De Novo Peptide Binder Generation: How moPPIt Targets ‘Undruggable’ Proteins
Authors from the University of Pennsylvania and others innovated the motif-specific PPI targeting algorithm (moPPIt), a computational framework that integrates BindEvaluator along with Multi-Objective Guided Discrete Flow Matching (MOG-DFM) to design peptides that can selectively bind functional motifs without needing structural priors. It works directly from sequence data instead of requiring known 3D structures, making…
