Teixobactin Kills Bacteria by Attacking the Cell Envelope in Two Ways
The development of new mechanisms for antibiotics is essential to combating antimicrobial resistance. With its unique chemical scaffold, Teixobactin is a new class of antibiotics that lacks detectable resistance. A precursor of peptidoglycan, lipid II, is targeted by Teixobactin. Teixobactin binds specifically to the sugar moiety of lipid II at its C-terminal enduracididine headgroup, whereas…
