Researchers from Yale University and other institutions have identified MED6-189 as a new antimalarial drug, a new development that might change the dynamics of malaria treatment. This new compound is active against sensitive and resistant forms of Plasmodium falciparum, which is the most virulent. Malaria, a devastating disease caused by parasitic protozoans of the genus…
Antibiotic resistance is increasing as a global problem, meaning previously effective treatments for bacterial infections have ceased to work. It is vital to accurately identify the antibiotic resistance profile of an infection to choose the right antibiotic and improve patient outcomes. In Germany, researchers from the Technical University of Munich (TUM) are exploring this possibility…
Antibiotic resistance is one of the most pressing challenges in modern medicine. As bacteria evolve to withstand our best treatments, once-manageable infections are becoming increasingly difficult, if not impossible, to treat. Among the most notorious of these resistant bacteria are those that resist quinolone antibiotics, a critical class used to treat a variety of infections….
Scientists from Waseda University and Hitachi, Ltd., Japan, developed a novel approach for predicting antibiotic resistance genes (ARGs) resistance mechanisms using Protein-BERT, a protein language model based on deep learning. This model excels at predicting resistance for genes with low similarity to known sequences. By analyzing biologically relevant features like conserved residues and binding sites,…
AI is being used to find novel antibiotics for bacteria resistant to pandemics; however, the currently used techniques have serious drawbacks. While generative models design molecules—which are difficult to synthesize—property prediction models, which assess molecules individually, have difficulty scaling to enormous chemical spaces. The generative model SyntheMol, which creates readily synthesizable chemicals from a chemical…
Since the discovery of penicillin, a large number of antibiotics have been developed and used all over the world as a means to cure disease. While this has been a boon for humanity, allowing for the easy, effective, and cheap treatment of microbial disease, its misuse has also resulted in many pathogens developing resistance to…
The University of Utrecht scientists have uncovered a novel mechanism for how drugs eradicate antibiotic-resistant bacteria. Teixobactin, an antibiotic, kills bacteria by destroying their cell membrane and preventing the formation of their cell walls, according to research published in the peer-reviewed journal Nature. The new understandings might make it possible to create potent antibiotics that…
Scientists from the University of New South Wales have discovered a complex system for adaptability in Staphylococcus aureus that has led to the identification and characterization of multi-drug resistance mechanisms as well as the development of new lines of antibiotic defense. The remedy for methicillin-resistant S. aureus infections depends on the effectiveness of the last-line antibiotics such as vancomycin….
New research from University of Oxford revealed that superbug Pseudomonas develops resistance to a common ‘last-resort’ antibiotic much faster than expected. Recent research published in Cell Reports this week shows how populations of the bacterium Pseudomonas react to treatment with Colistin, a ‘last resort’ antibiotic for patients with multidrug-resistant infections. Antibiotics are essential for human health because they help…
Scientists from Inserm, Université Sorbonne Paris Nord, and Université Paris-Cité at the IAME Laboratory, with their collaborators at Institut Pasteur and the Paris Public Hospitals Group (AP-HP), develop an in silico model in combination with in vivo phage therapy data to highlight vital parameters for increasing the efficiency of pneumonia treatment. The clinical (re)development of…
Antibiotic-degrading microbes could help avoid opportunistic infections and reduce antibiotic resistance. Antibiotic-induced changes in the gut microbiota have been linked to a variety of metabolic and inflammatory illnesses, as well as an increased risk of subsequent infections and the development of antibiotic resistance. Scientists from Massachusetts Institute of Technology designed and evaluated the in vivo…
The World Health Organization (WHO) appraises that 700,000 individuals now die yearly because of antibiotic resistance and anticipates that this number will surpass 10 million every year by 2051. Stanford University scientists developed machine learning models that predict antibiotic susceptibility patterns (personalized antibiograms) using electronic health record data. Personalized empiric antibiotic subscription with personalized antibiograms…
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