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AI-Driven Macrocycle Design: How RFpeptides Generate High-Affinity Protein Binders for Diagnostics and Therapeutics
Large-scale screening techniques that are resource-intensive and offer limited control on binding mode are usually used to produce macrocyclic binders to therapeutic proteins. There are currently no reliable methods for the de novo design of protein-binding macrocycles, despite significant advancements in deep-learning methods for protein design and physics-based methods for peptide design. In this work,…
