A light switch for the brain wins the Nobel The 2026 Nobel Prize in Physiology or Medicine goes to Karl Deisseroth, Peter Hegemann, and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.” The Nobel Assembly at Karolinska Institutet announced the award on 5 October 2026, and the three laureates share the 12…
Advancements in precision medicine have long promised a future where treatments are tailored to individual genetic profiles. However, despite significant progress in genomics, the full potential of personalized healthcare remains largely unrealized. In their paper “A Roadmap to Precision Medicine through Post-Genomic Electronic Medical Records,” researchers from Brigham and Women’s Hospital, Harvard Medical School, and…
Myeloid neoplasms are linked to mutations or deletions of the U1 snRNP-associated factor LUC7L2, and cellular metabolism is changed when LUC7L2 is knocked down. Here, researchers from MIT demonstrate that members of the LUC7 protein family widely influence mRNA splicing in leukemias with LUC7L2 copy number variation as well as human cell lines, and they…
A new study from deCODE genetics on actionable genotypes shows the potential of genetics to guide healthcare and improve outcomes. The research, published in the New England Journal of Medicine, screened the genomes of nearly 58,000 Icelanders for disease-linked variants. The results suggest that disease-causing gene variants (actionable genotypes) can significantly reduce lifespan by at least three years…
Scientists from the Earlham Institute and the University of Oxford have unexpectedly altered our understanding of the rules of genetics while testing a new single-cell sequencing method. A seemingly unique divergence in the genetic code signaling the end of a gene has been unveiled in the genome of a protist. This discovery suggests the imperative…
Understanding cellular responses to genetic changes holds vital importance in various biomedical contexts, such as uncovering cancer-related genetic interactions and advancing regenerative medicine. However, the vast number of potential multigene alterations poses a challenge for practical experimentation. In this regard, a novel method called the graph-enhanced gene activation and repression simulator (GEARS) has been introduced…
Scientists from the University of Helsinki, Broad Institute, and Harvard Medical School have revealed the human genetic epidemiology of the COVID-19 disease caused by SARS-CoV-2. The study indicates that the genetic association studies have been particularly fast in conveying new genetic signals underlying COVID-19 severity and disease susceptibility and can advance the treatment significantly. Human…
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