Research Scientist I

    Research Scientist I - - Bioinformatics Jobs

    Website Medical College of Wisconsin (MCW)

    Requisition ID #: 30451

    Job Category: Research

    Employment Type: Full Time

    Experience Level: Entry Level

    City, State: Milwaukee, WI

    Work Location: MACC Fund Research Center

    Department: Medicine

    Education: Doctorate Degree

    Date Posted: 25.04.2022

    Position Description:

    Position Summary 

    POSITION TITLE: Research Scientist I

    Purpose: A Research Scientist I position is immediately available in the laboratory of Dr. Anthony E. Zamora in the Division of Hematology and Oncology, Department of Medicine at the Medical College of Wisconsin. The Zamora lab’s research focuses on identifying ways to modulate the immune system to more effectively target and eliminate cancerous cells. Along these lines, the lab utilizes cellular-based engineering approaches that aim to increase the specificity of immune cells for their targets and at the same time decrease the likelihood of off-target toxicities.

    Current research in the Zamora lab focuses on: (1) discovering tumor antigens that serve as immunogenic targets, (2) identifying the mechanisms involved in the immune system’s ability to generate antitumor specificities, (3) characterizing the phenotypic, functional, and receptor repertoires of NK cells and neoantigen-specific T cells, and (4) exploring ways to translate these findings to expand on the current therapeutic options used to treat cancer.

    Highly motivated individuals with a PhD and experience in various immunological, biochemical, molecular, and cellular techniques are encouraged to apply. Experience with flow cytometry, PCR, RNA-seq, cell culture, and other immunological techniques is required. Previous Experience with sequencing, single-cell analysis, computational/bioinformatic analysis is desired. Participation in lab meetings and journal club is required. Individuals will also be expected to participate in the writing and publication of manuscripts.

    This position is NOT RESTRICTED to permanent U.S. residents or citizens.

    Primary Functions

    • Perform immunology and cancer immunotherapy experiments from design conception to data analysis and presentation of results.
    • Design and execute complex research procedures.
    • Develop and perform routine and complex protocols for research programs.
    • Prepare scientific papers and present scientific data at local and national meetings.
    • Assist the principal investigator with preparing and reviewing grant applications.
    • Coordinate research study activities; lead and manage projects.
    • Assist in developing, implementing and monitoring quality activities.
    • Collaborate with principle investigators in determining study design and performing statistical analyses.
    • Perform and develop routine and complex computational and database methods for implementation.
    • Develop new methodologies for lab procedures.
    • Maintain supplies, may negotiate with vendors, track purchase orders.
    • Participate in meetings with principle investigator and research staff and evaluate/interpret the validity of data, develop methodologies, evaluate lab procedures.
    • May oversee the work of laboratory personnel including training and development as well as daily work direction/delegation/prioritizing. Participate in training of other lab personnel to achieve experimental and educational goals.

    Preferred Schedule:
    Full-time role with expectations for coverage during core business hours and flexibility required as necessary to accommodate business needs.

    Position Requirements:

    Knowledge – Skills – Abilities

    • Understanding of general and advanced laboratory procedures, scientific approaches, and methodologies is essential.
    • Experience with immunological, biochemical, molecular, and cellular techniques is required.
    • Experience with sequencing and single-cell analysis is preferred; computational/bioinformatic experience is desired, but not required.
    • Experience with handling of laboratory animals is preferred, but not required.
    • Experience working with grant coordinators to track and monitor spending is highly desired.
    • Ability to develop and follow research protocols is required.
    • Ability to effectively communicate and share ideas with collaborators and researchers in other labs is highly desired.
    • Knowledge of biology, chemistry, mathematics, documentation, and record management.
    • Data utilization, complex problem solving, critical thinking, resource management, and writing skills.
    • Ability to read, understand, follow, and enforce safety procedures.

    Organizational Structure

    Building:                                   MACC Fund Research Building, Suite 6072

    Department:                              Medicine

    Division:                                   Hematology and Oncology

    Reports to (Title):                      Principal Investigator – Dr. Anthony E. Zamora

    Collaborates with (Titles):           Rotating Students, Graduate Student Researchers, Research Staff

    Specifications

    Minimum Required Education:   PhD in a scientific field

    Minimum Required Experience:  No experience required

    Preferred Education:                  PhD in Immunology, Molecular Biology, Cancer Biology

    Preferred Experience:                Experience in Immunology, molecular and cellular biology, cancer biology, and/or cancer immunotherapy research.

