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Generative Models for Peptide Design: Discovering Calcineurin Protein-protein Interactions Disruptors
All organisms depend on protein-protein interactions (PPIs) for cellular and biological activities. This paper introduces a novel method for building peptide binders for "undruggable"...
Discovering the Origin of Antibiotic Resistance through DNA Replication Protein Structure Analysis
Scientists from Barcelona have discovered a new hexameric protein structure for the RepB protein, which is involved in catalyzing replication initiation in Streptococcal plasmid...
The Future of Rare Disease Prediction: Machine Learning Takes the Lead
The POPDx model does not require extensive patient datasets, which makes it potentially useful for patients with rare diseases.
The POPDx framework was created to...
AGORA2: The Key to Personalized Medicine through Genome-wide Metabolic Reconstruction of Human Microbes
The digestive system is home to trillions of bacteria, which are very different in each person based on their gender, age, race, lifestyle, and...
In-depth Mapping of Protein Localizations in Whole Tissue Using Micro-scaffold Assisted Spatial Proteomics (MASP)
Researchers from the Jun Qu lab at SUNY Buffalo, New York, have developed a revolutionary method for in-depth mapping of protein localization in whole...