Variant Scientist – Remote

Job: Variant Scientist – Remote

Category: Research and Development 

Job Id: 2315369 Job Type

Type: Full-Time

The Women’s Health and Genetics division of LabCorp is seeking a Variant Scientist to join our Variant Science Group (VSG) team. Variant Science is a very important component of our overall strategy and growth in genomics. You’ll be part of a dynamic team with diverse backgrounds in genetics, nutrition, PGD, computational biology, metabolism and physiology. The Variant Scientist is responsible for classification of inherited and somatic sequence variants identified through Targeted NGS DNA sequencing and WES case triage review in a high throughput clinical laboratory setting.  The VSG contributes to data sharing, supports gene and panel content development for a wide array of disorders and develops our in-house semi-automated rules based classification workbench while exploring automated approaches to scale up our ever growing variant classification needs. These efforts have resulted in peer-reviewed publications, and presentations at prominent scientific meetings. A strong background in Human Genetics as well as familiarity with human mutation databases and HGVS nomenclature is essential.

Please note: this position has the option to be 100% remote, or physically located at our laboratory in Westborough, MA or RTP, NC. The schedule for this position will be Monday – Friday, 8am-5pm local time zone.

Responsibilities:

• Classify and interpret human genetic/genomic variants in accordance with company SOPs
• Maintain communication with laboratories located within or outside LabCorp
• Maintain tracking documents in relation to the variant-classification process
• Maintain active reports on variant processing status and performance
• Trouble shoot NGS pipeline variant annotations as required
• Communicate frequently with the Laboratory Directors, Medical Geneticists and Genetic Counselors regarding variant assessment
• Interact with the software vendors/IT/bioinformatics group(s) regarding technology needs as and when required
• Opportunity to take part in company projects, publications and posters at scientific meetings of relevance to the organization

Requirements: 

• PhD in Life Sciences (Genetics / Molecular Biology /Biochemistry /Experimental Pathology) or Master’s in Genetic Counseling with a strong background in Human Genetics and WES/NGS technologies
• Minimum 1 year of experience in classifying variants based on ACMG guidelines in a clinical setting required
• 3 years of  relevant variant interpretation experience highly preferred
• Strong analytical capabilities, scientific writing and communication skills, organization, and the ability to critically review, comprehend, ascertain and document relevant clinical and functional data from scientific publications and online databases
• Ability to use bioinformatics software and Microsoft Office suite of products (specifically use of Microsoft Excel to mine, parse and automate analysis of datasets)
• Proficiency with large NGS datasets, in-silico tools, HGVS nomenclature, and genome browsers.
• Ability to meet production timelines with a sense of urgency and ethical responsibility in a rapidly evolving dynamic setting
• Experience classifying variants based on ACMG guidelines is desirable, but not required.

Benefits: All job offers will be based on a candidate’s skills and prior relevant experience, applicable degrees/certifications, as well as internal equity and market data. Regular, full-time or part-time employees working 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(K), ESPP, Paid time off (PTO) or Flexible time off (FTO), Commissions, and Company bonus where applicable.  For more detailed information, please click here.

Labcorp is proud to be an Equal Opportunity Employer:

As an EOE/AA employer, Labcorp strives for diversity and inclusion in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications of the individual and do not discriminate based upon race, religion, color, national origin, gender (including pregnancy or other medical conditions/needs), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. We encourage all to apply.

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