Senior/Principal Bioinformatician (Structural Biology)

Job Title: Senior/Principal Bioinformatician (Structural Biology)

Job Overview

Amphista Therapeutics is a fast-growing Cambridge-based biotech and the leading European Targeted Protein Degradation (TPD) company. Our unique scientific approach to TPD, one of the hottest areas in modern drug discovery, gives us a range of advantages over other therapeutic strategies.

We have completed an oversubscribed $53M funding round which was recently extended with investment by the Dementia Discovery fund. During 2022 we were delighted to announce in two separate collaboration deals with Bristol Myers Squibb and Merck Healthcare which will allow us to grow and advance our therapeutic portfolio even faster. This excellent progress has been recognised Amphista named as a Fierce Biotech, Fierce15 winner for 2022.

At Amphista we take the quality and how we access, analyse and share data seriously As a result we are expanding our bioinformatics and data science team and are looking for innovative and highly motivated Senior/Principal Bioinformatician to join us. You will be responsible for driving development of databases that let us understand the best targets and approaches to deliver novel therapies to patients. We will be mining the public datasets, interrogating the data as well as integrating the increasingly large datasets we are generating in house on Amphista’s completely novel degrader molecules. The applicant will work closely with the R&D team members across all Amphista’s projects to process, store and visualise external and internal omics data types to help addressing key drug discovery questions. Contributing to Amphista’ drug development program as a technical expert and developing the strategy top ensure all scientists can access and make use of the data.

Responsibilities

• Collaborate and communicate effectively across multidisciplinary teams of experts in biology, chemistry, and bioinformatics
• Drive and develop data analysis tools facilitating our drug discovery programs
• Provide computational structural biology input to our programs
• Contribute to updating our Bioinformatics databases

Experience

Essential:

• Proficient with bioinformatics tools for computational modelling of protein structure mining (Rosetta, etc.)
• Familiarity with protein visualization software
• Experience with protein sequence analysis (HMMER,etc)
• Expertise in mining publicly available datasets relevant to drug discovery
• Skilled in data integration
• Strong programming skills in Python and/or R
• Experience with version control and cloud computing
• Ability to communicate clearly technical concepts to multi-disciplinary teams

Desirable:

• Experience in building visualisation tools and front-end technologies
• Experience in drug discovery preferably within a fast-paced biopharma or biotech environment leading informatics projects

Education and Qualification

• MSc or above in bioinformatics, biophysics, computer science, life science or a similar area
• Highly motivated proactive individual keen to take ownership
• Ability to work to deadlines whilst maintaining quality
• Can-do attitude

What’s on offer

Competitive salary and benefits package including share options and discretionary bonus

Hybrid working

About Amphista:

Amphista Therapeutics is a fast-growing Cambridge-based biotech and the leading European Targeted Protein Degradation (TPD) company. Our unique scientific approach to TPD, one of the hottest areas in modern drug discovery, gives us a range of advantages over other therapeutic strategies. In addition to an oversubscribed $53M funding round in 2021. We were delighted to recently announce two separate collaboration deals with Bristol Myers Squibb and Merck Healthcare which will allow us to grow and advance our therapeutic portfolio even faster. Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies.

Please note that we are unable to offer visa sponsorship.