Bioinformatics Scientist

    Bioinformatics Scientist

    Website GAP Solutions, Inc.

    Job Title: Bioinformatics Scientist

    Location: Rockville, MD 20852 US (Primary)

    Job Type: Regular, Full-Time

    Category: Public Health

    Education: Master’s Degree Preferred

    Travel: None

    Date Posted: 11 May 2022

    Job Description:

    Position Objective: Provide services as a Bioinformatics Scientist in support of the overall functions of National Cancer Institute (NCI) within the National Institutes of Health (NIH). This position will independently provide support services to satisfy the overall operational objectives of the NCI/DCEG.

    Duties and Responsibilities:

    • Coordinate and analyze large-scale genomic and genetic data in cancer studies. This includes but are not limited to data manipulation, algorithmic implementation, bioinformatics pipeline developing, statistical programming, and integrated genomic analyses. 1
    • Generate and optimize programs and scripts for the analysis of data; create programs and algorithms and develop computational infrastructure resources for organizing and parsing data from large and complex data.
    • Serve as bioinformatics expert and coordinate with teams of biologists to conduct experimental queries and/or perform portions of studies using complex procedures and techniques common to modern bioinformatics.
    • Coordinate building bioinformatics infrastructure to ensure easy and meaningful scientific analysis and interpretation of data.
    • Provide broad-based programming and analytic support for a wide variety of bioinformatic and research projects.
    • Perform computational analysis of, and interpret results. Provide reports based on analysis of scientific data.
    • Provide interpretive analyses of data derived from different experimental platforms to generate biological meaning.
    • Collaborate with scientists to design, analyze, manage and interpret all types of data.
    • Attend scientific and programming meetings; take and compile comprehensive notes; organize and edit content of meeting reports.
    • Provide support and expertise in the Unix operating system, high performance computer clusters, programming languages (including R, Python, Perl, Python, Java, and C/C++), data visualization (e.g., ggplot2, plotly), container management, (Docker, Singularity) and computation cloud environment (DNA Nexus, Seven Bridges, Terra). 2
    • Install, troubleshoot and run open-source and commercial scientific software on the Unix and Linux platforms. 3
    • Create novel programs and algorithms that facilitate discovery of knowledge in investigating large and complex data. Participate in the design of new protocols involving computational methods.
    • Work with staff on the development and maintenance of bioinformatics tools, scripts and pipe-lines for data.
    • Participate in research design with investigators for determining best practices pertaining to the bioinformatics analysis in new and ongoing projects.
    • Collaborate with staff to review current and historical procedures for the acquisition, quality control and management of data.
    • Analyze and evaluate data cleaning and harmonization needs in the using a variety of descriptive statistics and analytic methods.
    • Instruct staff in computational analysis of data.
    • Collaborate with group members in experiments associated with data collection.
    • Interact with all levels of staff and communicate with outside collaborators in the US and abroad.
    • Work products and documents related to managing and analyzing large genomic databases in epidemiological studies.
    • Work products and documents related to providing support and expertise in the Linux operating system, HPC clusters and programming languages; provide support and expertise with the public bioinformatics and genomic databases and tools.
    • Work products and documents related to developing robust pipelines with integrating publicly available data into the downstream analysis of NHGRI/DIR-generated research data; develop computational pipelines for processing and analysis of a variety of next-generation sequencing data.
    • Work products and documents related to implementing Web-based portals for the dissemination and visualization of research data, including the application of visualization programs intended to facilitate the display of large-scale genomic data.
    • Implement Web-based portals for the dissemination and visualization of research data, including the application of visualization programs intended to facilitate the display of large-scale sequencing data within platforms such as IGV, JBrowse, the Exome Aggregation Consortium (ExAC) browser and gnomAD browser.
    • Develop computational pipelines for processing and analysis of a variety of next- generation sequencing data.
    • Provide training to scientific staff on bioinformatics techniques used in data analysis.
    • Coordinate and analyze large genomic databases in epidemiological studies. This includes but are not limited to data manipulation, algorithmic implementation, statistical programming, and integrated genomic analyses. 4
    • Provide support and expertise in the Unix operating system, databases (including Oracle) and programming languages (including Perl, Python, BioPerl, Java, XML, SQL, JavaScript, JavaServer Page, C/C++, servlets and R), object-oriented programming and design, visualization and dissemination of genetic and genomic data. 5
    • Install, troubleshoot and run open-source and commercial scientific software on the Unix and Linux platforms.
    • Provide support and expertise with the public bioinformatics and genomic databases and tools (such as GATK, SAMtools, BCFtools, PLINK, cBioPortal, gnomAD, GTEx, GDC).
    • Develop robust pipelines to integrate publicly available data into the downstream analysis of NHGRI/DIR-generated research data.
    • Work products and documents related to coordinating and analyzing large genomic databases in epidemiological studies. Ad-Hoc
    • Work products and documents related to providing support and expertise in the Unix operating system, databases (including Oracle) and programming languages; provide support and expertise with the public bioinformatics and genomic databases and tools. Ad-Hoc
    • Work products and documents related to developing robust pipelines to integrate publicly available data into the downstream analysis of NHGRI/DIR-generated research data; develop computational pipelines for processing and analysis of a variety of next- generation sequencing data. Ad-Hoc
    • Work products and documents related to implementing Web-based portals for the dissemination and visualization of research data, including the application of visualization programs intended to facilitate the display of large-scale sequencing data. Ad-Hoc

    Basic Qualifications:

    • Master’s degree in Miscellaneous Biology or a related discipline; three (3) years of specialized experience plus a Bachelor’s degree is equivalent to a Master’s degree.
    • Minimum of five (5) years of progressively responsible scientific and/or complex system management/bioinformatics experience.
    • Experience with MS Office Suite, Python, and MATLAB.
    • Experience with data mining and visualization for large-scale next-generation sequencing data (such as WGS data).

    Minimum Qualifications:

    • Strong verbal and written communication skills.
    • Excellent analytical, organizational and time management skills.
    • Ability to communicate effectively, orally and in writing, with non-technical and technical staff.
    • Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects.

    *This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

    To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

    GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job, email us at recruiting@gapsi.com. You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.

    To apply for this job please visit gapsi.mua.hrdepartment.com.