Gene Regulation

AI | Bioinformatics | Gene Expression | Machine Learning | News | Trending

Turning Genes On and Off: AI-Designed DNA Switches Revolutionize Gene Regulation
ByNeermita Bhattacharya November 3, 2024October 22, 2026

In this day and age, artificial intelligence is everywhere; it’s omnipresent. It is utilized in healthcare, finance, entertainment, IoT, agriculture, marketing, cybersecurity, and so much more! In this article, we dive into the innovative ways researchers have found to integrate AI with genomics. The possibility of tuning the expression of certain genes in organisms has…

Read More Turning Genes On and Off: AI-Designed DNA Switches Revolutionize Gene Regulation
AI | Big Data | Bioinformatics | Computational Models | Gene Expression | Genomics | Machine Learning | News | OMICS | Paper Summary | RNA-Seq | Tools | Trending

Decoding the Regulatory Landscape with LINGER: A New Era in Gene Regulatory Networks Inference
ByDeotima Chakraborty April 27, 2024October 22, 2026

Despite the difficulties presented by the current methods depending solely on gene expression data, RNA sequencing data has been incorporated into Gene regulatory networks (GRN) inference methods, improving the capacity to learn complicated pathways from a few independent data points. Here, scientists offer LINGER (Lifelong neural network for gene regulation), a machine-learning technique that uses…

Read More Decoding the Regulatory Landscape with LINGER: A New Era in Gene Regulatory Networks Inference
Bioinformatics | Cancer | News | NGS | Paper Summary | RNA-Seq | Tools | Transcriptomics | Trending

Unlocking Cellular Secrets: SCORPION’s Breakthrough in Population-level Comparisons of Gene Regulatory Networks
ByAnchal Negi March 10, 2024October 22, 2026

Gaining insight into the intricate workings of genes within cells is essential to comprehending biological processes and illnesses. Bulk RNA sequencing, which hides diversity within cell populations and analyzes average gene expression across numerous cells, has historically been the focus of study. On the other hand, single-cell RNA sequencing, or scrRNA-seq, has become a powerful…

Read More Unlocking Cellular Secrets: SCORPION’s Breakthrough in Population-level Comparisons of Gene Regulatory Networks
AI | Bioinformatics | Deep Learning | Gene Expression | Genomics | News | Paper Summary | Trending

Unlocking the Enhancer Code: Deep Learning’s Role in Designing Cell-specific Genetic Switches
ByAnchal Negi February 4, 2024October 22, 2026

Transcriptional enhancers control the spatiotemporal activation of the target genes they regulate by serving as docking stations for various transcription factor combinations. It has been a long goal to Decipher the regulatory logic of an enhancer and comprehend the specifics of how spatiotemporal gene expression is encoded in an enhancer sequence. Researchers from VIB Center…

Read More Unlocking the Enhancer Code: Deep Learning’s Role in Designing Cell-specific Genetic Switches
Bioinformatics | Gene Expression | News | Paper Summary | Sequencing | Trending

ChIP-DIP Multiplexing Method Maps Hundreds of Proteins to DNA Decoding Gene Expression Regulation
ByDeotima Chakraborty December 30, 2023January 4, 2024

The dynamic localization of thousands of unique regulatory proteins to specific DNA sequences regulates the expression of genes. It has been a longstanding objective of molecular biology to comprehend this cell-type specific mechanism. However, it is still difficult because the majority of DNA-protein mapping techniques only look at one protein at a time. A study…

Read More ChIP-DIP Multiplexing Method Maps Hundreds of Proteins to DNA Decoding Gene Expression Regulation
AI | Bioinformatics | Cell | Computational Models | Deep Learning | Drug Discovery | News | NGS | Paper Summary | RNA-Seq | Trending

GeneCompass: A New Foundation Model that Unlocks the Secrets of Gene Regulation Across Species
BySwasti Tyagi October 4, 2023December 7, 2023

A team of researchers from the University of Chinese Academy of Sciences, China, and collaborators developed GeneCompass, one of the first foundation models of its kind that encompasses a vast expanse of knowledge across a diverse array of species, owing to the fact that it has been trained on over 120 million single-cell transcriptomes derived…

Read More GeneCompass: A New Foundation Model that Unlocks the Secrets of Gene Regulation Across Species
Bioinformatics | Genomics | News | Paper Summary | Tools | Trending

Scientists Develop a New Computational Tool ‘Grit’ to Identify Upstream Transcription Factor Binding Sites More Accurately
ByTanveen Kaur June 16, 2022June 16, 2022

Scientists from Yangtze University, Jingzhou, China developed a computational tool, “Grit,” to identify the upstream transcription factor binding sites in orthologous genes by the utilization of mixed Student’s t-test statistics. The transcription factor (TF) regulates the transcription of DNA to messenger RNA or mRNA by binding to upstream sequence motifs. Distinguishing the locations of known…

Read More Scientists Develop a New Computational Tool ‘Grit’ to Identify Upstream Transcription Factor Binding Sites More Accurately
Bioinformatics | Cancer Research | Computational Models | Gene Expression | Machine Learning | News | OMICS | Paper Summary | Trending

Scientists Develop a Machine Learning-Based Framework to Identify Shared and Disease-Specific Host Gene-Microbiome Associations Across Human Diseases
ByTanveen Kaur May 20, 2022December 28, 2022

Scientists from the University of Minnesota, Minneapolis, USA, with their collaborators, developed a machine learning framework for a multi-omic integration to identify the shared and disease-specific host gene microbiome associations across human diseases. They identified the associations between gut microorganisms and host genes that portray shared as well as disease explicit patterns. While gut microbiome…

Read More Scientists Develop a Machine Learning-Based Framework to Identify Shared and Disease-Specific Host Gene-Microbiome Associations Across Human Diseases

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