RFdiffusion

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Advancing Enzyme Design: RFdiffusion2 Enables Atomic-Level Scaffold Generation
ByDeotima Chakraborty May 15, 2025October 22, 2026

In de novo enzyme design, the functional groups surrounding reaction transition states are described in the optimal active site. There are drawbacks to the generative AI technique RFdiffusion, which has been used to build highly active enzymes. The active site’s geometry can only be defined at the residue level, necessitating the construction of side chain…

Read More Advancing Enzyme Design: RFdiffusion2 Enables Atomic-Level Scaffold Generation
AI | Bioinformatics | Covid-19 News | Drug Discovery | Machine Learning | News | Paper Summary | Structural Biology | Trending

Creating Antibodies from Scratch: Scientists Design Single-Domain Antibodies with Atomic Precision Using AI
ByDeotima Chakraborty March 21, 2024October 22, 2026

The inability to logically design new antibodies that bind a particular epitope on a target persists despite the crucial role that antibodies play in contemporary medicine. Instead, time-consuming animal immunization procedures or library screening techniques are currently used in antibody development. Here, scientists from the University of Washington show that user-specified epitopes can be bound…

Read More Creating Antibodies from Scratch: Scientists Design Single-Domain Antibodies with Atomic Precision Using AI
AI | Bioinformatics | Machine Learning | News | Paper Summary | Proteomics | Structural Biology | Tools | Trending

Unveiling the Future of Protein Design: RFdiffusion’s De Novo Revolution
ByDeotima Chakraborty January 26, 2024October 22, 2026

Protein design has seen significant progress, but a comprehensive deep-learning framework for protein design, including de novo binder design and higher-order symmetric architectures, remains unexplored. Diffusion models have shown success in image and language generative modeling but have limited success in protein modeling due to the complexity of protein backbone geometry and sequence-structure relationships. The…

Read More Unveiling the Future of Protein Design: RFdiffusion’s De Novo Revolution

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