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Deep Learning Models in Pathogenicity Prediction: Insights from Hereditary Breast Cancer Gene Variants in the UK Biobank
Deep learning models have been used to predict the pathogenicity of mutations in hereditary breast cancer gene variants in the UK Biobank. Here, researchers classified germline missense mutations in UK Biobank individuals using three state-of-the-art deep learning models for pathogenicity prediction. The findings demonstrated that missense mutations in BRCA1, BRCA2, and PALB2 were linked to…