EPBDxDNABERT-2: A Multi-Modal Deep Learning Model for Enhanced Transcription Factor DNA Binding Prediction
It has been demonstrated that there is a functional correlation between transcriptional activity, thermodynamic stability, DNA breathing, and transcription factor (TF) binds. The researchers created the multi-modal deep learning model EPBDxDNABERT-2, which is based on the Extended Peyrard-Bishop-Dauxois (EPBD) nonlinear DNA dynamics model, to determine the exact link between TF binding and DNA breathing. With…
