oligos for any gene panel, that overcomes a substantial issue in Long-read RNA sequencing (RNA-seq). TEQUILA-seq’s ability to consistently and significantly enrich transcript coverage without interfering with transcript quantification…

Scientists from the University of California, Irvine, have developed NeuronChat for inferring inter-neuronal communication using single-cell transcriptomics data. Previous cell-cell communication inference methods are based on short-range signaling enabled by diffusion or physical contact. Neurons communicate via synapses involving neurotransmitter signaling and extend over long distances. The connectome, the wiring organization of neural connectivity, is…