RNA Structure Prediction

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RhoFold+: Transforming RNA 3D Structure Prediction with Deep Learning
ByDeotima Chakraborty November 28, 2024October 22, 2026

Although RNA 3D structures are important in understanding their functions and in the design of new drugs, their accurate prediction is still a challenge. Structural flexibility makes computational predictive efforts even more problematic because of the scarcity of experimental input. In this study, researchers from The Chinese University of Hong Kong, Harvard University, Fudan University,…

Read More RhoFold+: Transforming RNA 3D Structure Prediction with Deep Learning
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RNA-FrameFlow: Pioneering 3D RNA Backbone Design with Flow Matching
ByAnshika Gupta July 15, 2024October 22, 2026

A part of systems biology is ‘designing RNA structures,’ which entails planning and organizing molecules of RNA into custom 3D formations with particular uses. RNA plays a dual role in cells, encoding genetic information and performing structural functions. Proteins are somewhat easier to study and model because of the precision nature of this macromolecule, while…

Read More RNA-FrameFlow: Pioneering 3D RNA Backbone Design with Flow Matching
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Breaking New Ground in RNA Structure and Sequence Design with RNAFlow
ByAnchal Negi June 3, 2024October 22, 2026

Unsung heroes of our cells are RNAs. These molecules are responsible for many biological processes, from carrying hereditary material to controlling protein production. However, imagine being able to change the functions of RNAs for medical purposes or scientific studies. In their latest research, scientists from the Massachusetts Institute of Technology and Broad Institute of MIT…

Read More Breaking New Ground in RNA Structure and Sequence Design with RNAFlow
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UC Berkeley’s Breakthrough RNA Language Models Predict Mutations that Enhance RNA Function
ByAnchal Negi April 15, 2024October 22, 2026

A new tool from UC Berkeley can predict mutations that can improve the way how RNA works. By leveraging hyperthermophilic RNAs, the researchers identified mutations conferring increased thermostability to E. coli ribosomes, providing a foundation to understand RNA sequence-structure-function relationships. Introduction Do you remember what DNA is? It’s that molecule that contains all the information…

Read More UC Berkeley’s Breakthrough RNA Language Models Predict Mutations that Enhance RNA Function
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Unveiling the Power of Deep Learning: A Comprehensive Benchmark of Tertiary RNA Structure Prediction Methods
ByDeotima Chakraborty February 12, 2024October 22, 2026

Before understanding RNA biology, one must grasp the three-dimensional structure of RNA. Because experimental procedures require a lot of labor and money, computer approaches have emerged. With the use of machine learning and physics-based concepts, these techniques can quickly anticipate RNA structures. On the other hand, their accuracy is still not as high as that…

Read More Unveiling the Power of Deep Learning: A Comprehensive Benchmark of Tertiary RNA Structure Prediction Methods
AI | Bioinformatics | Database | Deep Learning | News | Structural Biology | Trending

Revolutionize RNA Structure Prediction with RNA3DB: The Pinnacle Dataset for Training Deep Learning Models
ByDr. Tamanna Anwar February 6, 2024October 22, 2026

Harvard University researchers introduce RNA3DB, a dataset crafted from the Protein Data Bank (PDB), addressing challenges in RNA structure prediction. In response to limitations in existing literature and recent findings in CASP15, RNA3DB offers a non-redundant dataset for training and benchmarking deep learning models. With the success of deep learning in protein structure prediction, there…

Read More Revolutionize RNA Structure Prediction with RNA3DB: The Pinnacle Dataset for Training Deep Learning Models
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Achieving RNA’s AlphaFold Moment: How Close Are We?
BySwasti Tyagi September 26, 2023February 6, 2024

AlphaFold’s breakthrough in solving the protein structure prediction problem has ignited enthusiasm to apply similar methods to predict the 3D structures of RNAs. However, achieving this feat presents significant challenges. A review paper titled ‘When will RNA get its AlphaFold moment?’ recently published in Nucleic Acids Research, discusses, in-depth, the various challenges faced by scientists over the…

Read More Achieving RNA’s AlphaFold Moment: How Close Are We?
AI | Bioinformatics | Computational Models | Drug Discovery | Machine Learning | News | Paper Summary | Structural Biology | Trending

Meet DRfold: A Novel Method to Predict RNA Tertiary Structures with Unprecedented Accuracy
ByPrachi Khare September 21, 2023October 22, 2026

RNAs are essential components of physiological activities, however, accurately modeling their structures has long posed a challenge due to their complex structures. The National University of Singapore researchers introduced DRfold, an innovative technique to predict RNA complex 3D structures. By simultaneously learning local frame rotations and geometric constraints from experimentally solved RNA structures, DRfold addresses…

Read More Meet DRfold: A Novel Method to Predict RNA Tertiary Structures with Unprecedented Accuracy

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