Website Texas Tech University
Center for BioTechnology Genomics
Contributes to the university’s mission through teaching, research and service, some variation by academic unit.
The Center for Biotechnology and Genomics (CBG), a multidisciplinary center at Texas Tech University (TTU), seeks a non-tenure-track faculty member with expertise in mass spectrometry to join the Mass Spectrometry core facility at in the CBG. We are seeking outstanding candidates with expertise in mass spectrometry and protein and/or small molecule analysis (Metabolomics and Lipidomics) who will help us enhance the University’s research priorities in these crosscutting arenas.
Responsibilities include providing appropriate professional and institutional service to the University and the community, conducting and supervising original cross-disciplinary research with other departments at TTU or TTUHSC, and mentoring graduate students. The candidate is also expected to teach a graduate course in mass spectrometry, which is part of the MS in Biotechnology degree program and is also of interest to students from other departments across campus. The new faculty hire will manage the Mass Spectrometry core and must be a team player with the ability to contribute and work effectively with colleagues and multidisciplinary project teams.
Key responsibilities include:
- Management of the entire lab, which includes oversight of projects, maintaining workflow to and from the core, and offering trainings.
- Initiating and establishing collaborative research projects with faculty members at TTU, TTUHSC, and externally.
- Serving as subject-matter expert in mass spectrometry (MS) techniques (both MALDI and ESI), technologies, and data collection/analysis methodologies, as well as proteomic data analysis using a variety of bioinformatics tools and analysis of protein post-translational modifications.
- Designing and executing workflows for analytical methods for bottom-up proteomics, analyzing peptides/small molecules/drugs/metabolites using various LC techniques, and performing further qualitative/quantitative mass spectrometric analysis (PRM/SRM/MRM assay development).
- Quantitative analysis of proteomes in a mixture using labeling techniques (TMT, iTRAQ) or label-free (Spectral count, XIC).
- Analyzing data with bioinformatics tools such as Proteome Discoverer, MaxQuant, Scaffold, Ingenuity Pathway Analysis (IPA), Compound Discoverer, LipidSearch, MetaboAnalyst, XCMS, etc.
- Developing and validating automated methods for the analysis of various biomolecules to continuously improve research quality and accuracy.
- Evaluating, acquiring, maintaining, and troubleshooting a wide range of instruments and equipment including HPLC systems and mass spectrometers (Q-Exactive HF, LTQ-Orbitrap Velos, LTQ-XL, MALDI-TOF/TOF 4800); managing relations with lab technology vendors.
- Creating and implementing standard operating procedures (SOP) for lab usage and safety, and managing the lab’s chemical inventory and MSDS sheets.
- Planning, developing, and managing numerous proteomic/metabolomic research projects, serving as PI or collaborator, defining research protocols, collecting and interpreting results, and authoring publications for peer-reviewed journals.
- Assist in writing scientific publications and grants. Review literature to stay current with related technology.
- Assist in the training of new laboratory personnel, students, and collaborators.
- Extracting proteins/small molecules/lipids/metabolites from various sample sources (e.g., serum, plasma, exosome, tissues [brain, liver, placenta], cell lines, fungi, bacteria plants).
- Global profiling of metabolites/lipids from different samples sources.
Texas Tech University
Ph.D in Biology, Biotechnology, Chemistry, or related areas. Demonstrated record of effectiveness as a teacher, a record of peer reviewed publication and/or peer-reviewed creative activity which has contributed to the discipline or field of study, to the candidate’s intellectual and artistic development, and to the quality of the academic enterprise; a record of professional service appropriate to the discipline; promise of growth in teaching and research or artistic and creative activity.
Candidates should have strong training in mass spectrometry techniques applied to the analysis of peptides, proteins, and/or small molecules. Candidates should be highly motivated and enthusiastic about learning new technologies, and possess good problem-solving and organizational skills. Demonstrated leadership abilities and an ongoing commitment to serving diverse student populations, with excellent written and verbal communication skills and the ability to work with others in a collegial and multidisciplinary team atmosphere are expected. Additional qualifications include a good understanding of general biochemistry and molecular biology concepts, and excellent proficiency with Microsoft Word, Excel, and PowerPoint.
- Additional experience with MALDI-TOF and GCMS is desirable.
- Strong background in peptide/protein and/or small molecule separation techniques like UPLC/HPLC.
- SDS-PAGE and 2D-gel for protein separation.
- Knowledge of bioinformatics database search software (e.g. ProteomeDiscoverer, MASCOT, MaxQuant, LipidSearch, etc.).
- Expertise in analysis of post-translational modifications using MS.
- Familiarity with protein quantification using tagging techniques (e.g. iTRAQ, TMT) or label free quantitation (spectral count, XIC).
- Untargeted analysis of metabolites/lipids as well targeted analysis (assay development, PRM, and MRM).
- Experience working with diverse student populations and first-generation students is highly desirable.
Adherence to robust safety practices and compliance with all applicable health and safety regulations are responsibilities of all TTU employees.
Does this position work in a research laboratory?
Special Instructions to Applicants
Candidates should send their letter of interest/application, curriculum vita, copy of transcripts (official transcripts will be required upon appointment), and the contact information (name, address, telephone number, and email address) of three references.
Cover Letter, Professional/Personal References, Resume / CV, Transcript
Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as, the institutional pay plan. For additional information, please reference the institutional pay plan on the Human Resources webpage.
Travel Required: Up to 25%
Grant Funded? No
Job Group: Research Faculty
As an Equal Employment Opportunity/Affirmative Action employer, Texas Tech University is dedicated to the goal of building a culturally diverse faculty committed to teaching and working in a multicultural environment. We actively encourage applications from all those who can contribute, through their research, teaching, and/or service, to the diversity and excellence of the academic community at Texas Tech University. The university welcomes applications from minoritized candidates, women, protected veterans, persons with disabilities, and dual-career couples.
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