Website Washington University

    Profile: Bioinformatician
    Company: Washington University
    Posted on: 08-04-22
    Deadline: 01-10-22


    The Maher laboratory ( at Washington University integrates computational and experimental techniques to study cancer. Our diverse and interdisciplinary team enables us to focus on translating genome based discoveries into the clinic. We are recruiting a bioinformatician to focus on developing and applying computational methods for analyzing large-scale cancer genomics data collections from patients to improve our understanding of metastatic colon cancer progression (Science Advances: PMID 32577507; Nature Communications: PMID 32358485; Annals of Oncology: PMID 28950321) and metastatic castration resistant prostate cancer (Cell: PMID 30033370; JCO Precision Oncology: PMID 32903952). Active projects address topics such as noncoding regulatory mutations, cancer evolution in metastasis and treatment resistance, discovery and characterization of novel long non-coding RNAs, and the development of new bioinformatics tools.

    Principal duties and responsibilities:

    – Evaluation and design of experimental plans for sequencing-based projects studying the genetic basis of cancer.
    – Implementation and development of automated pipelines to analyze high throughput sequencing data (single cell RNA-Seq, whole genome sequencing, ATAC-Seq, etc).
    – Integration of genetic and epigenetic changes in cancer including mutations, gene expression data, epigenetic modification, copy number and structural variation.
    – Integrated pathway and gene network analysis related to cancer.
    – Analyze and interpret results to communicate with others and produce scientific publications is required.

    Preferred qualifications:

    – Applicants should have a degree in biology, bioinformatics, computational biology, or related field with a solid background in programming and statistics.

    – Candidates should be comfortable working on UNIX/Linux operating system, program with Perl and/or Python, and familiar with statistical analysis packages (SAS, R, or Bioconductor). Also expected to be familiar with bioinformatics tools and genomics databases.

    – Previous experience in cancer genomics would be an advantage but is not essential.

    Review of applications will begin immediately and will continue until the position is filled. Please send a CV and a list of three references, to Dr. Christopher Maher (

    Visit CBIRT for more opportunities.

    To apply for this job email your details to