Scientific Associate-I

    Scientific Associate-I

    Website University Health Network

    Posting Date: 14-04-22
    Closing Date:
    Until Filled

    Profile: Scientific Associate-I
    Company: University Health Network
    Salary Range: $65,091 – $81,354 per annum (Commensurate with experience and consistent with UHN Compensation Policy)
    Type: Permanent, Full-time
    Site: Princess Margaret Cancer Centre

    Overview: University Health Network (UHN) is looking for an experienced professional to fill the key role of Scientific Associate I in our Research Department.

    Transforming lives and communities through excellence in care, discovery and learning.

    The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

    University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN’s five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here. The Terry Fox Research Institute Marathon of Hope Cancer Network (MOHCCN) Project aims to create a “gold-standard” cohort of clinical cancer specimens with well-annotated, uniformly generated and consistently quality-controlled data set (clinical and genomic) from 15k to 30k cases collected from across Canada over 5 years. In addition to the objectives to build a pan-Canadian Cancer Network and to produce immediate clinical impact by identifying actionable targets through molecular profiling, the TFRI MOHCCN program aims to generate in-depth molecular profiling data from cancer patient cohorts to address important scientific questions.
    The Princess Margaret Cancer Consortium (PM2C) is a collaboration between Princess Margaret Cancer Centre – University Health Network (PM-UHN), and the Ontario Institute for Cancer Research (OICR). This partnership aims to build upon existing infrastructure and expertise in clinical research, pathology, biobanking resources, next generation sequencing, tumor molecular profiling, data informatics, and patient/community engagement to establish best-practices models for precision cancer medicine and translational research in Ontario. For more information about TFRI MOHCCN and PM2C (https://www.marathonofhopecancercentres.ca/our-network/consortium/princess-margaret-cancer-consortium)
    As the MOHCCN-PM2C Scientific Associate specializing in data science, you will be responsible for coordinating and maintaining process flow of MOHCCN-PM2C datasets, including whole genome, transcriptome and digital pathology image data. You will liaise between MOHCCN-PM2C-selected research groups (PMH and external sites), UHN biobank and correlatives studies services, Ontario Institute for Cancer Research (OICR) Genomics, and MOHCCN network approved data sharing agencies (CanDIG/DHDP), to support the data generation and sharing objectives of MOHCCN.

    This role requires a unique combination of domain knowledge spanning cancer genomics, bioinformatics, clinical research, and project management. You will have the option to work remotely, on-site, or hybrid.

    QUALIFICATIONS:

    • PhD. in cancer genetics, molecular biology, bioinformatics, or related field
    • At minimum, once (1) year of related experience
    • Familiarity with working on a high-performance computing cluster environment (SLURM, bash scripting)
    • Programming (bash, R, python)
    • Experience with genomic sequencing data analysis, data visualization, and interpretation (WGS, RNA-seq)
    • Knowledge in clinical correlatives research, cancer genomics, genomic sequencing and clinical specimens workflows for NGS.
    • Excellent organizational and time management skills required.
    • Excellent interpersonal, verbal, and written communication skills.
    • Ability to set priorities and work independently with accuracy in a fast-paced multitasking environment
    • Strong Proficiency with MS Office software, Word, Excel, Outlook, and PowerPoint


    RESPONSIBILITIES:

    • Track and report weekly progress on whole genome and transcriptome sequencing (WGTS) data transfer, generation, processing, and interpretation.
    • Prepare, organize, and present cohort progress in recurring meetings to internal and external stakeholders (PM2C cohorts, Steering Committee, PM2C core team, OCI Faculty, Network-level meetings)
    • Data storage maintenance and organization for MOHCCN-PM2C.
    • Provide expertise to make recommendations to improve and troubleshoot WGTS data process and sharing.
    • Contribute to bi-monthly research progress reports for TFRI.
    • Contribute to design of new research projects (ie. grant applications) and perform appropriate data analysis from clinical and MOHCCN-PM2C WGTS datasets
    • Perform data analysis and results interpretation to preparing abstracts, presentations, and manuscripts to support MOHCCN-PM2C research projects.
    • Perform data analysis and results interpretation to preparing abstracts, presentations and manuscripts for Cancer Genomics Program/Tumor Immunotherapy Program sponsored research activities.
    • Assist clinical groups in the design of new correlative studies and write up of accompanying lab manuals and protocols.

    Vaccines (COVID-19 and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

    If you are interested in making your contribution at UHN, please apply on-line. You will be asked to copy and paste as well as attach your resume and covering letter. You will also be required to complete some initial screening questions.

    For current UHN employees, only those who have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN’s attendance management program, and possess all the required experience and qualifications should apply.

    UHN thanks all applicants, however, only those selected for an interview will be contacted.

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