    Classification

    Grade Name                             R15

    Full-Time Equivalent                  1.0

    FLSA Status                             Exempt

    FLSA Test                                 Learned Professional

    Workweek                                 Full-time role with expectations for coverage during core business hours and flexibility required as necessary to accommodate business needs.

    Job ID                                      283

    Job Name                                 Research Scientist

    Position Category                      Research Services (RS)

    Job Scope

    Complexity – regularly applied judgment to accomplish tasks; develops policies and procedures

    Impact – errors may cause moderate to serious damage; accuracy highly important

    Autonomy – performs work independently with regular check-ins; supervision available as needed

    Communication – occasionally resolves conflicts; adapts communication style to audiences

    Responsibility – advises others

    Confidentiality – regularly prepares and uses confidential information

    Leadership – acts as a role model

    Physical Requirements

    Work requires occasionally lifting moderate weight materials, standing, or walking continuously.

    Risk Potential

    Little or no exposure to hazards such as dust, fumes, or extreme temperatures, airborne or blood borne pathogens, extreme temperatures, or allergens. There is some risk of exposure to blood borne pathogens that is mitigated by strict adherence to biosafety protocols.

    Sensory Acuity

    Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.

    Work Environment

    Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.

    Performance Dimensions

    Collegiality

    Exhibit confidentiality, honesty, and actions that build trust and strengthen relationships. Listen to others and effectively communicate in a clear and concise manner through written and verbal communication. Demonstrate respect and commitment to the values of diversity and equity; seek out and incorporate diverse perspectives into decision making.

    Excellence and Creativity

    Exhibit initiative and ingenuity by taking ownership of tasks to proactively improve services, avoid problems, or develop opportunities. Generate novel and valuable ideas to impact institutional missions.

    Identify and implement new methods to increase efficiency and quality.

    Education and Development

    Displays an ongoing commitment to continuous learning and self-improvement in one’s area of responsibility. Actively seek out mentorship and learning opportunities that can be applied to current and future work activities. Develop and maintain professional affiliations. Participate in design, development, and/or evaluation of instructional materials, methods, courses, or programs.

    Agility and Judgment

    Remain flexible and versatile in rapidly changing environment and adapt quickly to changing circumstances. Change behavioral style or method of approach when necessary to achieve a goal. Make timely and sound decisions based on analysis of information, experience, and logic. Show reliability and accountability in the successful completion of all work.

    Stewardship and Institutional Citizenship

    Support transformational change to achieve institutional vision and strategies. Be an active and thoughtful participant in institutional initiatives, meetings, and committee work. Conserve resources and use in an efficient and cost effective manner across all institutional missions. Look for ways to improve and promote quality within area of influence.

    Disclaimers

    Background Check

    Employment in this position may be contingent upon successfully completing a background and criminal history check, caregiver background check in accordance with the Wisconsin Caregiver Background Check

    Law, physical examination, and / or driving record check.

    Equal Opportunity Employer

    The Medical College of Wisconsin is an affirmative action / equal opportunity employer and does not discriminate in hiring or employment on the basis of age, sex, race, color, religion, national origin, veteran status, disability, or sexual orientation.

    Diversity and Inclusion

    The Medical College of Wisconsin defines diversity as a commitment to recognizing and appreciating the variety of individual differences in an environment that promotes and celebrates individual and collective achievement. The diversity of MCW continues to be an important source of innovative ideas and creative accomplishments.

    Confidentiality

    Employees that have access to MCW, affiliate, subsidiary, or student data or Protected Health Information

    (PI), or research protected information are obligated to protect the confidentiality and proper use and access of this information in order to prevent loss, misuse, unauthorized access, unnecessary identification, or security breaches.

    Completeness

    This job description is not an employment contract and the Medical College of Wisconsin may modify this document at any time. This document is intended to indicate the types of tasks and levels of skill, effort, and responsibility required by positions assigned this title. This information shall not be construed as a declaration of the specific duties and responsibilities of any particular position. It is not intended to limit or modify the right of any supervisor to assign, direct, and control the work of direct reports. The functions described are not to be interpreted as exclusive or all-inclusive of the various functions performed.

    MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination
    The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual’s race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.

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